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Too soon to deflate? Rethinking IABP in the era of Altshock-2

  • Maks Mihalj1
  • Charles Wanna1
  • Sriram Nathan1
  • Harish Devineni1
  • Alessandro Belletti2
  • Anna Mara Scandroglio2
  • Igor D. Gregoric1
  • Angelo Nascimbene1,*,
  • Biswajit Kar1

1Department of Advanced Cardiopulmonary Therapies and Transplantation, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030, USA

2Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

DOI: 10.22514/sv.2025.189 Vol.21,Issue 12,December 2025 pp.1-3

Submitted: 27 September 2025 Accepted: 11 October 2025

Published: 08 December 2025

*Corresponding Author(s): Angelo Nascimbene E-mail: angelo.nascimbene@uth.tmc.edu

Abstract

Mechanical circulatory support (MCS) is frequently used in patients with cardiogenic shock to restore adequate organ perfusion, improve hemodynamic, reduce catecholamine-related adverse events, and prevent development of organ failure. Intra-aortic balloon pump (IABP) is usually the first line device used among currently available MCS systems, it is easily inserted at bedside, and associated with low complications rate. Despite its widespread use, a recent small, randomized study suggested that early implantation of IABP does not improve short-term outcomes in patients with Society of Cardiovascular Angiography Class B to D heart-failure related cardiogenic shock. In this article, we discuss possible limitations of recent studies on IABP, as well as updated evidence on effects on outcome and optimal patient selection for IABP support in patients with heart-failure related cardiogenic shock.


Keywords

Cardiogenic shock; Mechanical circulatory support; Intra-aortic balloon pump; Micro-axial flow pump; Adverse events


Cite and Share

Maks Mihalj,Charles Wanna,Sriram Nathan,Harish Devineni,Alessandro Belletti,Anna Mara Scandroglio,Igor D. Gregoric,Angelo Nascimbene,Biswajit Kar. Too soon to deflate? Rethinking IABP in the era of Altshock-2. Signa Vitae. 2025. 21(12);1-3.

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