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Innovations, advances, and updates in neurosurgery

  • Po-Cheng Lo1
  • Woon-Man Kung2

1Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 23142 New Taipei City, Taiwan

2Division of Neurosurgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 23142 New Taipei City, Taiwan

DOI: 10.22514/sv.2021.122 Vol.18,Issue 2,March 2022 pp.1-7

Submitted: 02 May 2021 Accepted: 22 June 2021

Published: 08 March 2022

*Corresponding Author(s): Woon-Man Kung E-mail:


Neuroscience plays an important role in the basic study to control the coordination of the human body, thinking, and behavioral patterns that keeps pace with time. It is a complex and multidisciplinary scientific body of knowledge related to the nervous system. There are different and overlapping aspects in this field, which are closely interconnected to several elementary professional subjects such as science, technology, engineering, and mathematics. The number of aging population is expected to rise abruptly in the future, such that more than one in six adults globally will be 65 years or older by the year 2050. Advancing age of the elderly would obviously correlate to a rise in the burden of neurological diseases. Neurosurgery comprises surgical interventions involved in the management of central and peripheral nervous system diseases. Rapid technical and technological advances in the neurosurgical field in the past decades have revolutionized better outcomes and prognoses for patients. The present paper discusses selected relevant innovations, advances, and updates in neurosurgery. Further theragnostic strategies and perspectives to treat victims with neurological deficits are also summarized. We hereby outline some noteworthy, major, plus recent innovations, advances, and updates in the field of neurosurgery.


Neurosurgery; Innovations; Advances; Updates; History; Technology

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Po-Cheng Lo,Woon-Man Kung. Innovations, advances, and updates in neurosurgery. Signa Vitae. 2022. 18(2);1-7.


[1] Doyle NM, Doyle JF, Walter EJ. The life and work of Harvey Cushing 1869-1939: a pioneer of neurosurgery. Journal of the Intensive Care Society. 2017; 18: 157–158.

[2] Burke RE. Sir Charles Sherrington’s the integrative action of the nervous system: a centenary appreciation. Brain. 2007; 130: 887–894.

[3] Blitz AM, Ahmed AK, Rigamonti D. Founder of modern hydrocephalus diagnosis and therapy: Walter Dandy at the Johns Hopkins Hospital. Journal of Neurosurgery. 2019; 131: 1046–1051.

[4] Izuo M. Medical history: Seishu Hanaoka and his success in breast cancer surgery under general anesthesia two hundred years ago. Breast Cancer. 2004; 11: 319–324.

[5] Jianhua X, Zhenying H, Bingbing L, Jian S, Shengping Y, Ye T, et al. Comparison of Surgical Outcomes and Recovery of Neurologic and Linguistic Functions in the Dominant Hemisphere After Basal Ganglia Hematoma Evacuation by Craniotomy versus Endoscopy. World Neurosurgery. 2019; 129: e494–e501.

[6] Yadav RI, Long L, Yanming C. Comparison of the effectiveness and outcome of microendoscopic and open discectomy in patients suffering from lumbar disc herniation. Medicine. 2019; 98: e16627.

[7] Stefan P, Pfandler M, Lazarovici M, Weigl M, Navab N, Euler E, et al. Three-dimensional-Printed Computed Tomography-Based Bone Models for Spine Surgery Simulation. Simulation in Healthcare. 2020; 15: 61–66.

[8] Nadel J, McNally JS, DiGiorgio A, Grandhi R. Emerging Utility of Applied Magnetic Resonance Imaging in the Management of Traumatic Brain Injury. Medical Sciences. 2021; 9: 10.

[9] Sarikaya I, Kamel WA, Ateyah KK, Essa NB, AlTailji S, Sarikaya A. Visual versus semiquantitative analysis of (18)F- fluorodeoxyglucose-positron emission tomography brain images in patients with dementia. World Journal of Nuclear Medicine. 2021; 20: 82–89.

[10] Aghakhanyan G, Saur D, Rullmann M, Weise CM, Schroeter ML, Marek K, et al. PET/MRI Delivers Multimodal Brain Signature in Alzheimer’s Disease with De Novo PSEN1 Mutation. Current Alzheimer Research. 2021; 18: 178–184.

[11] Vay SU, Werner J, Kabbasch C, Schmidt M, Drzezga A, Fink GR, et al. Uncovering an Optic Nerve Sheath Meningioma Using 68Ga-DOTATATE PET/CT. Clinical Nuclear Medicine. 2021. (in press)

[12] Verburg N, de Witt Hamer PC. State-of-the-art imaging for glioma surgery. Neurosurgical Review. 2021; 44: 1331–1343.

