On the potential effect of circadian rhythms of cardiac troponins on the diagnosis of acute myocardial infarction
1Department of Cardiology and Cardiovascular Surgery, Samara State Medical University, Chapaevskaya Str. 89, 443099 Samara, Russia
DOI: 10.22514/sv.2021.050 Vol.17,Issue 3,May 2021 pp.79-84
Submitted: 01 February 2021 Accepted: 23 February 2021
Published: 08 May 2021
*Corresponding Author(s): Aleksey Michailovich Chaulin E-mail: firstname.lastname@example.org
Methods for the determination of cardiac troponins have been significantly improved, facilitating further advancement of the therapeutic and diagnostic process of the cardiovascular diseases case management. In particular, acceleration of the acute myocardial infarction testing (early diagnostic algorithms: 0-1 h, 0-3 h) enabled earlier detection and choice of the optimal treatment tactics. At the same time, with the increased sensitivity in the laboratory test results interpretation, there emerged a necessity to take into account some additional factors that may affect the concentration of cardiac troponins in blood serum. Several recent studies have reported the existence of circadian rhythms in cardiac troponins. This article aims to discuss the possible mechanisms of how circadian rhythms of cardiac troponins develop and their influence on the diagnosis of acute myocardial infarction.
Cardiac troponins; Cardiovascular diseases; Acute myocardial infarction; Circadian rhythms; High-sensitive analyses
Aleksey Michailovich Chaulin,Dmitry V. Duplyakov. On the potential effect of circadian rhythms of cardiac troponins on the diagnosis of acute myocardial infarction. Signa Vitae. 2021. 17(3);79-84.
 Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, et al. Fourth universal definition of myocardial infarction (2018). European Heart Journal. 2018; 40: 237-269.
 Roffi M, Patrono C, Collet J, Mueller C, Valgimigli M, Andreotti F, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: task force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). European Heart Journal. 2016; 37: 267-315.
 Myocardial infarction redefined-A consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction. European Heart Journal. 2000; 21: 1502-1513.
 Garcia-Osuna A, Gaze D, Grau-Agramunt M, Morris T, Telha C, Bartolome A, et al. Ultrasensitive quantification of cardiac troponin I by a Single Molecule Counting method: analytical validation and biological features. Clinica Chimica Acta. 2018; 486: 224-231.
 Pervan P, Svaguša T, Prkacin I, Savuk A, Bakos M, Perkov S. Urine high sensitive Troponin I measuring in patients with hypertension. Signa Vitae. 2017; 62-64.
 Chaulin AM, Karslyan LS, Grigorieva EV, Nurbaltaeva DA, Duplyakov DV. Clinical and diagnostic value of cardiac markers in human biological fluids. Kardiologiia. 2019; 59: 66-75. (In Russian)
 Mirzaii-Dizgah I, Riahi E. Salivary high-sensitivity cardiac troponin T levels in patients with acute myocardial infarction. Oral Diseases. 2013; 19: 180-184.
 Chaulin AM, Duplyakova PD, Bikbaeva GR, Tukhbatova AA, Grigorieva EV, Duplyakov DV. Concentration of high-sensitivity cardiac troponin I in the oral fluid in patients with acute myocardial infarction: a pilot study. Russian Journal of Cardiology. 2020; 25: 3814. (In Russian)
 Chaulin AM, Duplyakov DV. Increased cardiac troponins, not associated with acute coronary syndrome. Part 1. Kardiologiya: novosti, mneniya, obuchenie [Cardiology: News, Opinions, Training]. 2019; 7: 13-23. (In Russian)
 Chaulin AM, Duplyakov DV. Increased cardiac troponins, not associated with acute coronary syndrome. Part 2. Kardiologiya: novosti, mneniya, obuchenie [Cardiology: News, Opinions, Training]. 2019; 7: 24-35. (In Russian)
 Chaulin AM, Duplyakov DV. Increased natriuretic peptides not associated with heart failure. Russian Journal of Cardiology. 2020; 25: 4140. (In Russian)
 Chaulin AM, Abashina OE, Duplyakov DV. Pathophysiological mech-anisms of cardiotoxicity in chemotherapeutic agents. Russian Open Medical Journal 2020; 9: e0305.
 Lazzarino AI, Hamer M, Gaze D, Collinson P, Steptoe A. The association between cortisol response to mental stress and high-sensitivity cardiac troponin T plasma concentration in healthy adults. Journal of the American College of Cardiology. 2013; 62: 1694-1701.
 Richardson AJ, Leckie T, Watkins ER, Fitzpatrick D, Galloway R, Grimaldi R, et al. Post marathon cardiac troponin T is associated with relative exercise intensity. Journal of Science and Medicine in Sport. 2018; 21: 880-884.
 Anand A, Shah ASV, Beshiri A, Jaffe AS, Mills NL. Global adoption of high-sensitivity cardiac troponins and the universal definition of myocardial infarction. Clinical Chemistry. 2019; 65: 484-489.
 Clerico A, Padoan A, Zaninotto M, Passino C, Plebani M. Clinical relevance of biological variation of cardiac troponins. Clinical Chemistry and Laboratory Medicine. 2020. (in press)
 Sigurdardottir FD, Lyngbakken MN, Holmen OL, Dalen H, Hveem K, Røsjø H, et al. Relative prognostic value of cardiac troponin I and c-reactive protein in the general population (from the nord-trøndelag health [HUNT] study). American Journal of Cardiology. 2018; 121: 949-955.
 Mazzoccoli G, Carughi S, Sperandeo M, Pazienza V, Giuliani F, Tarquini R. Neuro-endocrine correlations of hypothalamic-pituitary-thyroid axis in healthy humans. Journal of Biological Regulators and Homeostatic Agents. 2011; 25: 249-257.
