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The renal effects of amino acids infusion

  • Rosario Losiggio1
  • Martina Baiardo Redaelli1
  • Alessandro Pruna1
  • Giovanni Landoni1,2,*,
  • Rinaldo Bellomo3,4,5,6,7

1Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

2School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy

3Department of Critical Care, The University of Melbourne, 3010 Melbourne, VIC, Australia

4Australian and New Zealand Intensive Care Research Centre, Monash University, 3004 Melbourne, VIC, Australia

5Data Analytics Research and Evaluation Centre, Austin Hospital, 3084 Melbourne, VIC, Australia

6Department of Intensive Care, Austin Hospital, 3084 Melbourne, VIC, Australia

7Department of Intensive Care, Royal Melbourne Hospital, 3050 Melbourne, VIC, Australia

DOI: 10.22514/sv.2024.079 Vol.20,Issue 7,July 2024 pp.1-4

Submitted: 08 June 2024 Accepted: 26 June 2024

Published: 08 July 2024

*Corresponding Author(s): Giovanni Landoni E-mail:


Amino acids; Renal protection; Acute kidney injury; Renal failure

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Rosario Losiggio,Martina Baiardo Redaelli,Alessandro Pruna,Giovanni Landoni,Rinaldo Bellomo. The renal effects of amino acids infusion. Signa Vitae. 2024. 20(7);1-4.


[1] Ronco C, Bellomo R, Kellum JA. Acute kidney injury. The Lancet. 2019; 394: 1949–1964.

[2] Al-Jaghbeer M, Dealmeida D, Bilderback A, Ambrosino R, Kellum JA. Clinical decision support for in-hospital AKI. Journal of the American Society of Nephrology. 2018; 29: 654–660.

[3] Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Colman R, Cruz DN, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Medicine. 2015; 41: 1411–1423.

[4] Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. Journal of the American Society of Nephrology. 2015; 16: 3365–3370.

[5] Fiore PM, Richter CU, Arzeno G, Arrigg CA, Shingleton BJ, Bellows AR, et al. The effect of anterior chamber depth on endothelial cell count after filtration surgery. Archives of Ophthalmology. 1989; 107: 1609–1611.

[6] Husain-Syed F, Ferrari F, Sharma A, Danesi TH, Bezerra P, Lopez-Giacoman S, et al. Preoperative renal functional reserve predicts risk of acute kidney injury after cardiac operation. The Annals of Thoracic Surgery. 2018; 105: 1094–1101.

[7] Ronco C, Ricci Z, De Backer D, Kellum JA, Taccone FS, Joannidis M, et al. Renal replacement therapy in acute kidney injury: controversy and consensus. Critical Care. 2015; 19: 146.

[8] Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury. Kidney International. 2012; 2: 1–138.

[9] Brenner BM, Meyer TW, Hostetter TH. Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. New England Journal of Medicine. 1982; 307: 652–659.

[10] Abel RM, Beck CH, Abbott WM, Ryan JA, Barnett GO, Fischer JE. Improved survival from acute renal failure after treatment with intravenous essential l-amino acids and glucose. New England Journal of Medicine. 1973; 288: 695–699.

[11] Jufar AH, Evans RG, May CN, Hood SG, Betrie AH, Trask-Marino A, et al. The effects of recruitment of renal functional reserve on renal cortical and medullary oxygenation in non-anesthetized sheep. Acta Physiologica. 2023; 237: e13919.

[12] Doig GS, Simpson F, Bellomo R, Heighes PT, Sweetman EA, Chesher D, et al. Intravenous amino acid therapy for kidney function in critically ill patients: a randomized controlled trial. Intensive Care Medicine. 2015; 41: 1197–1208.

[13] Pu H, Doig GS, Heighes PT, Allingstrup MJ, Wang A, Brereton J, et al. Intravenous amino acid therapy for kidney protection in cardiac surgery patients: a pilot randomized controlled trial. The Journal of Thoracic and Cardiovascular Surgery. 2019; 157: 2356–2366.

[14] Zhu R, Allingstrup MJ, Perner A, Doig GS; Nephro-Protective Trial Investigators Group. The effect of IV amino acid supplementation on mortality in ICU patients may be dependent on kidney function: post hoc subgroup analyses of a multicenter randomized trial. Critical Care Medicine. 2018; 46: 1293–1301.

