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Original Research

Open Access

Prevalence and consequences of central venous catheter malposition in critically ill pediatric patients

  • Seher Erdogan1,*,
  • İlknur Pence2
  • Mahmud Esad Pence3
  • Hazal Ceren Tugrul1
  • Ceren Bilgun1
  • Gurkan Atay1

1Department of Pediatric Critical Care, Umraniye Research and Training Hospital, Faculty of Medicine, Health Science University, 34764 İstanbul, Türkiye

2Department of Pediatrics, Umraniye Research and Training Hospital, Faculty of Medicine, Health Sciences University, 34764 İstanbul, Türkiye

3Department of Biochemistry, Faculty of Medicine, Marmara University, 34854 İstanbul, Türkiye

DOI: 10.22514/sv.2025.127 Vol.21,Issue 9,September 2025 pp.43-49

Submitted: 09 December 2024 Accepted: 26 March 2025

Published: 08 September 2025

*Corresponding Author(s): Seher Erdogan E-mail: seher.erdogan@sbu.edu.tr

Abstract

Background: This study aimed to determine the prevalence of malpositioning of central venous catheters inserted into the internal jugular and subclavian veins and to identify the risk factors associated with such positioning in children. Methods: A retrospective cohort study in a pediatric intensive care unit (ICU) radiologically assessed central venous catheters (CVC) position in patients aged one month to 18 years from 2023 to 2024. Positioning was categorized based on proximity to the carina: “Good” (between the carina and two vertebral bodies below), “High” (above the carina), “Low” (below two vertebral bodies) and “Abnormal” (outside these regions). The associations between patient demographics, clinical data, and catheter tip positions were analyzed. Results: Out of 214 pediatric patients, 52.8% were males, with a median age of 35 months. Catheter tip positioning was classified as “good” (62.1%), “high” (17.7%), “low” (17.2%) and “other” (2.8%). Notably, High tip positions were associated with older and heavier patients, while Low tip positions were more common in younger and lighter patients. Patients weighing 20–40 kg had nearly three times higher odds of “High” catheter tip positions than those weighing 0–10 kg (p = 0.032). Temporary CVCs were five times more likely to result in “High” positions (p = 0.035). Right-sided placement reduced the risk of “High” positions by 71% (p = 0.002). In comparison, higher weight categories (10–20 kg and ≥40 kg) lowered the odds of “Low” positions by 79% and 74%, respectively (p = 0.004 and p = 0.025). Conclusions: In critically ill pediatric patients, the incidence of malposition in CVCs remains significantly high, influenced by factors type and location of catheter placement, direction of insertion and the patient’s age and weight.


Keywords

Central venous catheter malposition; Pediatric ıntensive care; Pediatric catheterization


Cite and Share

Seher Erdogan,İlknur Pence,Mahmud Esad Pence,Hazal Ceren Tugrul,Ceren Bilgun,Gurkan Atay. Prevalence and consequences of central venous catheter malposition in critically ill pediatric patients. Signa Vitae. 2025. 21(9);43-49.

References

[1] Misirlioglu M, Yildizdas D, Yavas DP, Ekinci F, Horoz OO, Yontem A. Central venous catheter insertion for vascular access: a 6-year single-center experience. Indian Journal of Critical Care Medicine. 2023; 27: 748–753.

[2] Christison-Lagay ER, Brown EG, Bruny J, Funaro M, Glick RD, Dasgupta R, et al. Central venous catheter consideration in pediatric oncology: a systematic review and meta-analysis from the American pediatric surgical association cancer committee. Journal of Pediatric Surgery. 2024; 59: 1427–1443.

[3] Hofmann S, Goedeke J, König TT, Poplawski A, Muensterer OJ, Faber J, et al. Multivariate analysis on complications of central venous access devices in children with cancer and severe disease influenced by catheter tip position and vessel insertion site (A STROBE-compliant study). Surgical Oncology. 2020; 34: 17–23.

[4] Scott WL. Central venous catheters: an overview of food and drug administration activities. Surgical Oncology Clinics of North America. 1995; 4: 377–393.

[5] Shepherd NM, Carle C. Should all critical care patients with a central venous catheter in situ be screened for central catheter related thrombosis? British Journal of Hospital Medicine. 2024; 85: 1–3.

[6] Teja B, Bosch NA, Diep C, Pereira TV, Mauricio P, Sklar MC, et al. Complication rates of central venous catheters: a systematic review and meta-analysis. JAMA Internal Medicine. 2024; 184: 474–482.

[7] Rockholt MM, Thorarinsdottir HR, Lazarevic V, Rundgren M, Kander T. Central venous catheter-related complications in hematologic patients: an observational study. Acta Anaesthesiologica Scandinavica. 2022; 66: 473–482.

[8] Ablordeppey EA, Huang W, Holley I, Willman M, Griffey R, Theodoro DL. Clinical practices in central venous catheter mechanical adverse events. Journal of Intensive Care Medicine. 2022; 37: 1215–1222.

[9] Greca A, Iacobone E, Elisei D, Biasucci DG, D’Andrea V, Barone G, et al. ECHOTIP: A structured protocol for ultrasound-based tip navigation and tip location during placement of central venous access devices in adult patients. The Journal of Vascular Access. 2023; 24: 535–544.

[10] Baskin KM, Jimenez RM, Cahill AM, Jawad AF, Towbin RB. Cavoatrial junction and central venous anatomy: implications for central venous access tip position. Journal of Vascular and Interventional Radiology. 2008; 19: 359–365.

