Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Characteristics, etiologies and outcomes of cardiac arrest in the emergency department
1Department of Emergency Medicine, Chi Mei Medical Center, 710402 Tainan, Taiwan
2Department of Emergency Medicine, Taichung Municipal Geriatric Rehabilitation General Hospital, 406004 Taichung, Taiwan
3Department of Medical Research, Chi Mei Medical Center, 710402 Tainan, Taiwan
4Department of Information Management, Southern Taiwan University of Science and Technology, 710301 Tainan, Taiwan
5Department of Intensive Care Medicine, Chi Mei Medical Center, 710402 Tainan, Taiwan
6School of Medicine, College of Medicine, National Sun Yat-sen University, 804201 Kaohsiung, Taiwan
7Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, 717301 Tainan, Taiwan
DOI: 10.22514/sv.2026.001
Submitted: 15 June 2025 Accepted: 20 August 2025
Online publish date: 06 January 2026
*Corresponding Author(s): Chang-Chih Tsai E-mail: st1095978@yfes.tn.edu.tw
Background: Emergency department cardiac arrests (EDCA) account for approxi-mately 10% of all in-hospital cardiac arrest (CA) events. However, data regarding EDCA remain scarce. Since EDCA has unique characteristics, etiologies, and outcomes, it should be considered distinct from out-of-hospital and in-hospital cardiac arrest. Methods: This study included adult patients who received cardiopulmonary resuscitation in our emergency department for EDCA between 01 January 2019, and 30 June 2023. Patients with a do-not-resuscitate order and those with trauma were excluded. On the basis of the assessment performed by emergency physicians, we divided the patients into unexpected and expected EDCA groups. Results: This study included 266 patients, of whom 93 had experienced an unexpected EDCA. Shockable initial rhythm was observed in 21.05% of the overall cohort. The incidence of initial shockable rhythms and the prevalence of end-stage renal disease were higher in the unexpected EDCA group (40.86% and 22.58%, respectively). The predominant etiologies of EDCA in the expected and unexpected EDCA groups were sepsis (24.86%) and shockable fatal dysrhythmia (40.86%), respectively. The overall probabilities of survival to hospitalization, survival to hospital discharge, and favorable neurological outcomes were 49.62%, 27.44%, and 12.41%, respectively. A trend toward better neurological outcomes was observed in the unexpected EDCA group. Conclusions: Expected and unexpected EDCA events differ in terms of characteristics, etiologies, and outcomes. To enhance care quality and prognosis, these differences should be considered when treatment is being planned for patients with EDCA.
Cardiac arrest; Emergency department cardiac arrest; Unexpected; Neurological outcome; Resuscitation
Hung-Chih Chen,Yi-Chieh Chen,Po-Jung Chen,Ying-Jia Lin,Yi-Chen Chen,Chung-Han Ho,Chen-Wei Wu,Chien-Chin Hsu,Yi Lin,Yu-Hui Lin,Hsin-Min Lee,Chang-Chih Tsai. Characteristics, etiologies and outcomes of cardiac arrest in the emergency department. Signa Vitae. 2026.doi:10.22514/sv.2026.001.
[1] Kimblad H, Marklund J, Riva G, Rawshani A, Lauridsen KG, Djärv T. Adult cardiac arrest in the emergency department—a Swedish cohort study. Resuscitation. 2022; 175: 105–112.
[2] Nolan JP, Soar J, Smith GB, Gwinnutt C, Parrott F, Power S, et al. Incidence and outcome of in-hospital cardiac arrest in the United Kingdom National Cardiac Arrest Audit. Resuscitation. 2014; 85: 987–992.
[3] Hessulf F, Karlsson T, Lundgren P, Aune S, Strömsöe A, Södersved-Källestedt ML, et al. Factors of importance to 30-day survival after in-hospital cardiac arrest in Sweden—a population-based register study of more than 18,000 cases. International Journal of Cardiology. 2018; 255: 237–242.
[4] Mir T, Qureshi WT, Uddin M, Soubani A, Saydain G, Rab T, et al. Predictors and outcomes of cardiac arrest in the emergency department and in-patient settings in the United States (2016–2018). Resuscitation. 2022; 170: 100–106.
[5] Tan SC, Leong BS. Cardiac arrests within the emergency department: an Utstein style report, causation and survival factors. European Journal of Emergency Medicine. 2018; 25: 12–17.
[6] Giamello JD, Bertone C, Lauria G. Emergency department cardiac arrest. Resuscitation. 2022; 175: 175–176.
[7] Kayser RG, Ornato JP, Peberdy MA. Cardiac arrest in the emergency department: a report from the National Registry of Cardiopulmonary Resuscitation. Resuscitation. 2008; 78: 151–160.