[15] Landoni G, Brambillasca C, Baiardo Redaelli M, Bradić N, Ti LK, Povšić-Čevra Z, et al. Intravenous amino acid therapy for kidney protection in cardiac surgery a protocol for a multi-centre randomized blinded placebo controlled clinical trial. The PROTECTION trial. Contemporary Clinical Trials. 2022; 121: 106898.

[16] Landoni G, Monaco F, Ti LK, Baiardo Redaelli M, Bradic N, Comis M, et al. A randomized trial of intravenous amino acids for kidney protection. To be published in New England Journal of Medicine. 2024. [Preprint].

[17] Thomson SC, Vallon V, Blantz RC. Kidney function in early diabetes: the tubular hypothesis of glomerular filtration. American Journal of Physiology. Renal physiology. 2004; 286: F8–F15.

[18] Stevens LA, Coresh J, Greene T, Levey AS. Assessing kidney function—measured and estimated glomerular filtration rate. New England Journal of Medicine. 2006; 354: 2473–2483.

[19] Bjornstad P, Karger AB, Maahs DM. Measured GFR in routine clinical practice-the promise of dried blood spots. Advances in Chronic Kidney Disease. 2018; 25: 76–83.

[20] Bosch JP, Saccaggi A, Lauer A, Ronco C, Belledonne M, Glabman S. Renal functional reserve in humans. Effect of protein intake on glomerular filtration rate. The American Journal of Medicine. 1983; 75: 943–950.

[21] Jufar AH, Lankadeva YR, May CN, Cochrane AD, Bellomo R, Evans RG. Renal functional reserve: from physiological phenomenon to clinical biomarker and beyond. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2020; 319: R690–R702.

[22] Ronco C, Bellomo R, Kellum J. Understanding renal functional reserve. Intensive Care Medicine. 2017; 43: 917–920.

[23] Brezis M, Silva P, Epstein FH. Amino acids induce renal vasodilatation in isolated perfused kidney: coupling to oxidative metabolism. The American Journal of Physiology. 1984; 247: H999–H1004.

[24] Woods LL, Mizelle HL, Montani JP, Hall JE. Mechanisms controlling renal hemodynamics and electrolyte excretion during amino acids. The American Journal of Physiology. 1986; 251: F303–F312.

[25] Seney FD Jr, Persson EG, Wright FS. Modification of tubuloglomerular feedback signal by dietary protein. The American Journal of Physiology. 1987; 252: F83–F90.

[26] Premen AJ, Dobbins DE. Effects of amino acid isomers on canine renal hemodynamics. The American Journal of Physiology. 1990; 258: F799–F804.

[27] Tolins JP, Shultz PJ, Westberg G, Raij L. Renal hemodynamic effects of dietary protein in the rat: role of nitric oxide. The Journal of Laboratory and Clinical Medicine. 1995; 125: 228–236.

[28] Yao B, Xu J, Qi Z, Harris RC, Zhang MZ. Role of renal cortical cyclooxygenase-2 expression in hyperfiltration in rats with high-protein intake. American Journal of Physiology. Renal Physiology. 2006; 291: F368–F374.

[29] DeSanto NG, Coppola S, Anastasio P, Coscarella G, Capasso G, Castellino P, et al. Pancreatectomy abolishes the renal hemodynamic response to a meat meal in man. Nephron. 1990; 55: 85–86.

[30] Premen AJ, Powell DA, Carroll RG, Dobbins DE. Renal vascular response to amino acids: effect of pancreatectomy. The American Journal of Physiology. 1990; 258: F1154–F1163.

[31] Friedlander G, Blanchet-Benqué F, Nitenberg A, Laborie C, Assan R, Amiel C. Glucagon secretion is essential for aminoacid-induced hyperfiltration in man. Nephrology, Dialysis, Transplantation. 1990; 5: 110–117.

[32] Schrijvers BF, Rasch R, Tilton RG, Flyvbjerg A. High protein-induced glomerular hypertrophy is vascular endothelial growth factor-dependent. Kidney International. 2002; 61: 1600–1604.

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