Article Data

  • Views 211
  • Dowloads 135

Reviews

Open Access

Herbal poisoning cases in Turkey: a narrative review

  • Esen Sezen Karaoglan1,*,

1Department of Pharmaceutical Botany, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey

DOI: 10.22514/sv.2025.095 Vol.21,Issue 7,July 2025 pp.43-50

Submitted: 07 October 2024 Accepted: 16 December 2024

Published: 08 July 2025

*Corresponding Author(s): Esen Sezen Karaoglan E-mail: esen.karaoglan@atauni.edu.tr

Abstract

For centuries, humans have harnessed the diverse benefits of plants for a variety of purposes, including food, spices, medicinal remedies and home decoration. While there are thousands of plant species on Earth, some are toxic and instances of poisoning from the consumption of these toxic plants are documented in the literature. Toxic effects are often attributed to compounds such as alkaloids, anthraquinones, saponins, oxalic acid and cardioactive and cyanogenic compounds. In this research, some cases of herbal poisoning in Turkey were examined. It was observed that plants such as Rhododendron ponticum, Rhododendron luteum, Atropa belladonna, Conium maculatum, Ecballium elaterium, Nicotiana rustica, Dieffenbachia species Amanita phalloides, and herbal products such as Apple oil and Apricot seeds, are contributors to poisoning in Turkey. These cases of poisoning were observed in all age groups. Ornamental plants at home can pose a poisoning risk to children. While some poisonings result in mild symptoms, others can be life-threatening, and treatment typically focuses on alleviating symptoms and administering antidotes. Such poisonings may occur accidentally, carelessly or consciously. It is, therefore, necessary to exercise caution with poisonous plants and herbal products, and raise public awareness about their risk. Emergency medical personnel should have basic knowledge about plant poisonings, as recognizing the poisonous agent and providing prompt treatment can be life-saving in these situations.


Keywords

Herbal poisoning; Turkey; Treatment methods


Cite and Share

Esen Sezen Karaoglan. Herbal poisoning cases in Turkey: a narrative review. Signa Vitae. 2025. 21(7);43-50.

References

[1] Tuncok Y, Kalyoncı I. General approach to acute poisoning; Diagnostic and Therapeutic Guidelines for Primary Care. 1st edn. Publications of the Ministry of Health of the Republic of Turkey: Turkey. 2007.

[2] Ministry of Health of the Republic of Turkey. National poison consulting center (UZEM) reports 2014–2020. 2021. Available at: https://hsgm.saglik.gov.tr/tr/yayinlarimiz.html (Accessed: 03 March 2024).

[3] Petersen DD. Common plant toxicology: a comparison of national and southwest Ohio data trends on plant poisonings in the 21st century. Toxicology and Applied Pharmacology. 2011; 254: 148–153.

[4] Çıkrıklar Hİ, Aslan Ş. Plants poisoning. Turkey Clinics Journal of Emergency Medicine. 2018; 4: 113–119. (In Turkish)

[5] Karaca O. Antidotes. Aksaray University Journal of Medical Sciences. 2020; 1: 1–8. (In Turkish)

[6] Kafadar H. Health and science 2024 current medicine II. 1st edn. Efe Academy Publications: Turkey. 2024.

[7] Ornillo C, Harbord N. Fundaments of toxicology-approach to the poisoned patient. Advances in Chronic Kidney Disease. 2020; 27: 5–10.

[8] Ijaz MU, Ehsan N, Imran M, Yousaf S. Zoology: advancements and research Trends. 1st edn. Fahum Sci: Pakistan. 2024.

[9] Osmanlıoğlu Dağ ŞR, Gençler Özkan AM. Rhododendron L. species and mad honey: systematic review. Journal of Literature Pharmacy Sciences. 2023; 12: 135–142. (In Turkish)

[10] Seyrekoğlu F, Acun S. Use of herbal products in foods. 1st edn. Livre de Lyon: France. 2023.

[11] Yengil E, Akhan MM, Yengil D, Evren H, Öztürkoğlu HE, Şilfeler I, et al. A family admission for poisoning with mad honey: a case report. Turkish Journal of Family Practice. 2013; 17: 134–136. (In Turkish)

[12] Babayiğit M, Baykal Tutal Z, Güleç H, Kütük S, Şahap M, Horasanlı E. Wild honey intoxication: case report. Journal of Contemporary Medicine. 2013; 3: 197–199.

[13] Aksoy F, Baş HA, Özaydın M, Arslan A, Kapçı M. Mad honey poisoning; case report. Medical Journal of Süleyman Demirel University. 2013; 20: 155–157. (In Turkish)

[14] Al-Saedi NJJ, Al-Ameri LKJ, Mahdi SA. Medicinal importance of Atropa belladonna plant (tropane alkaloids). Kirkuk University Journal for Agricultural Sciences. 2023; 14: 88–97.

[15] Caksen H, Odabaş D, Akbayram S, Cesur Y, Arslan S, Uner A, et al. Deadly nightshade (Atropa belladonna) intoxication: an analysis of 49 children. Human & Experimental Toxicology. 2023; 22: 665–668.

