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Original Research

Open Access

Efficacy observation of erythropoietin on sepsis complicated with acute respiratory distress syndrome

  • Ling Jia1,†
  • Xiang Xue1,†
  • Weixiao Zhang2
  • Jianqin Cai1
  • Jinghui Yang1,*,
  • Wei Zhao1,*,

1Department of Critical Care Medicine, SIR RUN RUN hospital of Nanjing Medical University, 211100 Nanjing, Jiangsu, China

2Department of Radiology, SIR RUN RUN hospital of Nanjing Medical University, 211100 Nanjing, Jiangsu, China

DOI: 10.22514/sv.2024.046 Vol.20,Issue 4,April 2024 pp.99-105

Submitted: 10 January 2024 Accepted: 18 March 2024

Published: 08 April 2024

*Corresponding Author(s): Jinghui Yang E-mail: Yangjinghui911@163.com
*Corresponding Author(s): Wei Zhao E-mail: zhaowei8051@163.com

† These authors contributed equally.

Abstract

This study is to evaluate the efficacy of erythropoietin in treating sepsis-associated acute respiratory distress syndrome (ARDS). One hundred patients with sepsis-related ARDS were randomized into the placebo group and Erythropoietin (EPO) group. Patients in the placebo group received saline as placebo on the standard therapy, while the EPO group received recombinant human erythropoietin injections on the standard therapy. It was found that the heart rate and mean arterial pressure did not differ significantly between days 7 and 14 after treatment initiation (p > 0.05). The partial pressure of oxygen (PaO2) and oxygenation index levels measured on days 7 and 14 were significantly higher than the placebo group and partial pressure of carbon dioxide (PaCO2) was significantly lower than the placebo group (p < 0.05). Lung capacity and functional residual capacity (and FRC) increased significantly in tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), and C-reactive protein (CRP) concentrations (p < 0.05). In the EPO group, the duration of mechanical ventilation was significantly shorter and the mortality rate was significantly reduced (Log-Rank test, χ2 = 4.651, p = 0.031). The results confirm that EPO significantly improves lung function and blood gas parameters, reduces serum levels of inflammatory markers, and reduces the risk of death in sepsis-induced ARDS patients, highlighting the potential therapeutic role of EPO in the management of this disease.


Keywords

Erythropoietin; Sepsis; Acute respiratory distress syndrome; Efficacy


Cite and Share

Ling Jia,Xiang Xue,Weixiao Zhang,Jianqin Cai,Jinghui Yang,Wei Zhao. Efficacy observation of erythropoietin on sepsis complicated with acute respiratory distress syndrome. Signa Vitae. 2024. 20(4);99-105.

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