Article Data

  • Views 2039
  • Dowloads 324

Reviews

Open Access Special Issue

Perioperative right ventricular dysfunction in adult patients undergoing non-complex cardiac surgery: diagnosis and management

  • Andreja Möller Petrun1,2
  • Marko Zdravkovic1,2,3,*,
  • Robert Berger1
  • Denis Sraka1
  • Dusan Mekis1,2

1Department of anaesthesiology, intensive care and pain management, University Medical Centre Maribor, 2000 Maribor, Slovenia

2Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia

3Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia

DOI: 10.22514/sv.2023.047 Vol.19,Issue 5,September 2023 pp.11-22

Submitted: 31 October 2022 Accepted: 30 December 2022

Published: 08 September 2023

*Corresponding Author(s): Marko Zdravkovic E-mail: markozdravkovic@gmail.com

Abstract

Even though there is no precise consensus on definition of the right ventricular dysfunction and the right ventricular failure, their reported incidence after cardiac surgery ranges from 0.04% to 2.9%. Right ventricular dysfunction is clinically important because it has been consistently shown to have a negative impact on the perioperative outcomes. In this article we explore current evidence on perioperative diagnosis and management of adult patients with right ventricular dysfunction who are undergoing non-complex cardiac surgery. We propose criteria for the right ventricular dysfunction, describe its pathophysiological mechanisms, diagnostic and therapeutic options as well as current challenges. The function of the right ventricle is determined by preload, afterload, contractility, ventricular interdependence, and heart rhythm. These five factors should all be assessed in a particular patient. Right ventricular dysfunction is not always easy to confirm. Transthoracic and transesophageal echocardiography are the mainstay of diagnosis. Also, clinical and laboratory findings should be considered especially when the patient approaches the extreme of right ventricular dysfunction spectrum—right ventricular failure. Right ventricular failure should be anticipated, and management focused on its prevention and treatment of the underlying cause. The clinical aim is to optimise the volume status, minimise the right ventricular afterload, optimise right ventricular free wall and interventricular septum performance, and to maximise the left heart pressure work. If the patient does not respond to conservative therapy, mechanical support should be promptly considered.


Keywords

Right ventricle; Right ventricular dysfunction; Right ventricular failure; Heart failure; Cardiac surgery; Management; Diagnosis; Definition


Cite and Share

Andreja Möller Petrun,Marko Zdravkovic,Robert Berger,Denis Sraka,Dusan Mekis. Perioperative right ventricular dysfunction in adult patients undergoing non-complex cardiac surgery: diagnosis and management. Signa Vitae. 2023. 19(5);11-22.

References

[1] Wencker D, Borer JS, Hochreiter C, Devereux RB, Roman MJ, Kligfield P, et al. Preoperative predictors of late post-operative outcome among patients with nonischemic mitral regurgitation with “high risk” descriptors and comparison with unoperated patients. Cardiology. 2000; 93: 37–42.

[2] Maslow AD, Regan MM, Panzica P, Heindel S, Mashikian J, Comunale ME. Precardiopulmonary bypass right ventricular function is associated with poor outcome after coronary artery bypass grafting in patients with severe left ventricular systolic dysfunction. Anesthesia & Analgesia. 2002; 95: 1507–1518.

[3] Peyrou J, Chauvel C, Pathak A, Simon M, Dehant P, Abergel E. Preoperative right ventricular dysfunction is a strong predictor of 3 years survival after cardiac surgery. Clinical Research in Cardiology. 2017; 106: 734–742.

[4] Kaul TK, Fields BL. Postoperative acute refractory right ventricular fail-ure: incidence, pathogenesis, management and prognosis. Cardiovascular Surgery. 2000; 8: 1–9.

[5] Chou J, Ma M, Gylys M, Seong J, Salvatierra N, Kim R, et al. Preexisting right ventricular dysfunction is associated with higher postoperative cardiac complications and longer hospital stay in high-risk patients undergoing nonemergent major vascular surgery. Journal of Cardiothoracic and Vascular Anesthesia. 2019; 33: 1279–1286.

