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Adjuvant therapies and sepsis from multidrug resistant bacteria: a narrative review

  • Vincenzo Pota1,*,
  • Francesco Coppolino1
  • Antonella Paladini2
  • Francesca Maglio1
  • Maria T. Sacco1
  • Vittoria Iorio1
  • Giuseppe S. Mangoni1
  • Fabiana Broccoli1
  • Maurizio Del Prete1
  • Pasquale Sansone1
  • Maria B. Passavanti1
  • Alfonso Barbarisi3
  • Caterina Aurilio1
  • Maria C. Pace1

1Department of women, child, general and specialistic surgery. University of Campania “L. Vanvitelli”, 80138 Naples, Italy

2Department of Clinical Medicine, Public health, Science of Life and environment. University of L’Aquila, 67100 L’Aquila, Italy

3Pegaso University, 80123 Naples, Italy

DOI: 10.22514/sv.2023.011

Submitted: 07 July 2022 Accepted: 28 October 2022

Online publish date: 16 February 2023

*Corresponding Author(s): Vincenzo Pota E-mail:


Sepsis represents one of the major health problem due to the high mortality rate and elevated health care costs. An important role in the genesis and the mechanisms sustaining sepsis has been found in the release of pro-inflammatory mediators. They are able to induce hemodynamic instability, end-organ dysfunction, and coagulation abnormalities. The host immune response involves a first extreme response to infective process that leads to tissue damage, organ failure and endothelial dysfunction. It was recently described the existence of a contrasting process, that is directed to restore homeostasis and it’s related with the release of anti-inflammatory mediators. The treatment of sepsis and septic shock could therefore benefit from the association of source control and antibiotic therapy with the use of drugs and other techniques, that act by modulating the cytokine storm. This approach is referred to an adjuvant therapy. The goal of this narrative review is to examine the various adjuvant therapies in the treatment of sepsis and septic shock.


Blood purification; Vitamin C; Thymosin; IVIg; GM-CSF; Interferon gamma

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Vincenzo Pota,Francesco Coppolino,Antonella Paladini,Francesca Maglio,Maria T. Sacco,Vittoria Iorio,Giuseppe S. Mangoni,Fabiana Broccoli,Maurizio Del Prete,Pasquale Sansone,Maria B. Passavanti,Alfonso Barbarisi,Caterina Aurilio,Maria C. Pace. Adjuvant therapies and sepsis from multidrug resistant bacteria: a narrative review. Signa Vitae. 2023.doi:10.22514/sv.2023.011.


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