Hemodynamic efficacy of a motor-driven automatic device performing simultaneous sternothoracic cardiopulmonary resuscitation compared to standard cardiopulmonary resuscitation in an animal model of cardiac arrest
1Department of Emergency Medicine, Yonsei University Wonju College of Medicine, 26426 Wonju, Republic of Korea
2Department of Emergency Medicine, College of Medicine, Dankook University, 31116 Cheonan, Republic of Korea
3Center of Biomedical Data Science, Yonsei University Wonju College of Medicine, 26426 Wonju, Republic of Korea
DOI: 10.22514/sv.2022.021 Vol.19,Issue 2,March 2023 pp.66-73
Submitted: 23 December 2021 Accepted: 15 February 2022
Published: 08 March 2023
The aim of this study was to investigate hemodynamic effects and resuscitation outcomes of simultaneous sternothoracic cardiopulmonary resuscitation (SST-CPR) with a prototype of a motor-driven automatic device, comparing to manual standard CPR (S-CPR), in an animal model of ventricular fibrillation (VF). 20 male pigs were randomized to receive standard CPR (S-CPR group) or CPR with an automatic SST-CPR device (A-CPR group) after 5 minutes of VF. Five minutes of basic life support CPR was performed, followed by 10 minutes of advanced life support CPR. Hemodynamic variables including systolic blood pressure (SBP), diastolic blood pressure (DBP), coronary perfusion pressure (CPP), and end-tidal carbon dioxide tension (ETCO2), and resuscitation outcomes including rate of restoration of spontaneous circulation (ROSC) and 2-hour survival were compared between two groups. Ten animals among the A-CPR group and 8 animals among the S-CPR group were included in the final analysis. SBP was higher in the A-CPR group than in the S-CPR group during CPR (p = 0.046). The DBP, CPP and ETCO2 were not different between two groups (p = 0.412, 0.585, and 0.243, respectively). ROSC rate was 38% in the S-CPR group and 10% in the A-CPR group (p = 0.275). The 2-hour survival rate was 25% in the S-CPR group and 0% in the A-CPR group (p = 0.183). In a swine model of cardiac arrest, CPR with a prototype of a motor-driven automatic SST-CPR device, compared with standard CPR, produced higher systolic blood pressure, but there was no difference in diastolic pressure, coronary perfusion pressure, ROSC rate and 2-hour survival rate.
Cardiac arrest; Cardiopulmonary resuscitation; Life support
Kyoung-Chul Cha,Hyung Il Kim,Yoon Suk Lee,Hye Sim Kim,Woo Jin Jung,Young Il Roh,Sung Oh Hwang. Hemodynamic efficacy of a motor-driven automatic device performing simultaneous sternothoracic cardiopulmonary resuscitation compared to standard cardiopulmonary resuscitation in an animal model of cardiac arrest. Signa Vitae. 2023. 19(2);66-73.
 Chan PS, McNally B, Tang F, Kellermann A, CARES Surveillance Group. Recent trends in survival from out-of-hospital cardiac arrest in the United States. Circulation. 2014; 130: 1876–1882.
 Guidelines for cardiopulmonary resuscitation and emergency cardiac care. Emergency cardiac care committee and subcommittees, American Heart Association. Part II. Adult basic life support. Journal of the American Medical Association. 1992; 268: 2184–2198.
 International liaison committee on resuscitation. 2005 international con-sensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Part 2: adult basic life support. Resuscitation. 2005; 67: 187–201.
 Perkins GD, Travers AH, Berg RA, Castren M, Considine J, Escalante R, et al. Part 3: adult basic life support and automated external defibrillation: 2015 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation. 2015; 95: e43–69.
 Fitzgerald KR, Babbs CF, Frissora HA, Davis RW, Silver DI. Cardiac output during cardiopulmonary resuscitation at various compression rates and durations. American Journal of Physiology-Heart and Circulatory Physiology. 1981; 241: H442–H448.
 Klouche K, Weil MH, Sun S, Tang W, Povoas H, Bisera J. Stroke volumes generated by precordial compression during cardiac resuscitation. Critical Care Medicine. 2002; 30: 2626–2631.