[13] Kuroiwa T, Nonoguchi N, Wanibuchi M. Intraoperative Fluorescence Imaging of Brain Tumors. Gan To Kagaku Ryoho. 2021; 48: 186–189.(In Japanese)

[14] Mansour A, Endo T, Inoue T, Sato K, Endo H, Fujimura M, et al. Clipping of an anterior spinal artery aneurysm using an endoscopic fluorescence imaging system for craniocervical junction epidural arteriovenous fistula: technical note. Journal of Neurosurgery-Spine. 2019; 31: 279–284.

[15] Molina CA, Theodore N, Ahmed AK, Westbroek EM, Mirovsky Y, Harel R, et al. Augmented reality-assisted pedicle screw insertion: a cadaveric proof-of-concept study. Journal of Neurosurgery-Spine. 2019; 31: 139–146.

[16] Vadalà G, Salvatore SD, Ambrosio L, Russo F, Papalia R, Denaro V. Robotic Spine Surgery and Augmented Reality Systems: a State of the Art. Neurospine. 2020; 17: 88–100.

[17] Yang M. Multimodal neurocritical monitoring. Biomedical Journal. 2020; 43: 226–230.

[18] Roldán M, Abay TY, Kyriacou PA. Non-Invasive Techniques for Multimodal Monitoring in Traumatic Brain Injury: Systematic Review and Meta-Analysis. Journal of Neurotrauma. 2020; 37: 2445–2453.

[19] Okonkwo DO, Shutter LA, Moore C, Temkin NR, Puccio AM, Madden CJ, et al. Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: a Phase II Randomized Trial. Critical Care Medicine. 2017; 45: 1907–1914.

[20] Kaya I, Çakır V, Cingoz ID, Atar M, Gurkan G, Sahin MC, et al. Comparison of cerebral AVMs in patients undergoing surgical resection with and without prior endovascular embolization. International Journal of Neuroscience. 2021. (in press)

[21] Shakur SF, Brunozzi D, Alaraj A. Transarterial glue embolization and covered stenting of a large carotid body tumor in the same setting: neuroendovascular surgical video. World Neurosurgery. 2019; 124: 44.

[22] Yadav YR, Parihar V, Pande S, Namdev H, Agarwal M. Endoscopic third ventriculostomy. Journal of Neurosciences in Rural Practice. 2012; 3: 163–173.

[23] Vasudevan K, Saad H, Oyesiku NM. The Role of Three-Dimensional Endoscopy in Pituitary Adenoma Surgery. Neurosurgery Clinics of North America. 2019; 30: 421–432.

[24] Ahn Y. Endoscopic spine discectomy: indications and outcomes. International Orthopaedics. 2019; 43: 909–916.

[25] Virk S, Qureshi S. Navigation in minimally invasive spine surgery. Journal of Spine Surgery. 2019; 5: S25–S30.

[26] Shweikeh F, Amadio JP, Arnell M, Barnard ZR, Kim TT, Johnson JP, et al. Robotics and the spine: a review of current and ongoing applications. Neurosurgical Focus. 2014; 36: E10.

[27] Lozano AM, Lipsman N, Bergman H, Brown P, Chabardes S, Chang JW, et al. Deep brain stimulation: current challenges and future directions. Nature Reviews Neurology. 2019; 15: 148–160.

[28] Rivera M, Norman S, Sehgal R, Juthani R. Updates on Surgical Management and Advances for Brain Tumors. Current Oncology Reports. 2021; 23: 35.

[29] Wolpaw JR, Millán JDR, Ramsey NF. Brain-computer interfaces: Definitions and principles. Handbook of Clinical Neurology. 2020; 168: 15–23.

[30] Krucoff MO, Rahimpour S, Slutzky MW, Edgerton VR, Turner DA. Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation. Frontiers in Neuroscience. 2016; 10: 584.

[31] Hammond SM, Aartsma-Rus A, Alves S, Borgos SE, Buijsen RAM, Collin RWJ, et al. Delivery of oligonucleotide-based therapeutics: challenges and opportunities. EMBO Molecular Medicine. 2021; 13: e13243.