[6] Haddad F, Doyle R, Murphy DJ, Hunt SA. Right ventricular function in cardiovascular disease, part II. Circulation. 2008; 117: 1717–1731.

[7] Denault AY, Haddad F, Jacobsohn E, Deschamps A. Perioperative right ventricular dysfunction. Current Opinion in Anaesthesiology. 2013; 26: 71–81.

[8] Ventetuolo CE, Klinger JR. Management of acute right ventricular failure in the intensive care unit. Annals of the American Thoracic Society. 2014; 11: 811–822.

[9] Guarracino F, Bertini P, Pinsky MR. Right ventriculo-arterial coupling in the critically ill. Annual Update in Intensive Care and Emergency Medicine. 2017; 250: 203–209.

[10] McCall PJ, Willder JM, Stanley BL, Messow CM, Allan J, Gemmell L, et al. Right ventricular dysfunction in patients with COVID-19 pneumonitis whose lungs are mechanically ventilated: a multicentre prospective cohort study. Anaesthesia. 2022; 77: 772–784.

[11] Corica B, Marra AM, Basili S, Cangemi R, Cittadini A, Proietti M, et al. Prevalence of right ventricular dysfunction and impact on all-cause death in hospitalized patients with COVID-19: a systematic review and meta-analysis. Scientific Reports. 2021; 11: 17774.

[12] Flower L, Parulekar P, Roshdy A. The challenges of defining right ventricular dysfunction in critical illness. Anaesthesia. 2022; 77: 1307–1308.

[13] Simonneau G, Montani D, Celermajer DS, Denton CP, Gatzoulis MA, Krowka M, et al. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. European Respiratory Journal. 2019; 53: 1801913.

[14] Hoeper MM, Humbert M. The new haemodynamic definition of pulmonary hypertension: evidence prevails, finally! European Respiratory Journal. 2019; 53: 1900038.

[15] D’Alto M, Marra AM, Severino S, Salzano A, Romeo E, De Rosa R, et al. Right ventricular-arterial uncoupling independently predicts survival in COVID-19 ARDS. Critical Care. 2020; 24: 670.

[16] Al-Omary MS, Sugito S, Boyle AJ, Sverdlov AL, Collins NJ. Pulmonary hypertension due to left heart disease. Hypertension. 2020; 75: 1397–1408.

[17] Arrigo M, Huber LC, Winnik S, Mikulicic F, Guidetti F, Frank M, et al. Right ventricular failure: pathophysiology, diagnosis and treatment. Cardiac Failure Review. 2019; 5: 140–146.

[18] Hochman JS, Sleeper LA, Webb JG, Sanborn TA, White HD, Talley JD, et al. Early revascularization in acute myocardial infarction complicated by cardiogenic shock. New England Journal of Medicine. 1999; 341: 625–634.

[19] Mehta SR, Eikelboom JW, Natarajan MK, Diaz R, Yi C, Gibbons RJ, et al. Impact of right ventricular involvement on mortality and morbidity in patients with inferior myocardial infarction. Journal of the American College of Cardiology. 2001; 37: 37–43.

[20] Antman EM, Anbe DT, Armstrong PW, Bates ER, Green LA, Hand M, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction—executive summary. Circulation. 2004; 110: 588–636.

[21] Sagristà-Sauleda J, Angel J, Sambola A, Permanyer-Miralda G. Hemo-dynamic effects of volume expansion in patients with cardiac tamponade. Circulation. 2008; 117: 1545–1549.

[22] Kucher N, Goldhaber SZ. Management of massive pulmonary embolism. Circulation. 2005; 112: e28–32.

[23] Ismail I, Cebotari S, Busse A, Martens A, Shrestha M, Kühn C, et al. Right-sided heart failure and extracorporeal life support in patients undergoing pericardiectomy for constrictive pericarditis: a risk factor analysis for adverse outcome. The Thoracic and Cardiovascular Surgeon. 2017; 65: 662–670.

