Multimodal analgesia for postoperative pain in Asia: a review of evidence with clinical focus on dexketoprofen and tramadol/dexketoprofen ﬁxed-dose combination
1Department of Anesthesiology, Asian Hospital and Medical Center, 1780 Manila, Philippines
2Department of Orthopedics, Island Hospital, 10450 Penang, Malaysia
3President, Paolo Procacci Foundation (FPP), 00193 Rome, Italy
4Regional Asia Paciﬁc Menarini Medical Team, 117440 Singapore, Singapore
Submitted: 19 July 2021 Accepted: 25 August 2021
Online publish date: 26 September 2021
The majority of patients who have undergone surgery experience moderate-to-severe postoperative pain. Asian patients tend to under-report pain and are consequently under-treated. Poor postoperative pain management increases the risk of morbidity, prolonged opioid use, lower quality of life outcomes and the risk of chronic post-surgical pain. Multimodal analgesia is the cornerstone of postoperative pain management. Non-steroidal anti-inflammatory drugs are considered a core component of multimodal analgesia due to their anti-inflammatory and analgesic properties. Use of a consistent non-steroidal anti-inflammatory throughout the postoperative period can help to achieve and maintain adequate pain relief. This review investigates the use of multimodal analgesia in postoperative pain management in Asia, with a focus on clinicians’ experience with dexketoprofen as a non-steroidal anti-inflammatory therapy throughout the postoperative period and its combination as fixed dose with Tramadol, a centrally acting synthetic opioid analgesic, in Asian patients, when necessary.
Multimodal analgesia; Dexketoprofen; Tramadol; Fixed dose combination; Asia
Maria Dolma Santos,Kim Soon Oh,Giustino Varrassi,Dinesh Nagrale. Multimodal analgesia for postoperative pain in Asia: a review of evidence with clinical focus on dexketoprofen and tramadol/dexketoprofen ﬁxed-dose combination. Signa Vitae. 2021.doi:10.22514/sv.2021.210.
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