Therapeutic agents for ARDS
1Critical Care Research Center, Parc Taulí Hospital Universitari, 08208 Sabadell, Spain
2Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain 3CIBER de Enfermedades Respiratorias (CIBERES), 28029 Madrid, Spain
Submitted: 31 December 2021 Accepted: 23 March 2022
Online publish date: 18 May 2022
In spite of supportive care of patients with acute respiratory distress syndrome (ARDS), morbidity and mortality of these patients are considerable and effective therapies centred in ARDS pathophysiology are needed. Substantial progress in pharmacological therapies has been noticed, however, several studies have not been successfully translated to the clinics. Nonetheless, many preclinical and clinical studies are ongoing. In this review, pharmacological therapies underlying ARDS pathophysiology are summarized: therapies targeting the alveolocapillary membrane, mucolytics, bronchodilators, immunomodulators, anticoagulants and fibrinolytics, aspirin, and other treatments are discussed, including both, studies with beneficial and controversial results, and ongoing trials. In addition, a section concerning preclinical studies is included. An enlarged understanding of ARDS pathophysiology and its fundamental pathways and mechanism, together with the identification of ARDS subsets of patients and phenotypes will maximise patient response to a specific treatment.
Acute respiratory distress syndrome (ARDS); Acute lung injury; COVID-19; Sepsis
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