Article Data

  • Views 1619
  • Dowloads 172

Original Research

Open Access

Effects of early hyperbaric oxygen therapy with different frequencies on the nerve injury and vascular endothelial function in patients with acute cerebral infarction

  • Hanjing Lu1
  • Xianfa Liu1
  • Kun Yang2
  • Jiying Lai3
  • Qingfang He1
  • Hai Li4,*,

1Department of Emergency, The First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou, Jiangxi, China

2Department of Blood Transfusion, The First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou, Jiangxi, China

3ICU, The First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou, Jiangxi, China

4Department of Rehabilitation, The First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou, Jiangxi, China

DOI: 10.22514/sv.2022.074 Vol.18,Issue 6,November 2022 pp.76-80

Submitted: 09 August 2022 Accepted: 16 September 2022

Published: 08 November 2022

*Corresponding Author(s): Hai Li E-mail:


The therapeutic efficacy of multi-frequency hyperbaric oxygen therapy (HBOT) on neurological function and vascular endothelial function in patients with acute cerebral infarction (ACI) has not been demonstrated. In the present study, a total of 92 patients with ACI admitted to the emergency department and neurology department of the First Affiliated Hospital of Gannan Medical College were divided into a low-frequency and a high-frequency group, and HBOT was given once and twice a day, respectively, on the basis of routine drug treatment. The National Institutes of Health Stroke Scale (NIHSS) score, clinical outcomes, neurological function and vascular endothelial function before and after treatment were compared between the two groups, and the safety of treatment was evaluated. No deterioration or death was observed in both groups, and the overall effective rate of the high-frequency group was significantly higher than that of the low-frequency group (95.65% vs. 84.78%); NIHSS score and neuron-specific enolase (NSE) and brain-specific protein (S100-β) levels were significantly lower in the high-frequency group than those in the low-frequency group after one-month treatment; endothelin-1 (ET-1) level obviously decreased, whereas the levels of vascular endothelial growth factor (VEGF) and nitric oxide (NO) were significantly increased after 1 month of treatment in the high-frequency group, indicating better vascular endothelial function compared with that in the low-frequency group; the results of safety assessment showed that no serious adverse reactions occurred in both high-frequency and low-frequency groups. Therefore, early HBOT at a frequency of twice a day can not only effectively improve neurological function, but also have a restorative effect on vascular endothelial function in ACI, which is a safe and effective therapy.


ACI; HBOT; Neurological function; Vascular endothelial function; Safety

Cite and Share

Hanjing Lu,Xianfa Liu,Kun Yang,Jiying Lai,Qingfang He,Hai Li. Effects of early hyperbaric oxygen therapy with different frequencies on the nerve injury and vascular endothelial function in patients with acute cerebral infarction. Signa Vitae. 2022. 18(6);76-80.


[1] Bao L, Zhang S, Gong X, Cui G. Trousseau syndrome related cerebral infarction: clinical manifestations, laboratory findings and radiological features. Journal of Stroke and Cerebrovascular Diseases. 2020; 29: 104891.

[2] Chalos V, van der Ende NAM, Lingsma HF, Mulder MJHL, Venema E, Dijkland SA, et al. National institutes of health stroke scale: an alternative primary outcome measure for trials of acute treatment for ischemic stroke. Stroke. 2020; 51: 282–290.

[3] Chen CA, Huang YC, Lo JJ, Wang SH, Huang SH, Wu SH. Hyperbaric oxygen therapy attenuates burn-induced denervated muscle atrophy. International Journal of Medical Sciences. 2021; 18: 3821–3830.

[4] Edwards MD, Hughes TAT. Managing blood pressure in acute cerebral infarction. Journal of Neurology. 2021; 268: 2294–2296.

[5] Engel P, Ranieri M, Felthaus O, Geis S, Haubner F, Aung T, et al. Effect of HBO therapy on adipose-derived stem cells, fibroblasts and co-cultures: in vitro study of oxidative stress, angiogenic potential and production of pro-inflammatory growth factors in co-cultures1. Clinical Hemorheology and Microcirculation. 2021; 76: 459–471.

[6] Fernández E, Morillo V, Salvador M, Santafé A, Beato I, Rodríguez M, et al. Hyperbaric oxygen and radiation therapy: a review. Clinical and Translational Oncology. 2021; 23: 1047–1053.

[7] Ishihara A. Mild hyperbaric oxygen: mechanisms and effects. The Journal of Physiological Sciences. 2019; 69: 573–580.

[8] Jiang Y, Chen Y, Huang C, Xia A, Wang G, Liu S. Hyperbaric oxygen therapy improves neurological function via the p38-MAPK/CCL2 signaling pathway following traumatic brain injury. NeuroReport. 2021; 32: 1255–1262.

