Article Data

  • Views 267
  • Dowloads 120

Original Research

Open Access

The impact of using next-generation pulse oximetry on the outcomes of preterm babies admitted to the NICU: a randomized controlled trial

  • Jaber Alfaifi1,2,*,

1Child Health department, College of Medicine, University of Bisha, 61922 Bisha, Saudi Arabia

2Maternity and Children’s Hospital, Ministry of Health, 67713 Bisha, Saudi Arabia

DOI: 10.22514/sv.2024.078

Submitted: 22 January 2024 Accepted: 17 April 2024

Online publish date: 03 July 2024

*Corresponding Author(s): Jaber Alfaifi E-mail:


The purpose of this randomized controlled trial was to investigate the influence of state-of-the-art pulse oximetry technology on the health outcomes of preterm newborns in a Neonatal Intensive Care Unit (NICU). We included preterm infants born between 24 and 36 weeks of gestation in our analysis, excluding those with significant congenital anomalies, lung malformations, congenital heart defects, or early neonatal mortality. Our study involved 52 newborns, divided into two groups: one cohort was monitored using conventional oximetry, while the other was monitored with advanced pulse oximetry technology. The baseline characteristics of both cohorts, such as gender, gestational age, birth weight, prenatal care received, and infection risk, were comparable. Both groups received standardized care based on established clinical guidelines, including feeding assistance, infection prevention techniques, thermoregulation, respiratory distress management, and parental involvement through kangaroo care. We assessed the outcomes for common neonatal issues, such as chronic lung disease, sepsis, intraventricular hemorrhage, patent ductus arteriosus, and air leak syndromes. Our results indicate that there were no statistically significant differences in the primary outcomes between the two groups, suggesting that the randomization process was effective in creating balanced comparison groups. We utilized independent samples t-tests and chi-square tests as part of our statistical framework, with a p-value of less than 0.05 indicating statistical significance. Overall, our findings suggest that the implementation of next-generation pulse oximetry equipment in the NICU for monitoring preterm infants does not significantly affect clinical outcomes compared to conventional monitoring techniques. Further research is necessary to fully evaluate the benefits and feasibility of incorporating cutting-edge oximetry technologies into newborn care procedures.


New generation oximetry; Preterm babies; Neonatal intensive care unit; Randomized controlled trial

Cite and Share

Jaber Alfaifi. The impact of using next-generation pulse oximetry on the outcomes of preterm babies admitted to the NICU: a randomized controlled trial. Signa Vitae. 2024.doi:10.22514/sv.2024.078.


[1] Alhassen Z, Vali P, Guglani L, Lakshminrusimha S, Ryan RM. Recent advances in pathophysiology and management of transient tachypnea of newborn. Journal of Perinatology. 2021; 41: 6–16.

[2] Sola A, Golombek SG, Montes Bueno MT, Lemus-Varela L, Zuluaga C, Domínguez F, et al. Safe oxygen saturation targeting and monitoring in preterm infants: can we avoid hypoxia and hyperoxia? Acta Paediatrica. 2014; 103: 1009–1018.

[3] Zambrano SL, Garcés MU, Mazon JH, Carrillo FR, Morales CL. Factors associated with severe neonatal respiratory distress syndrome. Ecuadorian Journal of Pediatrics. 2022; 23: 93–100.

[4] Srivatsa B, Malcolm K, Clark RH, Kupke KG. Effect of a novel oxygen saturation targeting strategy on mortality, retinopathy of prematurity, and bronchopulmonary dysplasia in neonates born extremely preterm. The Journal of Pediatrics. 2021; 234: 33–37.e3.

[5] Dormishian A, Schott A, Aguilar AC, Bancalari E, Claure N. Pulse oximetry reliability for detection of hypoxemia under motion in extremely premature infants. Pediatric Research. 2023; 93: 118–124.

[6] Horakova L, Roubik K. Pulse oximeter performance during rapid desaturation. Sensors. 2022; 22: 4236.

[7] Cao G, Liu J, Liu M. Global, regional, and national incidence and mortality of neonatal preterm birth, 1990–2019. JAMA Pediatrics. 2022; 176: 787–796.

[8] Ali SKM, Mohammed N, Qureshi N, Gupta S. Oxygen therapy in preterm infants: recommendations for practice. Paediatrics and Child Health. 2021; 31: 1–6.

[9] Falsaperla R, Giacchi V, Saporito MAN, Pavone P, Puglisi F, Ruggieri M. Pulse oximetry saturation (Spo2) monitoring in the neonatal intensive care unit (NICU): the challenge for providers: a systematic review. Advances in Neonatal Care. 2022; 22: 231–238.

[10] Poorzargar K, Pham C, Ariaratnam J, Lee K, Parotto M, Englesakis M, et al. Accuracy of pulse oximeters in measuring oxygen saturation in patients with poor peripheral perfusion: a systematic review. Journal of Clinical Monitoring and Computing. 2022; 36: 961–973.

[11] Vesoulis Z, Tims A, Lodhi H, Lalos N, Whitehead H. Racial discrepancy in pulse oximeter accuracy in preterm infants. Journal of Perinatology. 2022; 42: 79–85.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.3 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time