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Low cardiac output syndrome after adult cardiac surgery

  • Alessandro Belletti1,*,
  • Vladimir V. Lomivorotov2
  • Alberto Zangrillo1,3
  • Marina Pieri1,3

1Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

2Department of Anesthesiology and Perioperative Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA

3School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy

DOI: 10.22514/sv.2025.167 Vol.21,Issue 11,November 2025 pp.1-16

Submitted: 28 January 2025 Accepted: 29 August 2025

Published: 08 November 2025

*Corresponding Author(s): Alessandro Belletti E-mail: belletti.alessandro@hsr.it

Abstract

Low cardiac output syndrome (LCOS) occurs frequently after cardiac surgery, and is associated with complications. Causes of LCOS include ventricular dysfunction, hemorrhage, cardiac tamponade, or arrhythmias. Management remains supportive, as etiology is identified in a minority of cases. Management includes inotropes and vasopressors, and optimization of intravascular volume and heart rhythm. A temporary epicardial pacemaker for bradyarrhythmias may be helpful. In profound cardiogenic shock, mechanical circulatory support (MCS) is required. However, ideal inotrope/vasopressors combinations, hemodynamic targets and timing of MCS initiation are not described in the literature. In this narrative review, we summarize current definition, occurrence rate, and treatment of LCOS following adult cardiac surgery.


Keywords

Cardiac surgery; Hemodynamic management; Low cardiac output syndrome; Cardiogenic shock; Mechanical circulatory support; Catecholamines


Cite and Share

Alessandro Belletti,Vladimir V. Lomivorotov,Alberto Zangrillo,Marina Pieri. Low cardiac output syndrome after adult cardiac surgery. Signa Vitae. 2025. 21(11);1-16.

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