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Original Research

Open Access

The effect of non-invasive sequential ventilation treatment based on the use of an invasive ventilator on the arterial blood gas and inflammatory stress reaction in patients with severe pneumonia with respiratory failure

  • Jianfeng Gong1,*,
  • Xiang Yang1
  • Jingfen Xiang2
  • Huali Zhou3
  • Weiliang Wu1

1Department of Critical Care Medicine, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, 511500 Qingyuan, Guangdong, China

2Department of Emergency, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, 511500 Qingyuan, Guangdong, China

3Department of Plastic and Cosmetic Surgery, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, 511500 Qingyuan, Guangdong, China

DOI: 10.22514/sv.2023.105 Vol.19,Issue 6,November 2023 pp.121-126

Submitted: 30 June 2023 Accepted: 10 October 2023

Published: 08 November 2023

*Corresponding Author(s): Jianfeng Gong E-mail: jfgong1363@163.com

Abstract

To investigate the impact of non-invasive sequential ventilation treatment based on the use of an invasive ventilator on the arterial blood gas and inflammatory stress reaction in patients with severe pneumonia with respiratory failure. Ninety patients with severe pneumonia and respiratory failure were equally separated into two groups via a random number table: a conventional treatment group (subjected to invasive mechanical ventilation) and a study group (subjected to invasive mechanical ventilation and non-invasive sequential ventilation treatment). We compared the two groups with respect to several key parameters before and after treatment, including mechanical ventilation time, invasive ventilation time, intensive care unit (ICU) stay, hospital stay, blood gas analysis indicators and the levels of inflammatory factors in the serum. We also compared the two groups with regards to complications. Mechanical ventilation time, invasive ventilation time, ICU stay and hospital stay in the study group were significantly shorter than that in the conventional treatment group (p < 0.05). Arterial Oxygen Saturation (SaO2), Partial Pressure of Oxygen (PaO2) and pH in the study group after intervention were significantly higher than those in the conventional treatment group after intervention (p < 0.05). Following intervention, white blood cell (WBC), serum c-reactive protein (CRP) and serum interleukin-6 (IL-6) were significantly lower than those in the conventional treatment group (p < 0.05). The total incidence of complications in the study group was markedly lower than in the conventional treatment group. Non-invasive sequential ventilation therapy based on an invasive ventilator had a significant treatment impact on patients with severe pneumonia and respiratory failure. This treatment effectively reduced the average treatment time, improved blood gas analysis indicators and reduced inflammatory stress, thus reducing the incidence of complications.


Keywords

Severe pneumonia; Respiratory failure; Invasive mechanical ventilation; Non-invasive sequential ventilation; Blood gas analysis; Inflammatory factor


Cite and Share

Jianfeng Gong,Xiang Yang,Jingfen Xiang,Huali Zhou,Weiliang Wu. The effect of non-invasive sequential ventilation treatment based on the use of an invasive ventilator on the arterial blood gas and inflammatory stress reaction in patients with severe pneumonia with respiratory failure. Signa Vitae. 2023. 19(6);121-126.

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