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Individualized management objectives for hypoxic-ischemic brain injury after cardiac arrest

  • Ying Feng1
  • Xiaohua Zhang1
  • Bo Sun1
  • Minli Li1,*,

1Department of Gastroenterology, Nanjing Medical University, Jinling Hospital, 210002 Nanjing, Jiangsu, China

DOI: 10.22514/sv.2022.051 Vol.19,Issue 4,July 2023 pp.20-30

Submitted: 22 January 2022 Accepted: 07 May 2022

Published: 08 July 2023

*Corresponding Author(s): Minli Li E-mail:


Hypoxic-ischemic brain injury after cardiac arrest is the main cause of death and neurologic dysfunction in patients after the return of spontaneous circulation. The mechanisms of ischemic and hypoxic brain injury include hypoxia of brain tissue caused by the cessation of cerebral blood flow during the initial cardiac arrest and cerebrovascular dysfunction and reperfusion injury after the recovery of circulation. Cerebral circulatory perfusion, cerebral autoregulation, and cerebral edema can be monitored and controlled as therapeutic targets. In this study, from the aspects of body temperature, mean arterial pressure, oxygen concentration, partial pressure of carbon dioxide in the artery, and cerebral edema, monitoring methods such as measurement of cerebral oxygen saturation, assessment of cerebral blood flow, imaging of the brain, and measurement of intracranial pressure were introduced to explore individual management objectives for hypoxic-ischemic brain injury.


Cardiac arrest; Hypoxic-ischemic brain injury; Individual management; Cerebral monitoring

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Ying Feng,Xiaohua Zhang,Bo Sun,Minli Li. Individualized management objectives for hypoxic-ischemic brain injury after cardiac arrest. Signa Vitae. 2023. 19(4);20-30.


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