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Original Research

Open Access

Effects of western medicine and Huangqi Taizishen Chenpi decoction on the treatment of severe pneumonia in children

  • Xiulu Yang1
  • Jun Xiang2
  • Lianlian Ji3
  • Weimin Jin3,*,

1Department of Ultrasound, Ruian Maternity and Child Care Hospital, 325200 Wenzhou, Zhejiang, China

2Department of Chinese Pediatrics, The Third Affiliated Hospital of Wenzhou Medical University, 325200 Wenzhou, Zhejiang, China

3Department of Pediatrics, The Third Affiliated Hospital of Wenzhou Medical University, 325200 Wenzhou, Zhejiang, China

DOI: 10.22514/sv.2024.043 Vol.20,Issue 4,April 2024 pp.68-74

Submitted: 03 January 2024 Accepted: 28 February 2024

Published: 08 April 2024

*Corresponding Author(s): Weimin Jin E-mail: wm_jin1229@163.com

Abstract

To investigate the effects of Western medicine and Huangqi Taizishen Chenpi decoction on treating severe pneumonia in children. This study involved 100 children diagnosed with severe pneumonia and treated at our hospital from January 2021 to September 2023. They were randomly assigned into two groups: an experimental group (n = 50; received Huangqi Taizishen Chenpi decoction, a traditional Chinese medicine formulation) and a control group (n = 50; received conventional Western medical treatment). Then, the clinical outcomes between these two treatment modalities were compared. Among the 100 patients, 71 (71%) were infected by a single pathogen, with respiratory syncytial virus, rhinovirus and Pseudomonas aeruginosa being the most common pathogens identified. The experimental group exhibited a significantly higher overall effective treatment rate (98%) compared to the control group (84%) (p < 0.05). Additionally, the experimental group had significantly shorter hospital stays (11.30 ± 1.59 days), quicker resolution of lung rales (5.60 ± 1.70 days), and faster symptom improvement times (8.50 ± 1.91 days) than the control group (14.60 ± 2.08 days, 7.80 ± 2.33 days, 10.70 ± 2.13 days respectively) (p < 0.05). Post-treatment lung function tests, including Forced Vital Capacity (FVC) (2.76 ± 0.50 L), Maximum Mid-Expiratory Flow (MMF)(1.83 ± 0.56 L/s), and Forced Expiratory Volume in 1 second (FEV1) (2.25 ± 0.46 L), were significantly improved in the experimental group compared to the control group (2.41 ± 0.40 L, 1.43 ± 0.43 L/s, 1.87 ± 0.35 L respectively) (p < 0.05). The rate of adverse reactions in the experimental group was significantly lower (6%) compared to the control group (16%) (p < 0.05). Huangqi Taizishen Chenpi decoction significantly improves treatment outcomes in children with severe pneumonia, reduces the recovery period, and enhances the restoration of bodily functions with fewer adverse reactions, thereby demonstrating promising clinical significance.


Keywords

Western medicine; Huangqi Taizishen Chenpi decoction; Severe pneumonia in children


Cite and Share

Xiulu Yang,Jun Xiang,Lianlian Ji,Weimin Jin. Effects of western medicine and Huangqi Taizishen Chenpi decoction on the treatment of severe pneumonia in children. Signa Vitae. 2024. 20(4);68-74.

References

[1] Chisti MJ, Duke T, Rahman AE, Ahmed T, Arifeen SE, Clemens JD, et al. Feasibility and acceptability of bubble continuous positive airway pressure oxygen therapy for the treatment of childhood severe pneumonia and hypoxaemia in Bangladeshi children. Journal of Global Health. 2023; 13: 04040.

[2] Wu X, Lu W, Wang T, Xiao A, Guo X, Xu Y, et al. Optimization strategy for the early timing of bronchoalveolar lavage treatment for children with severe mycoplasma pneumoniae pneumonia. BMC Infectious Diseases. 2023; 23: 661.

[3] Luo XQ, Luo J, Wang CJ, Luo ZX, Tian DY, Xie XH. Clinical features of severe mycoplasma pneumoniae pneumonia with pulmonary complications in childhood: a retrospective study. Pediatric Pulmonology. 2023; 58: 2815–2822.

[4] Xu XH, Fan HF, Shi TT, Yang DY, Huang L, Zhang DW, et al. Analysis of mortality risk factors in children with severe adenovirus pneumonia: a single-center retrospective study. Pediatrics & Neonatology. 2023; 64: 280–287.

[5] Fan C, Fang B, Gao H, Li R, Su G, Mao Y, et al. Applications of mPCR testing reduced initial antibiotic use and duration of mechanical ventilation in virus-infected children with severe community-acquired pneumonia admitted to the PICU. World Journal of Pediatrics. 2022; 18: 449–452.

[6] Abeja CJ, Niyonzima V, Byagamy JP, Obua C. Antibiotic prescription rationality and associated in-patient treatment outcomes in children under-five with severe pneumonia at Bwizibwera health center IV, Mbarara District, South-Western Uganda. Pneumonia. 2022; 14: 3.

