Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Artesunate inhibits ROS production and ameliorates mitochondrial damage through the SIRT1/FOXO3a/MnSOD pathway to alleviate heart failure
1Department of Cardiology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, 430074 Wuhan, Hubei, China
2Departement of Gynecological Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430079 Wuhan, Hubei, China
DOI: 10.22514/sv.2024.116 Vol.20,Issue 9,September 2024 pp.103-109
Submitted: 31 May 2024 Accepted: 09 July 2024
Published: 08 September 2024
*Corresponding Author(s): Peng Hu E-mail: hup0871@163.com
Heart failure (HF) is a complex and multifactorial disease responsible for over 17.3 million deaths annually, primarily mediated by oxidative stress-induced mitochondrial dysfunction. Artesunate (AS), an artemisinin derivative, possesses anti-inflammatory and antioxidative properties and is used to enhance mitochondrial function and reduce reactive oxygen species (ROS) generation. However, its specific effects and mechanisms in HF remain poorly understood. In this study, we investigated the impact of AS on Doxorubicin hydrochloride (Dox)-induced injury in H9C2 cardiomyocytes. The results showed that AS promoted cell viability, decreased ROS production and mitigated mitochondrial damage in Dox-exposed H9C2 cells. Importantly, AS also modulated the Silent information regulator 1 (SIRT1)/Forkhead box O3a (FOXO3a)/Manganese superoxide dismutase (MnSOD) pathway, indicating its potential therapeutic utility in HF by inhibiting ROS production and preserving mitochondrial function in doxorubicin-treated H9C2 cardiomyocytes.
Heart failure (HF); Artesunate (AS); Dox; Mitochondrial damage; SIRT1/FOXO3a/MnSOD pathway
Yaping Li,Peng Hu. Artesunate inhibits ROS production and ameliorates mitochondrial damage through the SIRT1/FOXO3a/MnSOD pathway to alleviate heart failure. Signa Vitae. 2024. 20(9);103-109.
[1] Gil-Cayuela C, López A, Martínez-Dolz L, González-Juanatey JR, Lago F, Roselló-Lletí E, et al. The altered expression of autophagy-related genes participates in heart failure: NRBP2 and CALCOCO2 are associated with left ventricular dysfunction parameters in human dilated cardiomyopathy. PLOS ONE. 2019; 14: e0215818.
[2] Wan J, Zhang Z, Wu C, Tian S, Zang Y, Jin G, et al. Astragaloside IV derivative HHQ16 ameliorates infarction-induced hypertrophy and heart failure through degradation of lncRNA4012/9456. Signal Transduction and Targeted Therapy. 2023; 8: 414.
[3] Nedkoff L, Weber C. Heart failure: not just a disease of the elderly. Heart. 2022; 108: 249–250.
[4] Chen J, Chen S, Zhang B, Liu J. SIRT3 as a potential therapeutic target for heart failure. Pharmacological Research. 2021; 165: 105432.
[5] Li L, Chen J, Zhou Y, Zhang J, Chen L. Artesunate alleviates diabetic retinopathy by activating autophagy via the regulation of AMPK/SIRT1 pathway. Archives of Physiology and Biochemistry. 2023; 129: 943–950.
[6] Ji T, Chen M, Liu Y, Jiang H, Li N, He X. Artesunate alleviates intestinal ischemia/reperfusion induced acute lung injury via up-regulating AKT and HO-1 signal pathway in mice. International Immunopharmacology. 2023; 122: 110571.
[7] Chen Y, Wu J, Zhu J, Yang G, Tian J, Zhao Y, et al. Artesunate provides neuroprotection against cerebral ischemia-reperfusion injury via the TLR-4/NF-κB pathway in rats. Biological & Pharmaceutical Bulletin. 2021; 44: 350–356.
[8] Gu L, Zhang J, Liu D, Chen J, Liu S, Peng Q, et al. Development of artesunate intelligent prodrug liposomes based on mitochondrial targeting strategy. Journal of Nanobiotechnology. 2022; 20: 376.
[9] Rajkhowa B, Mehan S, Sethi P, Prajapati A, Suri M, Kumar S, et al. Activating SIRT-1 signalling with the mitochondrial-CoQ10 activator solanesol improves neurobehavioral and neurochemical defects in ouabain-induced experimental model of bipolar disorder. Pharmaceuticals. 2022; 15: 959.
[10] Jin B, Gao Y, Fu Y, Zhang S, Zhang K, Su Y. Electroacupuncture improves cognitive function in a rat model of mild traumatic brain injury by regulating the SIRT-1/PGC-1α/mitochondrial pathway. Chinese Medical Journal. 2024; 137: 711–719.
[11] Bošković M, Živković M, Korićanac G, Stanišić J, Zec M, Krga I, et al. Walnut supplementation restores the SIRT1-FoxO3a-MnSOD/Catalase axis in the heart, promotes an anti-inflammatory fatty acid profile in plasma, and lowers blood pressure on fructose-rich diet. Oxidative Medicine and Cellular Longevity. 2021; 2021: 5543025.
[12] Halade GV, Lee DH. Inflammation and resolution signaling in cardiac repair and heart failure. EBioMedicine. 2022; 79: 103992.
[13] Abouleisa RRE, Salama ABM, Ou Q, Tang X, Solanki M, Guo Y, et al. Transient cell cycle induction in cardiomyocytes to treat subacute ischemic heart failure. Circulation. 2022; 145: 1339–1355.
[14] Gallo G, Rubattu S, Volpe M. Mitochondrial dysfunction in heart failure: from pathophysiological mechanisms to therapeutic opportunities. International Journal of Molecular Sciences. 2024; 25: 2667.
[15] Peoples JN, Saraf A, Ghazal N, Pham TT, Kwong JQ. Mitochondrial dysfunction and oxidative stress in heart disease. Experimental & Molecular Medicine. 2019; 51: 1–13.
[16] Keil U, Scherping I, Hauptmann S, Schuessel K, Eckert A, Müller WE. Piracetam improves mitochondrial dysfunction following oxidative stress. British Journal of Pharmacology. 2006; 147: 199–208.
[17] Ngasala B, Bushukatale S, Chiduo M, Makene T, Mkony L, Mohamed A, et al. Efficacy of artesunate-amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in mainland Tanzania. Malaria Journal. 2024; 23: 90.
[18] ZhaoGZ, Jing JM. HOMER1A restores sevoflurane-induced cognitive dysfunction by regulating microglia’s activation through activating the AMPK/TXNIP axis. Signa Vitae. 2023; 19: 202–212.
[19] Li Y, Shen G, Yu C, Li G, Shen J, Gong J, et al. Angiotensin II induces mitochondrial oxidative stress and mtDNA damage in osteoblasts by inhibiting SIRT1-FoxO3a-MnSOD pathway. Biochemical and Biophysical Research Communications. 2014; 455: 113–118.
[20] Ni Y, Deng J, Liu X, Li Q, Zhang J, Bai H, et al. Echinacoside reverses myocardial remodeling and improves heart function via regulating SIRT1/FOXO3a/MnSOD axis in HF rats induced by isoproterenol. Journal of Cellular and Molecular Medicine. 2021; 25: 203–216.
Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.
Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.
Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.
Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.
Scopus: CiteScore 1.3 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.
Top