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Original Research

Open Access

Role of lactate measurement in predicting recurrence of seizure within 24 hours in simple febrile seizure patients

  • Dongwook Lee1
  • Hyung Jun Moon1
  • Hyun Jung Lee1
  • Dongkil Jeong1
  • Hyun Joon Kim1
  • Hyun Noh2
  • Hye Young Jang3
  • Young Soon Cho2,*,

1Department of Emergency Medicine, Soonchunhyang University Cheonan Hospital, 31151 Cheonan, Republic of Korea

2Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, 14584 Bucheon, Republic of Korea

3Department of Emergency Medicine, Soonchunhyang University Seoul Hospital, 04401 Seoul, Republic of Korea

DOI: 10.22514/sv.2023.013

Submitted: 18 March 2022 Accepted: 07 May 2022

Online publish date: 22 February 2023

*Corresponding Author(s): Young Soon Cho E-mail:


Pediatric febrile seizure (FS) is classified into two types, simple febrile seizures (SFSs) and complex febrile seizures (CFSs). The prognosis of CFS and SFS is distinct from each other. Even after diagnosis of SFS, patients with recurrence of seizure within 24 hours are defined as CFS. And it is crucial to predict the recurrence of seizure in SFS patients. The purpose of this study was to investigate the role of lactate levels in predicting recurrence of seizure within 24 hours in SFS patients. This retrospective study was conducted on patients who visited the emergency department with FS from January 2017 to February 2020 at a single tertiary university hospital. They were divided into the recurrence group and the SFS group according to the recurrence of seizures. Multivariable analysis was performed to confirm whether lactate levels could be an independent factor in predicting recurrence of seizure within 24 hours in SFS patients. Of the 177 patients, 38 patients were classified into the recurrence group. High lactate levels (odds ratio = 1.45; 95%confidence interval: 1.04–2.03, p = 0.031) were found to be a significant factor in predicting recurrence of seizure within 24 hours in SFS patients. The areas under the ROC curve for lactate was 0.733. In patients with FS, high lactate levels were shown to be a useful and independent factor in predicting recurrence of seizure within 24 hours in SFS patients.


Lactate; Seizures; Febrile; Recurrence; Pediatric patient

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Dongwook Lee,Hyung Jun Moon,Hyun Jung Lee,Dongkil Jeong,Hyun Joon Kim,Hyun Noh,Hye Young Jang,Young Soon Cho. Role of lactate measurement in predicting recurrence of seizure within 24 hours in simple febrile seizure patients. Signa Vitae. 2023.doi:10.22514/sv.2023.013.


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