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Original Research

Open Access

Effect of hemocoagulase on the coagulation parameters, blood transfusion volume and bleeding volume of patients with severe traumatic fractures

  • Haiyang Zhao1,*,
  • Jingyuan Si2
  • Hongmin Guo3
  • Xiaoming Li4
  • Jinzhu Wang1

1Department of Severe Trauma Orthopedics, The Affiliated Hospital of Chengde Medical University, 067000 Chengde, Hebei, China

2Operating Room, The Affiliated Hospital of Chengde Medical University, 067000 Chengde, Hebei, China

3Department of Emergency, Chengde Central Hospital, 067000 Chengde, Hebei, China

4Department of Orthopedics, Xinglong Count People’s Hospital, 067399 Chengde, Hebei, China

DOI: 10.22514/sv.2023.054 Vol.19,Issue 4,July 2023 pp.104-108

Submitted: 28 September 2022 Accepted: 12 December 2022

Published: 08 July 2023

*Corresponding Author(s): Haiyang Zhao E-mail: zhaohaiyang_vv@163.com

Abstract

To investigate the effect of hemocoagulase on coagulation parameters, blood transfusion volume and bleeding volume in patients with severe traumatic fractures. A total of 116 patients with severe traumatic fractures admitted to our hospital. These patients were randomly divided into the study group (hemocoagulase injection) and control group (normal saline injection), with 58 patients in each group. The bleeding time, coagulation time, perioperative bleeding volume, blood transfusion volume, hematology and coagulation parameters of the two groups were observed and compared. At 24 h post-surgery, the bleeding time and coagulation time were significantly shorter in the study group than in the control group (p < 0.05). The intraoperative bleeding volume, 24 h postoperative drainage volume, and blood transfusion volume were significantly lower in the study group than in the control group (p < 0.05). In addition, the 24 h postoperative levels of hematology parameters were significantly higher in the study group than in the control group (p < 0.05). However, coagulation parameters were similar in both groups before and at 24 h after surgery. Hemocoagulase has a better hemostatic effect and can effectively reduce perioperative bleeding without affecting the coagulation functions of patients with severe traumatic fractures. Therefore, hemocoagulase is a reliable treatment regimen in clinical practice.


Keywords

Hemocoagulase; Severe traumatic fracture; Coagulation function; Blood transfusion volume; Bleeding volume


Cite and Share

Haiyang Zhao,Jingyuan Si,Hongmin Guo,Xiaoming Li,Jinzhu Wang. Effect of hemocoagulase on the coagulation parameters, blood transfusion volume and bleeding volume of patients with severe traumatic fractures. Signa Vitae. 2023. 19(4);104-108.

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