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Clinical and paraclinical characteristics of young patients with myocardial infarction from Northeast of Romania

  • Andrei-Nicolae Ceobanu1
  • Larisa Anghel2,3,*,
  • Radu Sascău2,3,*,
  • Iulian-Dan Cuciureanu1,2
  • Constantin-Bogdan Monac1
  • Alexandru-Florin Braniște4
  • Răzvan Achiței5
  • Cristian Stătescu2,3

1Neurology Department, Emergency University Hospital “Prof. Dr. N. Oblu”, 700112 Iasi, Romania

2Internal Medicine Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania

3Cardiology Department, Cardiovascular Diseases Institute “Prof. Dr. George I.M.Georgescu”, 700503 Iasi, Romania

4Endocrinology Department, Emergency University Hospital "Sf. Spiridon", 700111 Iasi, Romania

5Anaesthiology and Intensive Care department, Regional Institute of Oncology, 700483 Iasi, Romania

DOI: 10.22514/sv.2021.255 Vol.18,Issue 5,September 2022 pp.95-102

Submitted: 16 September 2021 Accepted: 16 November 2021

Published: 08 September 2022

*Corresponding Author(s): Larisa Anghel E-mail:
*Corresponding Author(s): Radu Sascău E-mail:


The aim of this study was to evaluate the clinical and paraclinical features in young patients (18–40 years) with acute myocardial infarction (AMI) in the Northeast of Romania. We have considered all patients admitted between the 1st of January 2017 through the 31st of December 2019 at a tertiary care Cardiology Institute with the primary discharge diagnosis of AMI. These patients have been split into 2 groups depending on their age: the first group consisting of patients with an age equal to or lower than 40 years old and the second group consisting of patients with an age greater than 40 years old. After this, we have randomly selected a representative sample from each of the two groups. A total of 99 patients were ultimately enrolled in the study: 42 in the first group and 57 in the second group. Data collected included age, gender, medical history, laboratory tests, echocardiography parameters, coronarography study results, and case outcome. Most young patients with myocardial infarction were male, more likely to smoke (69% vs 35.1%, p = 0.001), and with a positive family history of cardiovascular diseases (35.7% vs 1.8%, p < 0.001) in comparison to their older counterparts. Also, they had fewer comorbidities, such as diabetes mellitus, hypertension, or a positive history of stroke or atrial fibrillation. Mean ejection fraction was significantly higher in young patients (43.4 ± 10.65 vs 37.16 ± 10.77, p = 0.005) and both tricuspid and mitral valve regurgitations were less severe. Coronary lesions were more severe in the older patients (p = 0.009), usually with more coronary arteries involved. No significant difference was recorded in the number of hospitalization days or in the case outcome. Acute myocardial infarction in young patients typically occurs more in men who smoke, those who are more than 30 years old, and those who have a positive family history of cardiovascular diseases. Echocardiographic parameters seem to be better than in the case of older patients and the coronary involvement is usually less severe.


Myocardial infarction; Young adults; Cardiovascular risk factors; Mortality

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Andrei-Nicolae Ceobanu,Larisa Anghel,Radu Sascău,Iulian-Dan Cuciureanu,Constantin-Bogdan Monac,Alexandru-Florin Braniște,Răzvan Achiței,Cristian Stătescu. Clinical and paraclinical characteristics of young patients with myocardial infarction from Northeast of Romania. Signa Vitae. 2022. 18(5);95-102.


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