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Original Research

Open Access

Thiol disulfide homeostasis in primary dysmenorrhea

  • Atakan Savrun1
  • Şeyda Tuba Savrun1
  • Ebubekir Dirican2
  • Emre Gökçen3
  • Yeliz Kasko Arıcı4
  • Ali Aygün1
  • Vakkas Korkmaz5
  • Salim Neşelioğlu6
  • Özcan Erel6
  • Tuğba Raika Kıran7

1Department of Emergency Medicine, Ordu University Faculty of Medicine, 52100 Ordu, Turkey

2Health Services Vocational School, Bayburt University, 69010 Bayburt, Turkey

3Department of Emergency Medicine, Bozok University Faculty of Medicine, 66100 Yozgat, Turkey

4Department of Biostatistics and Medical Informatics, Ordu University Faculty of Medicine, 52100 Ordu, Turkey

5Ankara Doctor Zekai Tahir Burak Women Health Educatıon And Research Hospıtal Gynecologic Oncology Surgery, 06730 Ankara, Turkey

6Department of Medical Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University, 06760 Ankara, Turkey

7Department of Biomedical Engineering, Iskenderun Technical University, 31300 Iskenderun, Turkey

DOI: 10.22514/sv.2021.151 Vol.18,Issue 2,March 2022 pp.97-103

Submitted: 21 June 2021 Accepted: 10 August 2021

Published: 08 March 2022

*Corresponding Author(s): Atakan Savrun E-mail:


Oxidative stress is defined as a result of the loss of balance between the production of free radical or reactive oxygen species and the antioxidant system. This study aimed to determine the level of thiol-disulfide homeostasis (TDH) in the serum of women with primary dysmenorrhea. The study group consisted of 42 subjects with primary dysmenorrhea, and the control group consisted of 30 volunteer women with demographic characteristics similar to the study group. Native thiol (SH), total thiol (TSH), disulphide (SS), and SH/SS parameters were measured for TDH of the subjects. The SH (p = 0.038) and SH/TSH (p = 0.046) levels were significantly higher while SS (p = 0.013), SS/SH (p = 0.042) and SS/TSH (p = 0.046) levels were lower in the study group than in the healthy control group. The SS cut-off value was determined as 17.85 in the study group (sensitivity = 61.9%, specificity = 43.3%). Therefore, the probability of dysmenorrhea may increase significantly when SS levels fall below this value. In subjects with dysmenorrhea, there was a decrease in SS levels and an increase in SH levels in order to protect the cells and tissues from the harmful effects of free radicals.


Primary dysmenorrhea; Thiol-disulfide; Oxidative stress; ROC analysis; TDH

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Atakan Savrun,Şeyda Tuba Savrun,Ebubekir Dirican,Emre Gökçen,Yeliz Kasko Arıcı,Ali Aygün,Vakkas Korkmaz,Salim Neşelioğlu,Özcan Erel,Tuğba Raika Kıran. Thiol disulfide homeostasis in primary dysmenorrhea. Signa Vitae. 2022. 18(2);97-103.


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