Hemodynamic effects of desflurane and sevoflurane low-flow anesthesia for laparoscopic sleeve gastrectomy

Background: This study aimed to evaluate the hemodynamic effects of sevoflurane and desflurane in low-flow anesthesia during laparoscopic sleeve gastrectomy (LSG). Despite their increasing use, their hemodynamic effects in low-flow anesthesia for this high-risk population remain underexplored. Methods: This retrospective comparative study analyzed 79 patients who underwent LSG between 2022 and 2025. Patients were divided into two groups: 37 received low-flow sevoflurane, and 42 received low-flow desflurane. Hemodynamic parameters, including heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and peripheral oxygen saturation (SpO2), were recorded at predefined time points. Groups were statistically compared in terms of hemodynamic stability. Results: Both anesthetic agents maintained overall hemodynamic stability throughout the surgery, with no significant differences in SBP, DBP, HR or SpO2 at any time point (p > 0.05). Conclusions: Both sevoflurane and desflurane provide stable hemodynamic conditions in low-flow anesthesia for laparoscopic bariatric surgery. These findings support the safety and feasibility of low-flow anesthesia in this patient population. Future prospective studies with larger sample sizes and diverse patient cohorts are needed to further validate these results and strengthen their clinical applicability.

Low-flow anesthesia; Obesity; Bariatric surgery; Sevoflurane; Desflurane; Hemodynamic stability

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