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Original Research

Open Access

Effects of immediate and delayed infusion of residual physical blood on coagulation function, intraoperative bleeding, and hemostasis time in aortic dissection surgery under cardiopulmonary bypass

  • Xiaoyan Liang1
  • Hua Zhang2
  • Xiangyu Luo1
  • Li Zhang1
  • Jingjing Guo1
  • Jun Zhang1,*,

1Department of Thoracic Cardiovascular Surgery, Taihe Hospital Affiliated Hospital of Hubei University of Medicine, 442000 Shiyan, Hubei, China

2Department of Breast and Thyroid Surgery, Taihe Hospital Affiliated Hospital of Hubei University of Medicine, 442000 Shiyan, Hubei, China

DOI: 10.22514/sv.2024.062 Vol.20,Issue 5,May 2024 pp.101-106

Submitted: 20 December 2023 Accepted: 10 April 2024

Published: 08 May 2024

*Corresponding Author(s): Jun Zhang E-mail: junzh711@163.com

Abstract

This study aims to assess the differences in coagulation function, intraoperative bleeding and hemostasis time resulting from immediate versus delayed infusion of residual physical blood in patients undergoing cardiopulmonary bypass for aortic dissection. From January 2018 to January 2021, the data of 122 patients diagnosed with acute Stanford type A aortic dissection and treated at Taihe Hospital Affiliated Hospital of Hubei University of Medicine were retrieved and assessed. They were then divided into two groups according to different treatments: a research group and a control group. The research group received a delayed infusion of residual physical blood intraoperatively, while the control group underwent immediate infusion. Various indicators of coagulation, encompassing activated partial thromboplastin time, prothrombin time, thrombin time, and fibrinogen levels, along with hemoglobin levels, utilization of blood products such as red cell suspension, plasma, platelets, and cryoprecipitate, as well as the volume of bleeding, total fluid intake and output, and durations of hemostasis, surgery, and anesthesia, were compared between the two groups. After surgery, coagulation and hemoglobin levels, which were initially similar between the two groups, were found to be significantly improved, with the research group showing superior outcomes (p < 0.05). Additionally, patients in the research group required significantly fewer blood products, experienced reduced bleeding and total body fluid exchange and had markedly shorter durations of hemostasis, surgery and anesthesia compared to those in the control group (p < 0.05). Pre-infusion adjustment of coagulation function before residual whole blood infusion effectively improves coagulation, reduces bleeding and fluid imbalance, and shortens hemostasis time during aortic dissection surgery with cardiopulmonary bypass. This approach not only reduces transfusion-related risks and improves postoperative recovery but also plays a significant role in optimizing blood management.


Keywords

Cardiopulmonary bypass; Aortic dissection surgery; Immediate infusion; Delayed infusion; Intraoperative hemorrhage; Hemostasis time


Cite and Share

Xiaoyan Liang,Hua Zhang,Xiangyu Luo,Li Zhang,Jingjing Guo,Jun Zhang. Effects of immediate and delayed infusion of residual physical blood on coagulation function, intraoperative bleeding, and hemostasis time in aortic dissection surgery under cardiopulmonary bypass. Signa Vitae. 2024. 20(5);101-106.

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