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Original Research

Open Access

Tussilagone inhibits inflammation and oxidative stress to alleviate acute pancreatitis

  • Chuan Zhang1
  • Mingrong Xie2,*,
  • Yanmei Wang3
  • Tingyong Han1

1Department of Emergency, Ya’An Polytechnic College Affiliated Hospital, 625000 Ya’An, Sichuan, China

2Department of Gastroenterology, Ya’An People’s Hospital, 625000 Ya’An, Sichuan, China

3Department of Endocrinology, Ya’An Polytechnic College Affiliated Hospital, 625000 Ya’An, Sichuan, China

DOI: 10.22514/sv.2024.009 Vol.20,Issue 1,January 2024 pp.133-139

Submitted: 14 November 2023 Accepted: 14 December 2023

Published: 08 January 2024

*Corresponding Author(s): Mingrong Xie E-mail: Xiemingrong_666@163.com

Abstract

Acute pancreatitis (AP) is a clinical emergency characterized by elevated levels of inflammation and oxidative stress, urging the need for the development of new and more efficacious treatments. Tussilagone (TSL), a compound from Tussilago farfara flower buds, is known to exhibit diverse properties, including anti-inflammatory activity, but its precise role in AP remains unclear. In this study, we investigated TSL’s impact on the progression of AP. To establish AP animal models, mice were intraperitoneally administered hyranolin. Our findings demonstrate that TSL effectively suppresses the progression of AP in these mice and decreases inflammation in their pancreatic tissues, as evidenced by reduced secretion of inflammatory cytokines such as interleukin (IL)-1β, Tumor necrosis factor (TNF)-α and IL-6 (p < 0.05). Notably, TSL also mitigates neutrophil infiltration into the pancreatic tissues of AP-afflicted mice and alleviates oxidative stress in AP mice, as confirmed by the measurements of Superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), and myeloperoxidase (MPO) (p < 0.05). Remarkably, TSL exerts its inhibitory effects on inflammation and oxidative stress by blocking the nuclear factor (NF)-κB pathway and activating the NF-E2-related factor 2 (Nrf2) pathway. In conclusion, TSL can mitigate inflammation and oxidative stress, offering potential as a promising therapeutic agent for AP.


Keywords

Acute pancreatitis (AP); Tussilagone; Neutrophil infiltration


Cite and Share

Chuan Zhang,Mingrong Xie,Yanmei Wang,Tingyong Han. Tussilagone inhibits inflammation and oxidative stress to alleviate acute pancreatitis. Signa Vitae. 2024. 20(1);133-139.

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