[24] Jin Y, Wang H, Wang Z, Jiang H, Tao D, Wu H. The evaluation of preoperative right ventricular diastolic dysfunction on coronary artery disease patients with left ventricular dysfunction. Echocardiography. 2014; 31: 1259–1264.

[25] Sumin AN, Korok EV, Sergeeva TJ. Preexisting right ventricular diastolic dysfunction and postoperative cardiac complications in patients undergoing nonemergency coronary artery bypass surgery. Journal of Cardiothoracic and Vascular Anesthesia. 2021; 35: 799–806.

[26] Stickel S, Gin-Sing W, Wagenaar M, Gibbs JSR. The practical management of fluid retention in adults with right heart failure due to pulmonary arterial hypertension. European Heart Journal Supplements. 2019; 21: K46–K53.

[27] Konstam MA, Kiernan MS, Bernstein D, Bozkurt B, Jacob M, Kapur NK, et al. Evaluation and management of right-sided heart failure: a scientific statement from the American Heart Association. Circulation. 2018; 137: e578–e622.

[28] Harjola V, Mebazaa A, Čelutkienė J, Bettex D, Bueno H, Chioncel O, et al. Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the working group on pulmonary circulation and right ventricular function of the European society of cardiology. European Journal of Heart Failure. 2016; 18: 226–241.

[29] Vlahakes GJ. Right ventricular failure after cardiac surgery. Cardiology Clinics. 2012; 30: 283–289.

[30] Yanagida R, Rajagopalan N, Davenport DL, Tribble TA, Bradley MA, Hoopes CW. Delayed sternal closure does not reduce complications associated with coagulopathy and right ventricular failure after left ventricular assist device implantation. Journal of Artificial Organs. 2018; 21: 46–51.

[31] Disselkamp M, Adkins D, Pandey S, Coz Yataco AO. Physiologic approach to mechanical ventilation in right ventricular failure. Annals of the American Thoracic Society. 2018; 15: 383–389.

[32] Forrest P. Anaesthesia and right ventricular failure. Anaesthesia and Intensive Care. 2009; 37: 370–385.

[33] Grübler MR, Wigger O, Berger D, Blöchlinger S. Basic concepts of heart-lung interactions during mechanical ventilation. Swiss Medical Weekly. 2017; 147: w14491.

[34] Keebler ME, Haddad EV, Choi CW, McGrane S, Zalawadiya S, Schlendorf KH, et al. Venoarterial extracorporeal membrane oxygenation in cardiogenic shock. JACC: Heart Failure. 2018; 6: 503–516.

[35] Raffa GM, Kowalewski M, Brodie D, Ogino M, Whitman G, Meani P, et al. Meta-analysis of peripheral or central ECMO in postcardiotomy and non-postcardiotomy shock. The Annals of Thoracic Surgery. 2019; 107: 311–321.

[36] Lorusso R, Raffa GM, Alenizy K, Sluijpers N, Makhoul M, Brodie D, et al. Structured review of post-cardiotomy extracorporeal membrane oxygenation: part 1—adult patients. The Journal of Heart and Lung Transplantation. 2019; 38: 1125–1143.

[37] Guglin M, Zucker MJ, Bazan VM, Bozkurt B, El Banayosy A, Estep JD, et al. Venoarterial ECMO for adults. Journal of the American College of Cardiology. 2019; 73: 698–716.

[38] Levy D, Laghlam D, Estagnasie P, Brusset A, Squara P, Nguyen LS. Post-operative right ventricular failure after cardiac surgery: a cohort study. Frontiers in Cardiovascular Medicine. 2021; 8: 667328.

[39] Green EM, Givertz MM. Management of acute right ventricular failure in the intensive care unit. Current Heart Failure Reports. 2012; 9: 228–235.

