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Original Research

Open Access

The role of Asprosin in the diagnosis of diabetic and non-diabetic patients with sepsis

  • Semra Aytürk Salt1,*,
  • Nurettin Aydoğdu2
  • Ömer Salt3
  • Nihayet Fırat4
  • Necdet Süt5

1Department of Endocrinology and Metabolic Diseases, Kayseri City Hospital, 38080 Kayseri, Turkey

2Department of Medical Physiology, İnönü University, 44000 Malatya, Turkey

3Department of Emergency Medicine, Kayseri City Hospital, 38080 Kayseri, Turkey

4Department of Medical Physiology, Trakya University Medical Faculty, 22100 Edirne, Turkey

5Department of Biostatistics and Medical Information, Trakya University Medical Faculty, 22100 Edirne, Turkey

DOI: 10.22514/sv.2024.056 Vol.20,Issue 5,May 2024 pp.40-45

Submitted: 26 October 2023 Accepted: 22 December 2023

Published: 08 May 2024

*Corresponding Author(s): Semra Aytürk Salt E-mail: semra.ayturksalt@saglik.gov.tr

Abstract

Sepsis is among the major causes of mortality in the world due to its delayed diagnosis and inadequate treatment. Due to the high morbidity and mortality rates, a widely accepted biomarker is required for its diagnosis. Present study aimed to evaluate the serum asprosin levels in septic patients and determine its potential use as a biomarker for its diagnosis. A prospective cohort study was performed with total 81 participants. These were divided in two groups, i.e., 54 septic patients and 27 healthy volunteers (control group). Among 54 septic participants, half (27) were diabetic, and half (27) were nondiabetic. Blood samples (3 mL) were collected from the control group and the patients who were diagnosed with sepsis and transferred to serum seperator tube. Samples were fractioned and stored at −80 ◦C for further evaluation. These samples were used for the measurement of serum asprosin levels. Demographic characteristics and laboratory data of the patients were recorded in the study form prepared previously. The serum asprosin levels in the control group were 4.1 ± 1.4 ng/mL, 32.8 ± 7 ng/mL in the non-diabetic septic patients and 90.7 ± 5.5 ng/mL in diabetic septic patients. The asprosin level in the non-diabetic group were higher as compared to the control group (p: 0.012), and it was statistically significantly higher in the diabetic group compared to the non-diabetic septic and control groups (both: p < 0.001). Serum asprosin levels were significantly higher in patients with sepsis specially having diabetes. Serum asprosin levels may be beneficial for the diagnosis of sepsis especially in diabetic patients along with the other laboratory parameters white blood cells (WBC), C-reactive protein (CRP), sequential organ failure assessment score (SOFA score) and fewer.


Keywords

Asprosin; Diabetes mellitus; Diagnosis; Sepsis


Cite and Share

Semra Aytürk Salt,Nurettin Aydoğdu,Ömer Salt,Nihayet Fırat,Necdet Süt. The role of Asprosin in the diagnosis of diabetic and non-diabetic patients with sepsis. Signa Vitae. 2024. 20(5);40-45.

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