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Original Research

Open Access

Hemoglobin, albumin, lymphocyte and platelet (HALP) score effectiveness in peptic ulcer perforation

  • Osman Bardakçı1,*,
  • Gokay Cetinkaya2

1Department of Surgical Oncology, Isparta City Hospital, 32200 Isparta, Turkey

2Department of Surgical Oncology, Ankara Gülhane Research and Training Hospital, 06010 Ankara, Turkey

DOI: 10.22514/sv.2025.173 Vol.21,Issue 11,November 2025 pp.76-81

Submitted: 08 February 2025 Accepted: 03 April 2025

Published: 08 November 2025

*Corresponding Author(s): Osman Bardakçı E-mail: drosmanbardakci@gmail.com

Abstract

Background: Peptic ulcer perforation (PUP) has mortality rates up to 30%. This study aims to determine whether the “emoglobin, albumin, lymphocyte and platelet” (HALP) score is effective in predicting morbidity and mortality of PUP cases. Methods: This retrospective study was conducted from January 2019 to September 2023, at the General Surgery Clinic of Isparta City Hospital. Patients included in this research underwent surgery after being diagnosed with PUP. Demographic data and HALP score were collected. To analyze the HALP score’s prognostic significance, Receiver Operating Characteristic (ROC) Curve analysis was performed, and a ROC curve was created. Sample size was calculated using G*Power program. Results: The study included 141 patients (112 males, 29 females), 55.97 ± 21.51 (18–97) years old. Patients with complications and mortality had lower HALP scores in comparison to patients without complications and mortality (p < 0.001). Conclusions: The HALP score is calculated with simple laboratory data and is a cheap and easy scoring system to predict post-surgical complications and mortalities in PUP patients.


Keywords

HALP score; Mortality; Morbidity; Surgery; Emergency; Peptic ulcer perforation


Cite and Share

Osman Bardakçı, Gokay Cetinkaya. Hemoglobin, albumin, lymphocyte and platelet (HALP) score effectiveness in peptic ulcer perforation. Signa Vitae. 2025; 21(11): 76-81. doi: 10.22514/sv.2025.173

References

[1] Koranne A, Byakodi KG, Teggimani V, Kamat VV, Hiregoudar A. A comparative study between peptic ulcer perforation score, Mannheim peritonitis index, ASA score, and Jabalpur score in predicting the mortality in perforated peptic ulcers. Surgery Journal. 2022; 8: e162–e168.

[2] Sonnenberg A. Time trends of ulcer mortality in Europe. Gastroenterology. 2007; 132: 2320–2327.

[3] Lanas A, García-Rodríguez LA, Polo-Tomás M, Ponce M, Quintero E, Perez-Aisa MA, et al. The changing face of hospitalisation due to gastrointestinal bleeding and perforation. Alimentary Pharmacology & Therapeutics. 2011; 33: 585–591.

[4] Vakil N. Peptic ulcer disease: a review. JAMA. 2024; 332: 1832–1842.

[5] Dadfar A, Edna TH. Epidemiology of perforating peptic ulcer: a population-based retrospective study over 40 years. World Journal of Gastroenterology. 2020; 26: 5302–5313.

[6] Lau JY, Sung J, Hill C, Henderson C, Howden CW, Metz DC. Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality. Digestion. 2011; 84: 102–113.

[7] Tarasconi A, Coccolini F, Biffl WL, Tomasoni M, Ansaloni L, Picetti E, et al. Perforated and bleeding peptic ulcer: WSES guidelines. World Journal of Emergency Surgery. 2020; 15: 3.

[8] Stern E, Sugumar K, Journey JD. Peptic ulcer perforated. StatPearls Publishing: Treasure Island (FL). 2023.

[9] Søreide K, Thorsen K, Harrison EM, Bingener J, Møller MH, Ohene-Yeboah M, et al. Perforated peptic ulcer. The Lancet. 2015; 386: 1288–1298.

[10] Huang YK, Wu KT, Su YS, Chen CY, Chen JH. Predicting in-hospital mortality risk for perforated peptic ulcer surgery: the PPUMS scoring system and the benefit of laparoscopic surgery: a population-based study. Surgical Endoscopy. 2023; 37: 6834–6843.

[11] Velde G, Ismail W, Thorsen K. Perforated peptic ulcer. British Journal of Surgery. 2024; 111: znae 224.

[12] Wang YH, Wu YT, Fu CY, Liao CH, Cheng CT, Hsieh CH. Potential use of peptic ulcer perforation (PULP) score as a conversion index of laparoscopic-perforated peptic ulcer (PPU) repair. European Journal of Trauma and Emergency Surgery. 2022; 48: 61–69.

