Article Data

  • Views 2113
  • Dowloads 172

Editorials

Open Access

Antiandrogen activity of drugs for COVID-19. The case of sabizabulin

  • Yuki Kotani1,2,3
  • Beatrice Righetti1
  • Mary Ann Belli1
  • Giovanni Landoni1,2,*,

1Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

2School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy

3Department of Intensive Care Medicine, Kameda Medical Center, 296-8602 Kamogawa, Japan

DOI: 10.22514/sv.2023.027 Vol.19,Issue 3,May 2023 pp.1-3

Submitted: 13 August 2022 Accepted: 18 October 2022

Published: 08 May 2023

*Corresponding Author(s): Giovanni Landoni E-mail: landoni.giovanni@hsr.it

Cite and Share

Yuki Kotani,Beatrice Righetti,Mary Ann Belli,Giovanni Landoni. Antiandrogen activity of drugs for COVID-19. The case of sabizabulin. Signa Vitae. 2023. 19(3);1-3.

References

[1] COVID-19 Treatment Guidelines Panel. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. 2022. Available at: https://www. covid19treatmentguidelines.nih.gov/ (Accessed: 06 September 2022).

[2] Gordon M, Skolnick A, Barnette KG. Phase II study of oral sabizabulin for the treatment of SARS-CoV-2 in hospitalised patients at high-risk for ARDS. 2022. Available at: https://online.eccmid.org/media-4157-phase-ii-study-of-oral-sabizabulin-forthe-treatment-of-sars-cov-2-in-hospitalised-patient (Accessed: 28 July 2022).

[3] Barnette KG, Gordon MS, Rodriguez D, Bird TG, Skolnick A, Schnaus M, et al. Oral sabizabulin for high-risk, hospitalized adults with Covid-19: interim analysis. NEJM Evidence. 2022; 1: EVIDoa2200145.

[4] Lee TC, Murthy S, Del Corpo O, Senécal J, Butler-Laporte G, Sohani ZN, et al. Remdesivir for the treatment of COVID-19: a systematic review and meta-analysis. Clinical Microbiology and Infection. 2022; 28: 1203–1210.

[5] The WHO Rapid Evidence Appraisal for COVID-19 Therapies Working Group; Shankar-Hari M, Vale CL, Godolphin PJ, Fisher D, Higgins JPT, Spiga F, et al. Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19: a meta-analysis. JAMA. 2021; 326: 499–518.

[6] Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181: 271–280.e8.

[7] Davey RA, Grossmann M. Androgen receptor structure, function and biology: from bench to bedside. Clinical Biochemist Reviews. 2016; 37: 3–15.

[8] Montopoli M, Zumerle S, Vettor R, Rugge M, Zorzi M, Catapano CV, et al. Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532). Annals of Oncology. 2020; 31: 1040–1045.

[9] Lyon M, Li J, Cullen J, Milinovich A, Kattan M, Jehi L, et al. 5α-reductase inhibitors are associated with reduced risk of SARS-CoV-2 infection: a matched-pair, registry-based analysis. Journal of Urology. 2022; 207: 183–189.

[10] Zangrillo A, Morselli F, Biagioni E, Di Stella R, Coloretti I, Moizo E, et al. Sex-related mortality differences in young adult septic shock patients. Signa Vitae. 2022; 1–7.

[11] Ghandehari S, Matusov Y, Pepkowitz S, Stein D, Kaderi T, Narayanan D, et al. Progesterone in addition to standard of care vs. standard of care alone in the treatment of men hospitalized with moderate to severe COVID-19. Chest. 2021; 160: 74–84.

[12] Nicastri E, Marinangeli F, Pivetta E, Torri E, Reggiani F, Fiorentino G, et al. A phase 2 randomized, double-blinded, placebo-controlled, multicenter trial evaluating the efficacy and safety of raloxifene for patients with mild to moderate COVID-19. EClinicalMedicine. 2022; 48: 101450.

[13] Cadegiani FA, McCoy J, Gustavo Wambier C, Goren A. Early antiandrogen therapy with dutasteride reduces viral shedding, inflam-matory responses, and time-to-remission in males with COVID-19: a randomized, double-blind, placebo-controlled interventional trial (EAT-DUTA AndroCoV Trial—Biochemical). Cureus. 2021; 13: e13047.


Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.0 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Conferences

Top