[7] Niu L, Xiao L, Zhang X, Liu X, Liu X, Huang X, et al. Comparative efficacy of Chinese herbal injections for treating severe pneumonia: a systematic review and Bayesian network meta-analysis of randomized controlled trials. Frontiers in Pharmacology. 2022; 12: 743486.

[8] Saad S, Ibrahim S, Moustafa S, Diab FEA. Calcitonin gene-related peptide and its correlation with prognosis in severe pneumonia among children below 6 years at PICU of Al Zahraa university hospital. Egyptian Journal of Immunology. 2023; 30: 111–120.

[9] Tran-Quang K, Nguyen-Thi-Dieu T, Tran-Do H, Pham-Hung V, Nguyen-Vu T, Tran-Xuan B, et al. Antibiotic resistance of Streptococcus pneumoniae in Vietnamese children with severe pneumonia: a cross-sectional study. Frontiers in Public Health. 2023; 11: 1110903.

[10] Wong JJM, Abbas Q, Dang H, Phan P, Guo L, Liu C, et al. 627: Epidemiology of severe pediatric pneumonia in Asia: a prospective multinational observational study. Critical Care Medicine. 2023; 51: 303.

[11] Amare RA, Fisseha G, Berhe A, Tirore LL. Incidence of recovery from severe pneumonia and its predictors among children 2–59 months admitted to pediatric ward of Ayder Comprehensive Specialized Hospital, Tigray, Ethiopia: a retrospective cohort study. Journal of Family Medicine and Primary Care. 2022; 11: 5285–5292.

[12] Dong J, Gao Z, Liu Y, Chen Y. Traditional Chinese medicine pattern classification and herbal medicine for COVID-19: a comparative study of data from different sources. World Journal of Traditional Chinese Medicine. 2023; 9: 81–93. (In Chinese)

[13] Wang L, Fan Y, Xu J, Deng H, Geng C, Jia B. The efficacy and safety of Tanreqing injection combined with western medicine for severe pneumonia: a protocol for systematic review and meta-analysis. Medicine. 2020; 99: e22010.

[14] Han X, Huang Y, Liu C, Liu Q, Wang S. The efficacy and safety of anti-humidification traditional Chinese medicine in the treatment of viral pneumonia: a meta-analysis. TMR Modern Herbal Medicine. 2023; 6: 4.

[15] Xie K, Guan SN, Jing H, Zhang CX, Wang HF. Analysis of outcome indicators in clinical trials on Chinese medicine as adjuvant therapy for severe pneumonia. China Journal of Chinese Materia Medica. 2022; 47: 5642–5653. (In Chinese)

[16] Xue M, Da C. The protective effect of Qingfei Huatan decoction on pulmonary function and its influence on the immunological function in children with severe pneumonia. American Journal of Translational Research. 2021; 13: 9404–9412.

[17] Huang P, Guo Y, Zhao J, Li B, Wu Y, Liu Q. “Efficacy and safety of the Qiguiyin formula in severe pneumonia: study protocol for a randomized, double-blind, placebo-controlled clinical trial”. Journal of Traditional Chinese Medicine. 2020; 40: 317–323.

[18] Lan Z, Liu Z, Luo X, Xi S, Mo L. The influence of integrated Chinese and western medicine treatment on the quality of life and laboratory indicators of patients with novel coronavirus pneumonia. Journal of Biosciences and Medicines. 2023; 11: 18–34. (In Chinese)

[19] An X, Shi C, Han Y, Li X, Dong L, Li Y, et al. The rational dose for MaXingShiGan decoction is crucial for its clinical effectiveness in treating bronchial pneumonia: three randomized, double-blind, dose-parallel controlled clinical studies. Frontiers in Pharmacology. 2023; 14: 1279519.

[20] Luo W, Liu Y, Zhang Q, Zhong H, Deng J. Effect of traditional Chinese medicine injections on severe pneumonia a protocol for systematic review and meta-analysis. Medicine. 2020; 99: e22012.

[21] Omori M, Saito Y, Miura Y, Tanaka T, Kashiwada T, Atsumi K, et al. Severe pneumonitis with alveolar hemorrhage associated with herbal medicines: a case report. Journal of Nippon Medical School. 2019; 86: 296–300.

[22] Cui Y, He W. Study on the law of TCM medication for for mild and medium-sized coronavirus pneumonia based on an ancient doctor case cloud platform. MEDS Chinese Medicine. 2023; 5: 1–9.

[23] Lee DYW, Li QY, Liu J, Efferth T. Traditional Chinese herbal medicine at the forefront battle against COVID-19: clinical experience and scientific basis. Phytomedicine. 2021; 80: 153337.

[24] Zhao Q, Zhao R, Geng Z, Bao L, Guo S, Wang Y, et al. Xuanfei Baidu granule alleviates coronavirus-induced pneumonia in low-temperature and high-humidity environments. Acupuncture and Herbal Medicine. 2023; 3: 200–206. (In Chinese)

[25] Xu Y, Bao L, Cao S, Pang B, Zhang J, Zhang Y, et al. Pharmacological effects and mechanism of Maxing Shigan decoction in the treatment of Pseudomonas aeruginosa pneumonia. Journal of Ethnopharmacology. 2024; 320: 117424.


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