[9] Katsanos AH, Palaiodimou L, Zand R, Yaghi S, Kamel H, Navi BB, et al. The impact of SARS-CoV-2 on stroke epidemiology and care: a meta-analysis. Annals of Neurology. 2021; 89: 380–388.

[10] Lin KC, Chen KH, Wallace CG, Chen YL, Ko SF, Lee MS, et al. Combined therapy with hyperbaric oxygen and melatonin effectively reduce brain infarct volume and preserve neurological function after acute ischemic infarct in rat. Journal of Neuropathology and Experimental Neurology. 2019; 78: 949–960.

[11] Mistry EA, Yeatts SD, Khatri P, Mistry AM, Detry M, Viele K, et al. National institutes of health stroke scale as an outcome in stroke research: value of ANCOVA over analyzing change from baseline. Stroke. 2022; 53: e150–e155.

[12] Moghadam N, Hieda M, Ramey L, Levine BD, Guilliod R. Hyperbaric oxygen therapy in sports musculoskeletal injuries. Medicine & Science in Sports & Exercise. 2020; 52: 1420–1426.

[13] Nannoni S, de Groot R, Bell S, Markus HS. Stroke in COVID-19: a systematic review and meta-analysis. International Journal of Stroke. 2021; 16: 137–149.

[14] Resanović I, Zarić B, Radovanović J, Sudar-Milovanović E, Gluvić Z, Jevremović D, et al. Hyperbaric oxygen therapy and vascular complications in diabetes mellitus. Angiology. 2020; 71: 876–885.

[15] Sen S, Sen S. Therapeutic effects of hyperbaric oxygen: integrated review. Medical Gas Research. 2021; 11: 30–33.

[16] Shwe T, Bo-Htay C, Ongnok B, Chunchai T, Jaiwongkam T, Kerdphoo S, et al. Hyperbaric oxygen therapy restores cognitive function and hippocampal pathologies in both aging and aging-obese rats. Mechanisms of Ageing and Development. 2021; 195: 111465.

[17] Somaa F. A Review of the application of hyperbaric oxygen therapy in alzheimer’s disease. Journal of Alzheimer’s disease. 2021; 81: 1361–1367.

[18] Syahrul S, Maliga HA, Ilmawan M, Fahriani M, Mamada SS, Fajar JK, et al. Hemorrhagic and ischemic stroke in patients with coronavirus disease 2019: incidence, risk factors, and pathogenesis—a systematic review and meta-analysis. F1000Research. 2021; 10: 34.

[19] Tan Y, Goh C, Leow AST, Tambyah PA, Ang A, Yap E, et al. COVID-19 and ischemic stroke: a systematic review and meta-summary of the literature. Journal of Thrombosis and Thrombolysis. 2020; 50: 587–595.

[20] Wang LD, Xu ZM, Liang X, Qiu WR, Liu SJ, Dai LL, et al. Overview of systematic reviews of Panax notoginseng saponins in treatment of acute cerebral infarction. Zhongguo Zhong Yao Za Zhi. 2021; 46: 2963–2971.

[21] Wang YJ, Zhang SM, Zhang L, Wang CX, Dong Q, Gao S, et al. Chinese guidelines for the secondary prevention of ischemic stroke and transient ischemic attack 2010. CNS Neuroscience & Therapeutics. 2012; 18: 93–101.

[22] Xu ZM, Liang X, Dai LL, Wang YF, Liu SJ, Wang LD, et al. Evidence of clinical randomized controlled trial study in treatment of acute cerebral infarction with traditional Chinese medicine in recent five years. Zhongguo Zhong Yao Za Zhi. 2021; 46: 2942–2948.

[23] Yamal J, Grotta JC. National institutes of health stroke scale as an outcome measure for acute stroke trials. Stroke. 2021; 52: 142–143.

[24] Zhang T, Zhao J, Li X, Bai Y, Wang B, Qu Y, et al. Chinese stroke association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of stroke rehabilitation. Stroke and Vascular Neurology. 2020; 5: 250–259.

[25] Zhao H, Ge B, Yuan Y, Wang G. Hyperbaric oxygen ameliorated acute pancreatitis in rats via the mitochondrial pathway. Digestive Diseases and Sciences. 2020; 65: 3558–3569.

[26] Zhu Y, Zhu X, Chen Z, Cao X, Wang L, Zang L, et al. The efficacy of needle-warming moxibustion combined with hyperbaric oxygen therapy for ischemic stroke and its effect on neurological function. Computational and Mathematical Methods in Medicine. 2022; 2022: 1–7.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.0 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time