 Wik L, Kramer-Johansen J, Myklebust H, Sørebø H, Svensson L, Fellows B, et al. Quality of cardiopulmonary resuscitation during out-of-hospital cardiac arrest. Journal of the American Medical Association. 2005; 293: 299–304.
 Abella BS Alvarado JP, Myklebust H, Edelson DP, Barry A, O’Hearn N, et al. Quality of cardiopulmonary resuscitation during in-hospital cardiac arrest. Journal of the American Medical Association. 2005; 293: 305–310.
 Talley DB, Ornato JP, Clarke AM. Computer aided characterization and optimization of the thumper compression waveform in closed-chest CPR. Biomedical Instrumentation & Technology. 1990; 24: 283–288.
 Cohen TJ, Tucker KJ, Lurie KG, Redberg RF, Dutton JP, Dwyer KA, et al. Active compression-decompression. A new method of cardiopulmonary resuscitation. Cardiopulmonary Resuscitation Working Group. Journal of the American Medical Association. 1992; 267: 2916–2923.
 Timerman S, Cardoso LF, Ramires JA, Halperin H. Improved hemo-dynamic performance with a novel chest compression device during treatment of in-hospital cardiac arrest. Resuscitation. 2004; 61: 273–280.
 Perkins GD, Lall R, Quinn T, Deakin CD, Cooke MW, Horton J, et al. Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised controlled trial. The Lancet. 2015; 385: 947–955.
 Wik L, Olsen JA, Persse D, Sterz F, Lozano M, Brouwer MA, et al. Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest. The randomized CIRC trial. Resuscitation. 2014; 85: 741–748.
 Hwang SO, Lee KH, Cho JH, Oh BJ, Gupta DS, Ornato JP, et al. Simultaneous sternothoracic cardiopulmonary resuscitation: a new method of cardiopulmonary resuscitation. Resuscitation. 2001; 48: 293–299.
 Hwang SO, Lee KH, Lee JW, Lee SY, Yoo BS, Yoon J, et al. Simultaneous sterno-thoracic cardiopulmonary resuscitation improves short-term survival rate in canine cardiac arrests. Resuscitation. 2002; 53: 209–216.
 Percie du Sert N, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, et al. Reporting animal research: explanation and elaboration for the arrive guidelines 2.0. PLoS Biology. 2020; 18: e3000411.
 Garry BP, Bivens HE. The Seldinger technique. Journal of Cardiothoracic and Vascular Anesthesia. 1988; 2: 403.
 Song KJ, Kim JB, Kim J, Kim C, Park SY, Lee CH, et al. Part 2. Adult basic life support: 2015 Korean guidelines for cardiopulmonary resuscitation. Clinical and Experimental Emergency Medicine. 2016; 3: S10–S16.
 Idris AH, Becker LB, Ornato JP, Hedges JR, Bircher NG, Chandra NC, et al. Utstein-style guidelines for uniform reporting of laboratory CPR research. A statement for healthcare professionals from a task force of the American heart association, the American college of emergency physicians, the American college of cardiology, the European resuscitation council, the heart and stroke foundation of Canada, the institute of critical care medicine, the safar center for resuscitation research, and the society for academic emergency medicine. Writing group. Circulation. 1996; 94: 2324–2336.
 Voorhees WD, Babbs C, Tacker WA. Regional blood flow during cardiopulmonary resuscitation in dogs. Critical Care Medicine. 1980; 8: 134–136.
 Steen S, Liao Q, Pierre L, Paskevicius A, Sjöberg T. Evaluation of LUCAS, a new device for automatic mechanical compression and active decompression resuscitation. Resuscitation. 2002; 55: 285–299.
 Lee DK, Cha YS, Kim OH, Cha KC, Lee KH, Hwang SO, et al. Effect of automated simultaneous sternothoracic cardiopulmonary resuscitation device on hemodynamics in out-of-hospital cardiac arrest patients. The Journal of Emergency Medicine. 2018; 55: 226–234.
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