[11] Farhadi E, Aslanabadi S, Badebarin D, Jamshidi M, Ladan AH, Hasanzadeh N, et al. Comparison of open and ultrasound-guided placement of central venous catheter in children weighing less than five kilograms; a randomized clinical trial. Academic Radiology. 2023; 30: 1419–1425.

[12] Kleidon TM, Schults J, Paterson R, Rickard CM, Ullman AJ. Comparison of ultrasound-guided peripheral intravenous catheter insertion with landmark technique in paediatric patients:0020a systematic review and meta-analysis. Journal of Paediatrics and Child Health. 2022; 58: 953–961.

[13] Ruesch S, Walder B, Tramèr MR. Complications of central venous catheters: internal jugular versus subclavian access--a systematic review. Critical Care Medicine. 2002; 30: 454–460.

[14] Schummer W, Schummer C, Rose N, Niesen WD, Sakka SG. Mechanical complications and malpositions of central venous cannulations by experienced operators. A prospective study of 1794 catheterizations in critically ill patients. Intensive Care Medicine. 2007; 33: 1055–1059.

[15] Weber MD, Conlon T, Woods-Hill C, Watts SL, Nelson E, Traynor D, et al. Retrospective assessment of patient and catheter characteristics associated with malpositioned central venous catheters in pediatric patients. Pediatric Critical Care Medicine. 2022; 23: 192–200.

[16] Barone G, Pittiruti M, Biasucci DG, Elisei D, Iacobone E, La Greca A, et al. Neo-ECHOTIP: a structured protocol for ultrasound-based tip navigation and tip location during placement of central venous access devices in neonates. The Journal of Vascular Access. 2022; 23: 679–688.

[17] Tran QK, Foster M, Bowler J, Lancaster M, Tchai J, Andersen K, et al. Emergency and critical care providers' perception about the use of bedside ultrasound for confirmation of above-diaphragm central venous catheter placement. Heliyon. 2020; 6: e03113.

[18] Zhang Y, Yan A, Liu Y. The advantage of point-of-care ultrasound in central venous catheterization and related pericardial effusion in infants in the NICU. Frontiers in Pediatrics. 2023; 11: 1228070.

[19] Rossetti F, Pittiruti M, Lamperti M, Graziano U, Celentano D, Capozzoli G. The intracavitary ECG method for positioning the tip of central venous access devices in pediatric patients: results of an Italian multicenter study. The Journal of Vascular Access. 2015; 16: 137–143.

[20] Pittiruti M, Lamperti M. Late cardiac tamponade in adults secondary to tip position in the right atrium: an urban legend? A systematic review of the literature. Journal of Cardiothoracic and Vascular Anesthesia. 2015; 29: 491–495.

[21] Korkmaz UTK, Uçaroğlu ER. Catheter malposition as a considerable complication of central venous catheterization: an analysis of 23 cases in a tertiary referral hospital. Journal of Ankara University Faculty of Medicine. 2021; 74: 42–47.

[22] Maddali MM, Al Aliyani KRS, Arora NR, Sathiya PM. Central venous catheter tip malposition after internal jugular vein cannulation in pediatric patients with congenital heart disease. Journal of Cardiothoracic and Vascular Anesthesia. 2022; 36: 2483–2487.

[23] Tanyıldızı B. Rare central venous catheter malpositions: a case series. Cureus. 2024; 16: e63872.

[24] de Man L, Wentzel M, van Rooyen C, Turton E. Comparison between ultrasound and chest X-ray to confirm central venous catheter tip position. South African Journal of Radiology. 2023; 27: 2587.

[25] Picardi M, Giordano C, Della Pepa R, Pugliese N, Esposito M, Abagnale DP, et al. Intravascular complications of central venous catheterization by insertion site in acute leukemia during remission induction chemotherapy phase: lower risk with peripherally inserted catheters in a single-center retrospective study. Cancers. 2023; 15: 2147.

[26] Ren Y, Chang L, Zhao B, Zhang X, Wan Y, Zhu X, et al. Venous thromboembolism after peripherally inserted central catheters placement in children with acute leukemia: a single-center retrospective cohort study. Journal of Pediatric Hematology/Oncology. 2020; 42: e407–e409.

[27] López-Rubio M, Lago-Rodríguez MO, Ordieres-Ortega L, Oblitas CM, Moragón-Ledesma S, Alonso-Beato R, et al. A comprehensive review of catheter-related thrombosis. Journal of Clinical Medicine. 2024; 13: 7818.

[28] Fu M, Yuan Q, Yang Q, Yu Y, Song W, Qin X, et al. Risk factors and incidence of central venous access device-related thrombosis in hospitalized children: a systematic review and meta-analysis. Pediatric Research. 2024; 96: 1568–1593.

[29] Saavedra-Lozano J, Slocker-Barrio M, Fresán-Ruiz E, Grasa C, Martín Pedraz L, Menasalvas Ruiz A, et al. Consensus document of the spanish society of paediatric infectious diseases (SEIP) and the spanish society of paediatric intensive care (SECIP) for the diagnosis and treatment of central venous catheter-related infections in paediatric care. Anales de Pediatría. 2024; 100: 448–464.

[30] Khieosanuk K, Fupinwong S, Tosilakul A, Sricharoen N, Sudjaritruk T. Incidence rate and risk factors of central line-associated bloodstream infections among neonates and children admitted to a tertiary care university hospital. American Journal of Infection Control. 2022; 50: 105–107.


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