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Application of opioid-free general anesthesia in laparoscopy: a meta-analysis of randomized controlled studies

  • Mei-hui Gao1,*,
  • Jin Meng1
  • Xu-ming Hu1
  • Jie Liu1

1Department of Anesthesiology, Sir Run Run Shaw Hospital Affiliated to Zhejiang University, 310016 Hangzhou, Zhejiang, China

DOI: 10.22514/sv.2024.050

Submitted: 22 August 2023 Accepted: 13 October 2023

Online publish date: 26 April 2024

*Corresponding Author(s): Mei-hui Gao E-mail: L220397@zju.edu.cn

Abstract

Applying opioid-free general anesthesia (OFGA) in laparoscopy was controversial. A systematic review and meta-analysis were conducted to investigate the efficacy and safety of employing OFGA in laparoscopy. Relevant clinical trials to include in this systematic review and meta-analysis were scrutinized through electronic databases such as Embase, PubMed, Cochrane Library and Web of Science. The quality of selected randomized controlled trials (RCTs) was assessed by Cochrane Collaboration’s bias risk assessment tool. The meta-analysis was conducted on Review Manager 5.3. The quality of evidence was assessed in accordance with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework. The analysis in this study included 14 RCTs involving 1042 patients. No notable variation examined in 24-hour postoperative pain score between the opioid-based and OFGA groups (mean difference = −0.43, 95% confidence interval (−1.08, 0.22); p = 0.19). However, OFGA application reduced the postoperative analgesic needs and the incidence of postoperative nausea and vomiting. The meta-analysis and systematic review findings indicated that OFGA could be effectively and safely used in laparoscopy.


Keywords

Opioid-free general anesthesia; Laparoscopy; Meta-analysis


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Mei-hui Gao,Jin Meng,Xu-ming Hu,Jie Liu. Application of opioid-free general anesthesia in laparoscopy: a meta-analysis of randomized controlled studies. Signa Vitae. 2024.doi:10.22514/sv.2024.050.

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