[16] Boskabadi SJ, Ramezaninejad S, Zakariaei Z. Severe neurotoxicity due to Atropa belladonna poisoning: a case report and literature review. Case Reports in Neurological Medicine. 2024; 2024: 5411258.

[17] Bol O, Yılmaz G, Biçer M, Doğan Ö, Karaca B. Atropa belladonna intoxication. Journal of Advanced Medical and Educational Research. 2022; 7: 1–4.

[18] Sarıtaş A, Korkmaz M, Kurnaz MM. Three geriatric patients presenting with Atropa belladonna (deadly nightshade) poisoning within 5 days. Journal of Academic Emergency Medicine Case Reports. 2014; 5: 161–164.

[19] Demir C, Dülger C, Mete R, Arslan Ş, Dilek İ. Poisoning with Atropa belladonna: a case report. Van Medical Journal. 2006; 13: 61–63. (In Turkish)

[20] Demirhan A, Tekelioğlu ÜY, Yıldız İ, Korkmaz T, Bilgi M, Akkaya A, et al. Atropa bellodonna fruit (deadly nightshade) related anticholinergic toxic syndrome: a case report. Turkish Journal of Anaesthesiology and Reanimation. 2013; 41: 226–228.

[21] Boskabadi J, Askari Z, Zakariaei Z, Fakhar M, Tabaripour R. Mild-to-severe poisoning due to Conium maculatum as toxic herb: a case series. Clinical Case Reports. 2021; 9: e04509.

[22] Dayan AD. Death of socrates: a likely case of poison hemlock (Conium maculatum) poisoning. Clinical Toxicology. 2024; 62: 56–60.

[23] Büyük Y, Özdeş T, Üzün İ, Özbay M, Kumral B. Death with hemlock poisonıng: a case report. Journal of Translational Medicine. 2013; 27: 199–204.

[24] Akçay N, Sofuoğlu Aİ, Koçoğlu Barlas Ü, Özçelik G, Boydağ Güvenç K, Şevketoğlu E. Respiratory failure due to hemlock intoxication: a case report. Turkish Journal of Pediatric Disease. 2021; 15: 84–86.

[25] Konca C, Kahramaner Z, Bosnak M, Kocamaz H. Hemlock (Conium maculatum) poisoning in a child. Turkish Journal of Emergency Medicine. 2016; 14: 34–36.

[26] Süzgeç-Selçuk S, Özek T, Özek G, Yur S, Göger F, Gürdal MB, et al. The leaf and the gall volatiles of Salvia fruticosa miller from Turkey: chemical composition and biological activities. Records of Natural Products. 2021; 15: 1, 10–24.

[27] Gündüz S, Kara S, Yüksel ÇN, Yılmaz AE. Four intoxication cases related to the misuse of sage oil. Dicle Medical Journal. 2016; 43: 364–366.

[28] Muderawan IW, Tika IN, Karyasa IW, Widana GAB. Chemistry and biology of cyanides: a literature review. Indonesian Journal of Chemistry and Environment. 2023; 6: 63–82.

[29] Hon KL, Hui WF, Leung AKC. Antidotes for childhood toxidromes. Drugs in Context. 2021; 10: 1–10.

[30] Kaya A, Okur M, Üstyol L, Temel H, Çaksen H. Acute cyanide poisoning after eating apricot pits: a case report. Turkish Archives of Pediatrics. 2012; 47: 140–141.

[31] Yeşilbaş O, Balkı HG, Bayrak M, Ülgen Tekerek N. Potential and natural cyanide poison for children: apricot kernels. Journal of Pediatric Emergency and Intensive Care Medicine. 2019; 6: 109–112.

[32] Bıcılıoğlu Y, Yıldırım İ, Yazıcı Özkaya P, Bal A. Pediatric cyanide poisoning after ingestion of apricot seeds. Journal of Pediatric Emergency and Intensive Care Medicine. 2020; 7: 85–88.

[33] Demir G, Bardak Ş, Dadashova L, Yüksel NC, Elibol P, Çiçek A, et al. From pre-diagnosis of encephalitis to poisoning: acute cyanide poisoning. Turkish Journal of Pediatrics. 2021; 15: 542–544.

[34] Anzano A, Falco B, Grauso L, Lanzotti V. Squirting cucumber, Ecballium elaterium (L.) A. Ritch: an update of its chemical and pharmacological profile. Molecules. 2024; 29: 4377.

[35] El Zahran T, Halabi Z, Barakat A, Imad El Hachem R, Nicolas CB, Al Hassan S, et al. An overview of the poisonous plants of Lebanon and their effects. Toxicon. 2024; 252: 108177.

[36] Aydın İ, Karadaş S, Gönüllü H, Selvi F. Uvular edema due to Ecbalium elaterium: a case report. Journal of Academic Emergency Medicine Case Reports. 2012; 3: 49–51.

[37] Kavalcı C, Durukan P, Cevik Y, Ozer M. Angioedema due to Ecballium elaterium: case report. Journal of Academic Emergency Medicine. 2007; 6: 39–40.