[32] Kwik M, Hainzl S, Oppelt J, Tichy B, Koller U, Bernardinelli E, et al. Selective Activation of CNS and Reference PPARGC1A Promoters Is Associated with Distinct Gene Programs Relevant for Neurodegenerative Diseases. International Journal of Molecular Sciences. 2021; 22: 3296.

[33] Minakawa EN, Nagai Y. Protein Aggregation Inhibitors as Disease-Modifying Therapies for Polyglutamine Diseases. Frontiers in Neuro-science. 2021; 15: 621996.

[34] Fayazi N, Sheykhhasan M, Soleimani Asl S, Najafi R. Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment. Molecular Neurobiology. 2021. (in press)

[35] Nidetz NF, McGee MC, Tse LV, Li C, Cong L, Li Y, et al. Adeno-associated viral vector-mediated immune responses: Understanding barriers to gene delivery. Pharmacology & Therapeutics. 2020; 207: 107453.

[36] Caffery B, Lee JS, Alexander-Bryant AA. Vectors for Glioblastoma Gene Therapy: Viral & Non-Viral Delivery Strategies. Nanomaterials. 2019; 9: 105.

[37] Schroeder J, Kueper J, Leon K, Liebergall M. Stem cells for spine surgery. World Journal of Stem Cells. 2015; 7: 186–194.

[38] Liu Z, Cheung HH. Stem Cell-Based Therapies for Parkinson Disease. International Journal of Molecular Sciences. 2020; 21: 8060.

[39] Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001; 414: 105–111.

[40] Kriegeskorte N, Douglas PK. Cognitive computational neuroscience. Nature Neuroscience. 2018; 21: 1148–1160.

[41] Jayaraman V. Biophysics of the Brain: from Molecules to Networks. Biophysical Journal. 2017; 113: E1.

[42] Houser MC, Tansey MG. The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis? NPJ Parkinsons Disease. 2017; 3: 3.

[43] Kim S, Kwon SH, Kam TI, Panicker N, Karuppagounder SS, Lee S, et al. Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease. Neuron. 2019; 103: 627–641.e7.

[44] Kim DS, Choi HI, Wang Y, Luo Y, Hoffer BJ, Greig NH. A New Treatment Strategy for Parkinson’s Disease through the Gut-Brain Axis: The Glucagon-Like Peptide-1 Receptor Pathway. Cell Transplantation. 2017; 26: 1560–1571.

[45] Jing Y, Yu Y, Bai F, Wang L, Yang D, Zhang C, et al. Effect of fecal microbiota transplantation on neurological restoration in a spinal cord injury mouse model: involvement of brain-gut axis. Microbiome. 2021; 9: 59.

[46] Jogia T, Ruitenberg MJ. Traumatic Spinal Cord Injury and the Gut Microbiota: Current Insights and Future Challenges. Frontiers in Immunology. 2020; 11: 704.

[47] Ma Q, Xing C, Long W, Wang HY, Liu Q, Wang R. Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis. Journal of Neuroinflammation. 2019; 16: 53.

[48] Vázquez-Guardado A, Yang Y, Bandodkar AJ, Rogers JA. Recent advances in neurotechnologies with broad potential for neuroscience research. Nature Neuroscience. 2020; 23: 1522–1536.

[49] Altimus CM, Marlin BJ, Charalambakis NE, Colón-Rodriquez A, Glover EJ, Izbicki P, et al. The Next 50 Years of Neuroscience. Journal of Neuroscience. 2020; 40: 101–106.

[50] Schaller B. Extracranial-intracranial bypass surgery to reduce the risk of haemodynamic stroke in cerebroocclusive atherosclerotic disease of the anterior cerebral circulation - a systematic review. Neurologia i Neurochirurgia Polska. 2007; 41: 457–471.

[51] Rahal JP, Malek AM. Clip occlusion versus coil embolization for the treatment of cerebral aneurysms. Journal of Neurosurgical Sciences. 2012; 56: 175–190.

[52] Gahremanpour A, Perin EC, Silva G. Carotid artery stenting versus endarterectomy: a systematic review. Texas Heart Institute Journal. 2012; 39: 474–487.

[53] Bassett DS, Cullen KE, Eickhoff SB, Farah MJ, Goda Y, Haggard P, et al. Reflections on the past two decades of neuroscience. Nature Reviews Neuroscience. 2020; 21: 524–534.

[54] Monje M, Borniger JC, D’Silva NJ, Deneen B, Dirks PB, Fattahi F, et al. Roadmap for the Emerging Field of Cancer Neuroscience. Cell. 2020; 181: 219–222.

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