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The arc of a life in critical care research—in memory of Professor Rinaldo Bellomo (1956–2025)

  • Giovanni Landoni1,2,*,
  • Martina Baiardo Redaelli3,4

1Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

2School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy

3Department of Biotechnologies and Life Sciences, University of Insubria, 21100 Varese, Italy

4General and Neurosurgical Intensive Care Units, Hospital di Circolo and Macchi Foundation, ASST Sette Laghi, 21100 Varese, Italy

DOI: 10.22514/sv.2025.091

Submitted: 29 May 2025 Accepted: 04 June 2025

Online publish date: 17 June 2025

*Corresponding Author(s): Giovanni Landoni E-mail: landoni.giovanni@hsr.it

PDF (2.45 MB) Supplementary material View Full-text

Keywords

Critical care; Randomized controlled trial; Research; Evidence based medicine


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Giovanni Landoni,Martina Baiardo Redaelli. The arc of a life in critical care research—in memory of Professor Rinaldo Bellomo (1956–2025). Signa Vitae. 2025.doi:10.22514/sv.2025.091.

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https://www.signavitae.com/articles/10.22514/sv.2025.091

References

[1] Ronco C, Bellomo R. Critical care nephrology: the time has come. Nephrology Dialysis Transplantation. 1998; 13: 264–267.

[2] Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P; Acute Dialysis Quality Initiative workgroup. Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) group. Critical Care. 2004; 8: R204–R212.

[3] NICE-SUGAR Study Investigators; Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, et al. Intensive versus conventional glucose control in critically ill patients. The New England Journal of Medicine. 2009; 360: 1283–1297.

[4] Finfer S, Micallef S, Hammond N, Navarra L, Bellomo R, Billot L, et al. Balanced multielectrolyte solution versus saline in critically ill adults. The New England Journal of Medicine. 2022; 386: 815–826.

[5] Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. The New England Journal of Medicine. 2012; 367: 1901–1911.

[6] Khanna A, English SW, Wang XS, Ham K, Tumlin J, Szerlip H, et al. Angiotensin II for the treatment of vasodilatory shock. The New England Journal of Medicine. 2017; 377: 419–430.

[7] Bellomo R, Bagshaw S. Evidence-based medicine: classifying the evidence from clinical trials—the need to consider other dimensions. Critical Care. 2006; 10: 232.

[8] Landoni G, Monaco G, Ti LK, Baiardo Redaelli M, Bradic N, Comis M, et al. A randomized trial of intravenous amino acids for kidney protection. The New England Journal of Medicine. 2024; 391: 687–698.

[9] See EJ, Clapham C, Liu J, Khasin M, Liskaser G, Chan JW, et al. A pilot study of angiotensin II as primary vasopressor in critically ill adults with vasodilatory hypotension: the ARAMIS study. Shock. 2023; 59: 691–696.

[10] Coulson TG, Paul E, Miles LF, Pilcher D, Marasco SF, Frei D, et al. A Prospective double-blind, randomised controlled trial comparing angiotensin II to norepinephrine to reduce length of hospital stay in cardiac surgery patients (the PORTHOS study protocol). BMJ Open. 2025; 15: e095099.

[11] Serpa Neto A, Young P. In memory of professor Rinaldo Bellomo: a giant of intensive care medicine. Critical Care and Resuscitation. 2025; 27: 100110.


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