[13] Lim RZM, Tan JH, Raja Ram NK, Tan HCL, Ho IKE, Chuah JS, et al. A comparative analysis of Charlson’s weighted index of comorbidity and perforated peptic ulcer scores in predicting postoperative mortality and high comprehensive complication index. World Journal of Surgery. 2024; 48: 1373–1384.

[14] Chen XL, Xue L, Wang W, Chen HN, Zhang WH, Liu K, et al. Prognostic significance of the combination of preoperative hemoglobin, albumin, lymphocyte and platelet in patients with gastric carcinoma: a retrospective cohort study. Oncotarget. 2015; 6: 41370–41382.

[15] Zuo L, Dong Y, Liao X, Hu Y, Pan Y, Yan H, et al. Low HALP (hemoglobin, albumin, lymphocyte, and platelet) score increases the risk of post-stroke cognitive impairment: a multicenter cohort study. Clinical Interventions in Aging. 2024; 19: 81–92.

[16] Park PG, Yoo BW, Song JJ, Park YB, Lee SW. Will the HALP score help to assess the activity and predict the prognosis of antineutrophil cytoplasmic antibody-associated vasculitis? Clinical and Experimental Rheumatology. 2020; 38: 236–237.

[17] Kocaoglu S, Alatli T. The efficiency of the HALP score and the modified HALP score in predicting mortality in patients with acute heart failure presenting to the emergency department. Journal of College of Physicians and Surgeons Pakistan. 2022; 32: 706–711.

[18] Cay F, Duran A. Predictive factors of success in sleeve gastrectomy: one-year follow-up and the significance of HALP score. Journal of College of Physicians and Surgeons Pakistan. 2021; 31: 1406–1411.

[19] Stettler GR, Follette CJ, Avery MD. Surgical management of perforated peptic ulcers. Current Surgery Reports. 2025; 13: 9.

[20] Casali JJ, Franzon O, Kruel NF, Neves BD. Epidemiological analysis and use of rapid urease test in patients with perforated peptic ulcers. Revista do Colégio Brasileiro de Cirurgiões. 2012; 39: 93–98.

[21] Thorsen K, Søreide JA, Søreide K. Scoring systems for outcome prediction in patients with perforated peptic ulcer. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2013; 21: 25.

[22] Kocer B, Surmeli S, Solak C, Unal B, Bozkurt B, Yildirim O, et al. Factors affecting mortality and morbidity in patients with peptic ulcer perforation. Journal of Gastroenterology and Hepatology. 2007; 22: 565–570.

[23] Abouelazayem M, Jain R, Wilson MSJ, Martinino A, Balasubaramaniam V, Biffl W, et al.; GRACE Study Collaborative Group. Global 30-day morbidity and mortality of surgery for perforated peptic ulcer: GRACE study. Surgical Endoscopy. 2024; 38: 4402–4414.

[24] Ahmed M, Mansoor T, Rab AZ, Rizvi SAA. Risk factors influencing postoperative outcome in patients with perforated peptic ulcer: a prospective cohort study. European Journal of Trauma and Emergency Surgery. 2022; 48: 81–86.

[25] Seyoum N, Ethicha D, Assefa Z, Nega B. Risk factors that affect morbidity and mortality in patients with perforated peptic ulcer diseases in a teaching hospital. Ethiopian Journal of Health Sciences. 2020; 30: 549–558.

[26] Farag CM, Antar R, Akosman S, Ng M, Whalen MJ. What is hemoglobin, albumin, lymphocyte, platelet (HALP) score? A comprehensive literature review of HALP’s prognostic ability in different cancer types. Oncotarget. 2023; 14: 153–172.

[27] Antar R, Farag C, Xu V, Drouaud A, Gordon O, Whalen MJ. Evaluating the baseline hemoglobin, albumin, lymphocyte, and platelet (HALP) score in the United States adult population and comorbidities: an analysis of the NHANES. Frontiers in Nutrition. 2023; 10: 1206958.

[28] Li H, Zhou Y, Zhang X, Yao R, Li N. The relationship between hemoglobin, albumin, lymphocyte, and platelet (HALP) score and 28-day mortality in patients with sepsis: a retrospective analysis of the MIMIC-IV database. BMC Infectious Diseases. 2025; 25: 333.

[29] Xu H, Zheng X, Ai J, Yang L. Hemoglobin, albumin, lymphocyte, and platelet (HALP) score and cancer prognosis: a systematic review and meta-analysis of 13,110 patients. International Immunopharmacology. 2023; 114: 109496.

[30] Güler İ, Ustaalioğlu İ. Predictive power of HALP score in estimating short-term mortality in patients with acute pancreatitis. Turkish Journal of Trauma & Emergency Surgery. 2023; 29: 1098–1102.

[31] Benli S, Tazeoğlu D. The efficacy of hemoglobin, albumin, lymphocytes, and platelets (HALP) score in signifying acute appendicitis severity and postoperative outcomes. Updates in Surgery. 2023; 75: 1197–1202.


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