The arc of a life in critical care research—in memory of Professor Rinaldo Bellomo (1956–2025)

Critical care; Randomized controlled trial; Research; Evidence based medicine

[1] Ronco C, Bellomo R. Critical care nephrology: the time has come. Nephrology Dialysis Transplantation. 1998; 13: 264–267.

[2] Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P; Acute Dialysis Quality Initiative workgroup. Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) group. Critical Care. 2004; 8: R204–R212.

[3] NICE-SUGAR Study Investigators; Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, et al. Intensive versus conventional glucose control in critically ill patients. The New England Journal of Medicine. 2009; 360: 1283–1297.

[4] Finfer S, Micallef S, Hammond N, Navarra L, Bellomo R, Billot L, et al. Balanced multielectrolyte solution versus saline in critically ill adults. The New England Journal of Medicine. 2022; 386: 815–826.

[5] Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. The New England Journal of Medicine. 2012; 367: 1901–1911.

[6] Khanna A, English SW, Wang XS, Ham K, Tumlin J, Szerlip H, et al. Angiotensin II for the treatment of vasodilatory shock. The New England Journal of Medicine. 2017; 377: 419–430.

[7] Bellomo R, Bagshaw S. Evidence-based medicine: classifying the evidence from clinical trials—the need to consider other dimensions. Critical Care. 2006; 10: 232.

[8] Landoni G, Monaco G, Ti LK, Baiardo Redaelli M, Bradic N, Comis M, et al. A randomized trial of intravenous amino acids for kidney protection. The New England Journal of Medicine. 2024; 391: 687–698.

[9] See EJ, Clapham C, Liu J, Khasin M, Liskaser G, Chan JW, et al. A pilot study of angiotensin II as primary vasopressor in critically ill adults with vasodilatory hypotension: the ARAMIS study. Shock. 2023; 59: 691–696.

[10] Coulson TG, Paul E, Miles LF, Pilcher D, Marasco SF, Frei D, et al. A Prospective double-blind, randomised controlled trial comparing angiotensin II to norepinephrine to reduce length of hospital stay in cardiac surgery patients (the PORTHOS study protocol). BMJ Open. 2025; 15: e095099.

[11] Serpa Neto A, Young P. In memory of professor Rinaldo Bellomo: a giant of intensive care medicine. Critical Care and Resuscitation. 2025; 27: 100110.