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To everything there is a season: COVID-19 vaccination and thrombosis

  • Giovanni Landoni1,2
  • Pasquale Nardelli1
  • Alberto Zangrillo1,2

1Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

2Vita-Salute San Raffaele University, 20132 Milan, Italy

DOI: 10.22514/sv.2021.075 Vol.17,Issue 3,May 2021 pp.1-2

Submitted: 22 April 2021 Accepted: 07 May 2021

Published: 08 May 2021

*Corresponding Author(s): Giovanni Landoni E-mail:

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Giovanni Landoni,Pasquale Nardelli,Alberto Zangrillo. To everything there is a season: COVID-19 vaccination and thrombosis. Signa Vitae. 2021. 17(3);1-2.


[1] European Medicines Agency. Vaxzervia summary of product characteristics. 2021. Available at: https://www.ema.europa. eu/en/documents/product-information/vaxzevria-previously-covid-19-vaccine-astrazeneca-epar-product-information_en.pdf (Accessed: 07 May 2021).

[2] European Medicines Agency. COVID-19 vaccine safety update – VAXZEVRIA, 14 April 2021. 2021. Available at: (Accessed: 07 May 2021)

[3] Skajaa N, Horváth-Puhó E, Adelborg K, Prandoni P, Rothman KJ, Sørensen HT. Venous thromboembolism in Denmark: seasonality in occurrence and mortality. TH Open. 2019; 3: e171–e179.

[4] Ferro JM, Lopes GC, Rosas MJ, Araújo C, Henriques I, Venoport Investigators. Chronobiology of cerebral vein and dural sinus thrombosis. Cerebrovascular Diseases. 2002; 14: 265.

[5] Vannini L, Llanos Gómez JM, Quijada-Fumero A, Fernández Pérez AB, Hernández Afonso JS. COVID-19 quarantine and acute pulmonary embolism. Revista Española de Cardiología. 2020; 73: 680–682.

[6] Franch-Llasat D, Mayor-Vázquez E, Pedregosa-Díaz J, Herrero-Redondo M, Ortin-Font X, Roche-Campo F. e-Thrombosis in the COVID-19 era: collateral effects of confinement. Medicina Intensiva. 2021; 45: 122–124.

[7] Koudouovoh-Tripp P, Hüfner K, Egeter J, Kandler C, Giesinger JM, Sopper S, et al. Stress enhances proinflammatory platelet activity: the impact of acute and chronic mental stress. Journal of Neuroimmune Pharmacology. 2021; 16: 500–512.

[8] Sandrini L, Ieraci A, Amadio P, Zarà M, Barbieri SS. Impact of acute and chronic stress on thrombosis in healthy individuals and cardiovascular disease patients. International Journal of Molecular Sciences. 2020; 21: 7818.

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