[40] Khoury H, Lyons R, Sanaiha Y, Rudasill S, Shemin RJ, Benharash P. Deep venous thrombosis and pulmonary embolism in cardiac surgical patients. The Annals of Thoracic Surgery. 2020; 109: 1804–1810.

[41] Estrada VHN, Franco DLM, Moreno AAV, Gambasica JAR, Nunez CCC. Postoperative right ventricular failure in cardiac surgery. Cardiology Research. 2016; 7: 185–195.

[42] Itagaki S, Hosseinian L, Varghese R. Right ventricular failure after cardiac surgery: management strategies. Seminars in Thoracic and Cardiovascular Surgery. 2012; 24: 188–194.

[43] Colombo PC, Onat D, Harxhi A, Demmer RT, Hayashi Y, Jelic S, et al. Peripheral venous congestion causes inflammation, neurohormonal, and endothelial cell activation. European Heart Journal. 2014; 35: 448–454.

[44] Martell M. Physiopathology of splanchnic vasodilation in portal hyper-tension. World Journal of Hepatology. 2010; 2: 208.

[45] Voelkel NF, Quaife RA, Leinwand LA, Barst RJ, McGoon MD, Meldrum DR, et al. Right ventricular function and failure. Circulation. 2006; 114: 1883–1891.

[46] Girerd N, Seronde M, Coiro S, Chouihed T, Bilbault P, Braun F, et al. Integrative assessment of congestion in heart failure throughout the patient journey. JACC: Heart Failure. 2018; 6: 273–285.

[47] Pellicori P, Platz E, Dauw J, Maaten JM, Martens P, Pivetta E, et al. Ultrasound imaging of congestion in heart failure: examinations beyond the heart. European Journal of Heart Failure. 2021; 23: 703–712.

[48] Wanner PM, Filipovic M. The right ventricle—you may forget it, but it will not forget you. Journal of Clinical Medicine. 2020; 9: 432.

[49] Sato T, Tsujino I, Ohira H, Oyama-Manabe N, Yamada A, Ito YM, et al. Validation study on the accuracy of echocardiographic measurements of right ventricular systolic function in pulmonary hypertension. Journal of the American Society of Echocardiography. 2012; 25: 280–286.

[50] Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American society of echocardiography and the European association of cardiovascular imaging. European Heart Journal—Cardiovascular Imaging. 2015; 16: 233–271.

[51] Rosenkranz S, Preston IR. Right heart catheterisation: best practice and pitfalls in pulmonary hypertension. European Respiratory Review. 2015; 24: 642–652.

[52] Gupta L, Kerai S, Gupta B, Kakkar K. Role of high-flow nasal oxygen therapy in cases with pulmonary hypertension in an intensive care unit setting. Indian Journal of Critical Care Medicine. 2019; 23: 458–461.

[53] Varma PK, Srimurugan B, Jose RL, Krishna N, Valooran GJ, Jayant A. Perioperative right ventricular function and dysfunction in adult cardiac surgery—focused review (part 2—management of right ventricular failure). Indian Journal of Thoracic and Cardiovascular Surgery. 2022; 38: 157–166.

[54] Jentzer JC, Coons JC, Link CB, Schmidhofer M. Pharmacotherapy update on the use of vasopressors and inotropes in the intensive care unit. Journal of Cardiovascular Pharmacology and Therapeutics. 2015; 20: 249–260.

[55] Pelletier J, Dicken B, Bigam D, Cheung P. Cardiac effects of vasopressin. Journal of Cardiovascular Pharmacology. 2014; 64: 100–107.

[56] Moller PW, Winkler B, Hurni S, Heinisch PP, Bloch A, Sondergaard S, et al. Right atrial pressure and venous return during cardiopulmonary by-pass. American Journal of Physiology-Heart and Circulatory Physiology. 2017; 313: H408–H420.

[57] Kholdani CA, Fares WH. Management of right heart failure in the intensive care unit. Clinics in Chest Medicine. 2015; 36: 511–520.