[38] Sarı Gökay S, Tolu Kendir Ö, Yılmaz HL. Ecballium elaterium poisoning in pediatric emergency service: a case report. International Journal of Pediatrics. 2018; 6: 6977–6980.

[39] Tariq M, Ahmad Z, Shah SA, Gul Z, Khan SA. Phytochemical analysis and antibacterial activity of Nicotiana tabacum and Nicotiana rustica. Phytochemical Analysis & Antibacterial Activity of Tobacco Plants. 2021; 12: 59–63.

[40] Güzel A. Tobacco plant and pharmacological properties; is it really devil weed. Updates on Pulmonary Diseases. 2016; 4: 22–26. (In Turkish)

[41] Leon ME, Peruga A, McNeill A, Kralikova E, Guha N, Minozzi S, et al. European Code against Cancer, 4th Edition: Tobacco and cancer. Cancer Epidemiology. 2015; 39S: S20–S33.

[42] Begaliyev BS, Işıkov İA. Effects of Nicotiana rustica/Nicotiana tabacum (Maras Otu) on oral mucosa. 2017. Available at: https://dergipark.org.tr/tr/pub/otd/issue/28818/308078 (Accessed: 31 May 2025).

[43] Akpınar M, Müslehiddinoğlu M, Özcan M, Sarıcı SÜ. An herbal danger: dieffenbachia. Journal of Child Health and Diseases. 2016; 59: 21–23. (In Turkish)

[44] Engin MMN, Balcı H, Timur F, Temizkan RC, Kılıçaslan Ö, Kocabay K. A case of rarely seen poisoning in pediatric emergency department: dieffenbachia ornamental plant. Pamukkale Medical Journal. 2018; 11: 179–181. (In Turkish)

[45] Akça H, Polat E, Tuygun N, Kaya NG, Karacan CD. Hazard at home: dieffenbachia. Journal of Academic Emergency Medicine Case Reports. 2014; 5: 107–109. (In Turkish)

[46] Ataş Berksoy E, Topalakçı E, Bekem Soylu Ö, Çelik T. Accidental poisoning of a child by dieffenbachia. Journal of Pediatric Emergency and Intensive Care Medicine. 2018; 5: 86–88.

[47] Yardan T, Eden AO, Baydın A, Arslan B, Vural K. Mushroom poisoning. Ondokuz Mayis University Journal of Medicine. 2008; 25: 75–83. (In Turkish)

[48] Dönmez O, Çetinkaya M, Emir G. Hemoperfusion in Amanita phalloides poisoning: report of two cases. Turkish Society of Nephrology. 2001; 10: 254–256. (In Turkish)

[49] Yıldırım İ, Şahin A, Baran O, Arar MC, Sarıkaya HG. Successful treatment of mushroom poisoning with silybin: a case report. Turkish Journal of Intensive Care. 2019; 17: 166–171.

[50] Karakoç E, Demirtaş K, Ekemen S, Ayyıldız A, Yelken B. Mushroom that break hearts: a case report. Turkish Journal of Intensive Care. 2020; 18: 43–46.

[51] Aydın MF, Sezen M, Oruç A, Yıldız A, Özerik K, Aslan H, et al. Three cases of mushroom poisoning with an unexpected initial presentation: acute kidney injury with Amanita proxima poisoning. Renal Replacement Therapy. 2023; 9: 63.

[52] Farzaei MH, Bayrami Z, Farzaei F, Aneva I, Das SK, Patra JK, et al. Poisoning by medical plants. Archives of Iranian Medicine. 2020; 23: 117–127.

[53] Nițescu GV, Grama A, Turcu T, Strătulă A, Dragomirescu A, Pană ES, et al. Epidemiology and clinical characteristics of acute plant exposure in patients aged between 0 and 18 years—a six-year retrospective study. Children. 2024; 11: 271.

[54] Dayasiri MB, Jayamanne SF, Jayasinghe CY. Plant poisoning among children in rural Sri Lanka. International Journal of Pediatrics. 2017; 2017: 6187487.

[55] Wendt S, Lübbert C, Begemann K, Prasa D, Franke H. Poisoning by plants. Deutsches Arzteblatt International. 2022; 119: 317–324.

[56] Riet-Correa F, Machado M, Micheloud JF. Plants causing poisoning outbreaks of livestock in South America: a review. Toxicon: X. 2023; 17: 100150.

[57] Fatur K, Kreft S. Common anticholinergic solanaceaous plants of temperate Europe—a review of intoxications from the literature (1966–2018). Toxicon. 2020; 177: 52–88.

[58] Hani N, Baydoun S, Nasser H, Ulian T, Arnold-Apostolides N. An ethnobotanical survey of poisonous medicinal plants in the Shouf Biosphere Reserve, Lebanon. Journal of Ethnobiology and Ethnomedicine. 2022; 18: 73.

[59] Diaz JH. Poisoning by herbs and plants: rapid toxidromic classification and diagnosis. Wilderness & Environmental Medicine. 2016; 27: 136–152.


Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.3 (2024) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Top