 Tsareva YO, Mayskova EA, Fedotov EA, Shvarts YG. Circadian rhythms of thyroid hormones in patients with ischemic heart disease, arterial hypertension, and atrial fibrillation. Kardiologiia. 2019; 59: 23-29.
 Wu AHB, Lu QA, Todd J, Moecks J, Wians F. Short- and long-term biological variation in cardiac troponin I measured with a high-sensitivity assay: implications for clinical practice. Clinical Chemistry. 2009; 55: 52-58.
 Aakre KM, Røraas T, Petersen PH, Svarstad E, Sellevoll H, Skadberg, et al. Weekly and 90-minute biological variations in cardiac troponin T and cardiac troponin I in hemodialysis patients and healthy controls. Clinical Chemistry. 2014; 60: 838-847.
 Klinkenberg LJJ, van Dijk J, Tan FES, van Loon LJC, van Dieijen-Visser MP, Meex SJR. Circulating cardiac troponin T exhibits a diurnal rhythm. Journal of the American College of Cardiology. 2014; 63: 1788-1795.
 Gutenbrunner C. Circadian variations of the serum creatine kinase level-a masking effect? Chronobiology International. 2000; 17: 583-590.
 Klinkenberg LJJ, Wildi K, van der Linden N, Kouw IWK, Niens M, Twerenbold R, et al. Diurnal rhythm of cardiac troponin: consequences for the diagnosis of acute myocardial infarction. Clinical Chemistry. 2016; 62: 1602-1611.
 van der Linden N, Cornelis T, Klinkenberg LJJ, Kimenai DM, Hilderink JM, Litjens EJR, et al. Strong diurnal rhythm of troponin T, but not troponin I, in a patient with renal dysfunction. International Journal of Cardiology. 2016; 221: 287-288.
 Nelson W, Tong YL, Lee JK, Halberg F. Methods for cosinor-rhythmometry. Chronobiologia. 1979; 6: 305-323.
 Dubin RF, Li Y, He J, Jaar BG, Kallem R, Lash JP, et al. Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC). BMC Nephrology. 2013; 14: 229.
 Reichlin T, Schindler C, Drexler B, Twerenbold R, Reiter M, Zellweger C, et al. One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. Archives of Internal Medicine. 2012; 172: 1211-1218.
 Rubini Gimenez M, Twerenbold R, Jaeger C, Schindler C, Puelacher C, Wildi K, et al. One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I. American Journal of Medicine. 2015; 128: 861-870.
 Wildi K, Singeisen H, Twerenbold R, Badertscher P, Wussler D, Klinkenberg LJJ, et al. Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction. International Journal of Cardiology. 2018; 270: 14-20.
 Interventional Federation of Clinical Chemistry and Laboratory Medicine. High-Sensitivity* Cardiac Troponin I and T Assay Analytical Characteristics Designated by Manufacturer IFCC Committee on Clinical Applications of Cardiac Bio-Markers (C-CB). 2020. Available at: https://www.ifcc.org/media/478231/high-sensitivity-cardiac-troponin-i-and-t-assay-analytical-characteristics-designated-by-manufacturer-v122019.pdf (Accessed: 10 February 2021).
 Aschoff J. Circadian rhythms in man. Science. 1965; 148: 1427-1432.
 Doskin VA, Lavrent’eva NA. Circadian rhythms and their role in human physiology and pathology. Sovetskaia Meditsina. 1972; 35: 67-70. (In Russian)
 Sato M, Matsuo T, Atmore H, Akashi M. Possible contribution of chronobiology to cardiovascular health. Frontiers in Physiology. 2014; 4: 409.
 Panza JA, Epstein SE, Quyyumi AA. Circadian variation in vascular tone and its relation to α-sympathetic vasoconstrictor activity. New England Journal of Medicine. 1991; 325: 986-990.
 Tofler GH, Brezinski D, Schafer AI, Czeisler CA, Rutherford JD, Willich SN, et al. Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death. New England Journal of Medicine. 1987; 316: 1514-1518.
 Fearnley GR, Balmforth G, Fearnley E. Evidence of a diurnal fibrinolytic rhythm; with a simple method of measuring natural fibrinolysis. Clinical Science. 1957; 16: 645-650.
 Suárez-Barrientos A, López-Romero P, Vivas D, Castro-Ferreira F, Núñez-Gil I, Franco E, et al. Circadian variations of infarct size in acute myocardial infarction. Heart. 2011; 97: 970-976.
 Arroyo Úcar E, Dominguez-Rodriguez A, Abreu-Gonzalez P. Influence of diurnal variation in the size of acute myocardial infarction. Medicina Intensiva. 2012; 36: 11-14. (In Russian)
 Seneviratna A, Lim GH, Devi A, Carvalho LP, Chua T, Koh T, et al. Circadian dependence of infarct size and acute heart failure in ST elevation myocardial infarction. PLoS ONE. 2015; 10: e0128526.
 Thornton SN. Overnight dehydration increases the risk of a morning infarct. Heart. 2011; 97: 1359.
 Manfredini R, Boari B, Bressan S, Gallerani M, Salmi R, Portaluppi F, et al. Influence of circadian rhythm on mortality after myocardial infarction: data from a prospective cohort of emergency calls. American Journal of Emergency Medicine. 2004; 22: 555-559.
 Ben Yedder N, Roux JF, Paredes FA. Troponin elevation in supraventric-ular tachycardia: primary dependence on heart rate. Canadian Journal of Cardiology. 2011; 27: 105-109.
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