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Original Research

Open Access

SESN1, as a potential target for postoperative cognitive dysfunction, attenuates sevoflurane-induced neuronal cell damage in the hippocampus

  • Li Sun1
  • Xiaoya Hong1
  • Yangyang Li1
  • Daliang Wang1,*,

1Department of Anesthesiology, The Affiliated Huai’an No. 1 People's Hospital of Nanjing Medical University, 223000 Huai’an, Jiangsu, China

DOI: 10.22514/sv.2023.107 Vol.19,Issue 6,November 2023 pp.137-143

Submitted: 25 July 2023 Accepted: 22 August 2023

Published: 08 November 2023

*Corresponding Author(s): Daliang Wang E-mail:


Postoperative cognitive dysfunction (POCD) is a devastating complication with long-term consequences, and new therapeutic targets and drugs are still needed for the treatment of POCD. Sestrin are a family of stress-inducing proteins that regulate cellular metabolic networks. However, the possible effects of Sestrin on POCD were still unclear. This study aimed to investigate the effects of Sestrin 1 (SESN1) in postoperative cognitive dysfunction (POCD) cell model and reveal its mechanism. We constructed an in vitro model of POCD by treating primary rat hippocampal neurons with sevoflurane. Herein, we noticed SESN1 enhanced cell viability induced by sevoflurane. Further, SESN1 improved sevoflurane-induced cell inflammation. We further found that SESN1 improved sevoflurane induced reactive oxygen species (ROS) production and inhibited apoptosis. Mechanically, SESN1 restrained NOD-like receptor thermal protein domain 3 (NLRP3) inflammasome activation and therefore suppressed POCD. In conclusion, SESN1, as a potential target for postoperative cognitive dysfunction, attenuates sevoflurane-induced neuronal cell damage in the hippocampus. These findings will provide guidance for the mechanism study of POCD and future drug development for treatment of POCD.


Postoperative cognitive dysfunction (POCD); Sestrin 1 (SESN1); Inflammation; Sevoflurane; NLRP3 inflammasome

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Li Sun,Xiaoya Hong,Yangyang Li,Daliang Wang. SESN1, as a potential target for postoperative cognitive dysfunction, attenuates sevoflurane-induced neuronal cell damage in the hippocampus. Signa Vitae. 2023. 19(6);137-143.


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