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Original Research

Open Access

Effect of volume-controlled and pressure-controlled ventilation modes on cerebral oximetry in laparoscopic cholecystectomy: a randomized controlled trial

  • Emre Badur1
  • Mustafa Altınay1,*,
  • Ayşe Surhan Çınar1
  • Leyla Türkoğlu1
  • Tuğba Yücel1

1Anesthesiology and Reanimation Department, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, 34371 Istanbul, Turkey

DOI: 10.22514/sv.2023.098

Submitted: 22 July 2023 Accepted: 18 August 2023

Online publish date: 23 October 2023

*Corresponding Author(s): Mustafa Altınay E-mail:


This study aimed to compare the effect of volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) modes on cerebral oximetry during laparoscopic cholecystectomy using near-infrared spectroscopy (NIRS). Seventy patients who underwent elective laparoscopic cholecystectomy were randomized to receive either VCV (group V) or PCV (group P). Demographic and operative data (anesthesia, surgery and insufflation durations) were recorded. The primary outcome was the NIRS value, while the secondary outcomes were peripheral oxygen saturation (SpO2), blood gas parameters and peak and plateau pressures in mechanical ventilation. Measurements were conducted at the start of anesthesia (T0), end of intubation (T1), 5 min after insufflation (T2), just before desufflation (T3), and 5 min after desufflation (T4). Both groups were comparable in terms of age, sex, body mass index, intraoperative time, anesthesia and insufflation durations. The average NIRS right T1–T2–T3 and left T2–T3 values were significantly higher in group P than in group V (p = 0.030, p = 0.001, p = 0.001, p = 0.006 and p = 0.002 respectively). In contrast, the mean peak and mean plateau pressures in group P at T1, T2 and T4 were significantly lower than those in group V (p = 0.003, p = 0.001, p < 0.001, p = 0.011, p = 0.001 and p < 0.001 respectively).The PCV mode allows better cerebral oxygenation than VCV while maintaining lower peak pressure and plateau pressures.


Laparoscopic cholecystectomy; Mechanical ventilation; Near-infrared spectroscopy

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Emre Badur,Mustafa Altınay,Ayşe Surhan Çınar,Leyla Türkoğlu,Tuğba Yücel. Effect of volume-controlled and pressure-controlled ventilation modes on cerebral oximetry in laparoscopic cholecystectomy: a randomized controlled trial. Signa Vitae. 2023.doi:10.22514/sv.2023.098.


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