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Original Research

Open Access

NGAL in trans-catheter aortic valve implantation on and off RenalGuard

  • Sapir Sadon1
  • Yaron Arbel1
  • Ariel Banai1
  • Keren-Lee Rozenfeld1
  • Phillipe Taieb1
  • Aviram Hochstadt1
  • Yacov Shacham1
  • Shmuel Banai1
  • Ariel Finkelstein1
  • Ilan Merdler1

1Department of Cardiology, Tel Aviv Sourasky Medical Center, Israel. Affiliated to Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

DOI: 10.22514/sv.2021.048 Vol.17,Issue 4,July 2021 pp.55-59

Submitted: 05 January 2021 Accepted: 22 January 2021

Published: 08 July 2021

*Corresponding Author(s): Yaron Arbel E-mail:


Introduction: Acute kidney injury (AKI) is a well-known complication post invasive cardiac procedures. RenalGuard system has been shown to reduce the risk of AKI in high-risk patients by evacuating iodine-based contrast material rapidly. Neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein stored in granules of mature neutrophils and is released to the blood stream due to acute tubular damage. This report examined the biomarker as a sub study of the randomized sham control study REDUCE-AKI in the setting of Trans-Aortic Valve Implantation (TAVI).

Methods: Venous blood was drawn from 27 patients. Blood was drawn at designated time intervals: before the procedure, after 12 hours and after 24 hours. Patients were randomly allocated to active versus sham RenalGuard activity.

Results: There was no difference between baseline and 24 hours levels in NGAL values (ng/mL) in the sham group (median 70.3 IQ 21.5, 176.6) versus the active group (median 46.9, IQR 1.3, 127.7) (P = 0.259). There was also no association between NGAL and clinical complications.

Conclusion: Forced diuresis with matched hydration does not prevent AKI in patients undergoing TAVI and measuring NGAL correlates with these findings.



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Sapir Sadon,Yaron Arbel,Ariel Banai,Keren-Lee Rozenfeld,Phillipe Taieb,Aviram Hochstadt,Yacov Shacham,Shmuel Banai,Ariel Finkelstein,Ilan Merdler. NGAL in trans-catheter aortic valve implantation on and off RenalGuard. Signa Vitae. 2021. 17(4);55-59.


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