[58] Solina AR, Ginsberg SH, Papp D, Grubb WR, Scholz PM, Pantin EJ, et al. Dose response to nitric oxide in adult cardiac surgery patients. Journal of Clinical Anesthesia. 2001; 13: 281–286.

[59] Yu B, Ichinose F, Bloch DB, Zapol WM. Inhaled nitric oxide. British Journal of Pharmacology. 2019; 176: 246–255.

[60] Price LC, Wort SJ, Finney SJ, Marino PS, Brett SJ. Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review. Critical Care. 2010; 14: R169.

[61] Papp Z, Agostoni P, Alvarez J, Bettex D, Bouchez S, Brito D, et al. Levosimendan efficacy and safety: 20 years of SIMDAX in clinical use. Journal of Cardiovascular Pharmacology. 2020; 76: 4–22.

[62] Al-Chalabi A, Heunks LMA, Papp Z, Pollesello P. Potential of the cardiovascular drug levosimendan in the management of amyotrophic lateral sclerosis. Journal of Cardiovascular Pharmacology. 2019; 74: 389–399.

[63] Qiu J, Jia L, Hao Y, Huang S, Ma Y, Li X, et al. Efficacy and safety of levosimendan in patients with acute right heart failure: a meta-analysis. Life Sciences. 2017; 184: 30–36.

[64] Chong LYZ, Satya K, Kim B, Berkowitz R. Milrinone dosing and a culture of caution in clinical practice. Cardiology in Review. 2018; 26: 35–42.

[65] Ruffolo RR. The pharmacology of dobutamine. The American Journal of the Medical Sciences. 1987; 294: 244–248.

[66] Andersen S, Andersen A, de Man FS, Nielsen-Kudsk JE. Sympathetic nervous system activation and β-adrenoceptor blockade in right heart failure. European Journal of Heart Failure. 2015; 17: 358–366.

[67] Kapur NK, Esposito ML, Bader Y, Morine KJ, Kiernan MS, Pham DT, et al. Mechanical circulatory support devices for acute right ventricular failure. Circulation. 2017; 136: 314–326.

[68] Kuroda T, Miyagi C, Fukamachi K and Karimov JH. Mechanical circulatory support devices and treatment strategies for right heart failure. Frontiers in Cardiovascular Medicine. 2022; 9: 951234.

[69] Abdelshafy M, Caliskan K, Guven G, Elkoumy A, Elsherbini H, Elzomor H, et al. Temporary right-ventricular assist devices: a systematic review. Journal of Clinical Medicine. 2022; 11: 613.

[70] Makdisi G, Wang I. Extra corporeal membrane oxygenation (ECMO) review of a lifesaving technology. Journal of Thoracic Disease. 2015; 7: E166–176.

[71] Ratnani I, Tuazon D, Zainab A, Uddin F. The role and impact of extracorporeal membrane oxygenation in critical care. Methodist DeBakey Cardiovascular Journal. 2018; 14: 110–119.

[72] Djordjevic I, Eghbalzadeh K, Sabashnikov A, Deppe AC, Kuhn EW, Seo J, et al. Single center experience with patients on veno arterial ECMO due to postcardiotomy right ventricular failure. Journal of Cardiac Surgery. 2020; 35: 83–88.

[73] Lorusso R, Whitman G, Milojevic M, Raffa G, McMullan DM, Boeken U, et al. 2020 EACTS/ELSO/STS/AATS expert consensus on post-cardiotomy extracorporeal life support in adult patients. European Journal of Cardio-Thoracic Surgery. 2021; 59: 12–53.

[74] Pappalardo F, Schulte C, Pieri M, Schrage B, Contri R, Soeffker G, et al. Concomitant implantation of Impella® on top of veno-arterial extracorporeal membrane oxygenation may improve survival of patients with cardiogenic shock. European Journal of Heart Failure. 2017; 19: 404–412.


Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.0 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Conferences

Top