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Original Research

Open Access

Comparison of clinical efficacy and safety between intravenous thrombolysis and endovascular therapy in patients with acute large vessel occlusion stroke of the posterior circulation

  • Jianmei Cai1
  • Guangjun Xi1
  • Zheng Dai1,*,

1Department of Neurology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, 214023 Wuxi, Jiangsu, China

DOI: 10.22514/sv.2023.055 Vol.19,Issue 4,July 2023 pp.129-134

Submitted: 23 November 2022 Accepted: 04 January 2023

Published: 08 July 2023

*Corresponding Author(s): Zheng Dai E-mail:


To investigate the efficacy and safety of intravenous thrombolytic (IVT) therapy and endovascular (EV) therapy in patients with acute posterior large vessel occlusion stroke (PLVOS). A total of fifty patients with acute PLVOS were randomly divided into the IVT group and EV group. The general baseline data, post-treatment vascular recanalization rate, National Institute of Health Stroke Scale (NIHSS) score before and after intervention, prognosis, and perioperative complications were compared between the two groups. There were no significant differences in the overall baseline data between the two groups (p > 0.05). The post-treatment recanalization rate was significantly higher in the EV group (88.00%) than in the IVT group (64.00%, p < 0.05). The NIHSS score at 24 h post-admission was significantly lower and prognosis was significantly better in the EV group than in the IVT group (both p < 0.05). The EV group had significantly lower overall complication rate (16.00%) than the IVT group (48.00%, p < 0.05). Compared with IVT therapy, EV therapy can effectively improve neurological damage, vascular recanalization rate and prognosis as well as reduce the incidence of perioperative complications in patients with acute PLVOS.


Acute posterior large vessel occlusion stroke; Intravenous thrombolytic therapy; Endovascular therapy; Recanalization rate; Safety evaluation

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Jianmei Cai,Guangjun Xi,Zheng Dai. Comparison of clinical efficacy and safety between intravenous thrombolysis and endovascular therapy in patients with acute large vessel occlusion stroke of the posterior circulation. Signa Vitae. 2023. 19(4);129-134.


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