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Multimodal analgesia for postoperative pain in Asia: a review of evidence with clinical focus on dexketoprofen and tramadol/dexketoprofen fixed-dose combination

  • Maria Dolma Santos1
  • Kim Soon Oh2
  • Giustino Varrassi3
  • Dinesh Nagrale4

1Department of Anesthesiology, Asian Hospital and Medical Center, 1780 Manila, Philippines

2Department of Orthopedics, Island Hospital, 10450 Penang, Malaysia

3President, Paolo Procacci Foundation (FPP), 00193 Rome, Italy

4Regional Asia Pacific Menarini Medical Team, 117440 Singapore, Singapore

DOI: 10.22514/sv.2021.210

Submitted: 19 July 2021 Accepted: 25 August 2021

Online publish date: 26 September 2021

*Corresponding Author(s): Giustino Varrassi E-mail:


The majority of patients who have undergone surgery experience moderate-to-severe postoperative pain. Asian patients tend to under-report pain and are consequently under-treated. Poor postoperative pain management increases the risk of morbidity, prolonged opioid use, lower quality of life outcomes and the risk of chronic post-surgical pain. Multimodal analgesia is the cornerstone of postoperative pain management. Non-steroidal anti-inflammatory drugs are considered a core component of multimodal analgesia due to their anti-inflammatory and analgesic properties. Use of a consistent non-steroidal anti-inflammatory throughout the postoperative period can help to achieve and maintain adequate pain relief. This review investigates the use of multimodal analgesia in postoperative pain management in Asia, with a focus on clinicians’ experience with dexketoprofen as a non-steroidal anti-inflammatory therapy throughout the postoperative period and its combination as fixed dose with Tramadol, a centrally acting synthetic opioid analgesic, in Asian patients, when necessary.


Multimodal analgesia; Dexketoprofen; Tramadol; Fixed dose combination; Asia

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Maria Dolma Santos,Kim Soon Oh,Giustino Varrassi,Dinesh Nagrale. Multimodal analgesia for postoperative pain in Asia: a review of evidence with clinical focus on dexketoprofen and tramadol/dexketoprofen fixed-dose combination. Signa Vitae. 2021.doi:10.22514/sv.2021.210.


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