[8] Nolan JP, Berg RA, Andersen LW, Bhanji F, Chan PS, Donnino MW, et al. Cardiac arrest and cardiopulmonary resuscitation outcome reports: update of the Utstein Resuscitation Registry Template for in-hospital cardiac arrest. Circulation. 2019; 140: e746–e757.
[9] Phelps R, Dumas F, Maynard C, Silver J, Rea T. Cerebral performance category and long-term prognosis following out-of-hospital cardiac arrest. Critical Care Medicine. 2013; 41: 1252–1257.
[10] Yang TH, Chen KF, Gao SY, Lin CC. Risk factors associated with peri-intubation cardiac arrest in the emergency department. American Journal of Emergency Medicine. 2022; 58: 229–234.
[11] Singh A, Jefferson J. Post-cardiac arrest care. Emergency Medicine Clinics of North America. 2023; 41: 617–632.
[12] Hirsch KG, Abella BS, Amorim E, Bader MK, Barletta JF, Berg K, et al. Critical care management of patients after cardiac arrest: a scientific statement from the American Heart Association and Neurocritical Care Society. Circulation. 2024; 149: E168–E200.
[13] Kim I, Song H, Kim HJ, Park KN, Kim SH, Oh SH, et al. Use of the National Early Warning Score for predicting in-hospital mortality in older adults admitted to the emergency department. Clinical and Experimental Emergency Medicine. 2020; 7: 61–66.
[14] Royal College of Physicians of London. National early warning score (NEWS): standardising the assessment of acute-illness severity in the NHS. Royal College of Physicians of London: London. 2012.
[15] Guarino M, Perna B, Cesaro AE, Maritati M, Spampinato MD, Contini C, et al. 2023 update on sepsis and septic shock in adult patients: management in the emergency department. Journal of Clinical Medicine. 2023; 12: 3188.
[16] Yang TH, Shao SC, Lee YC, Hsiao CH, Yen CC. Risk factors for peri-intubation cardiac arrest: a systematic review and meta-analysis. Biomedical Journal. 2024; 47: 100656.
[17] April MD, Arana A, Reynolds JC, Carlson JN, Davis WT, Schauer SG, et al. Peri-intubation cardiac arrest in the emergency department: a National Emergency Airway Registry (NEAR) study. Resuscitation. 2021; 162: 403–411.
[18] Karamchandani K, Nasa P, Jarzebowski M, Brewster DJ, De Jong A, Bauer PR, et al. Tracheal intubation in critically ill adults with a physiologically difficult airway: an international Delphi study. Intensive Care Medicine. 2024; 50: 1563–1579.
[19] Myatra SN, Divatia JV, Brewster DJ. The physiologically difficult airway: an emerging concept. Current Opinion in Anaesthesiology. 2022; 35: 115–121.
[20] Ravindran R, Kwok CS, Wong CW, Siller-Matula JM, Parwani P, Velagapudi P, et al. Cardiac arrest and related mortality in emergency departments in the United States: analysis of the Nationwide Emergency Department Sample. Resuscitation. 2020; 157: 166–173.
[21] Giamello JD, D’Agnano S, Paglietta G, Bertone C, Bruno A, Martini G, et al. Characteristics, outcome and prognostic factors of patients with emergency department cardiac arrest: a 14-year retrospective study. Journal of Clinical Medicine. 2024; 13: 4708.
[22] Chen PC, Chen JH, Yeh CC, Chang CH, Lin CC, Ng CJ, et al. Prognostic factors for adults with cardiac arrest in the emergency department: a retrospective cohort study. Signa Vitae. 2022; 18: 56–64.
[23] Andersen LW, Holmberg MJ, Berg KM, Donnino MW, Granfeldt A. In-hospital cardiac arrest: a review. JAMA. 2019; 321: 1200–1210.
[24] Wallmuller C, Meron G, Kurkciyan I, Schober A, Stratil P, Sterz F. Causes of in-hospital cardiac arrest and influence on outcome. Resuscitation. 2012; 83: 1206–1211.
[25] Ma KJ, Hsu YC, Pan WW, Chou MH, Chung WS, Wang JY. Effects of emergency department length of stay on inpatient utilization and mortality. Health Economics Review. 2025; 15: 11.
[26] Habib H, Sudaryo MK. Association between the emergency department length of stay and in‑hospital mortality: a retrospective cohort study. Open Access Emergency Medicine. 2023; 15: 313–323.
[27] Balen F, Routoulp S, Charpentier S, Azema O, Houze-Cerfon CH, Dubucs X, et al. Impact of emergency department length of stay on in‑hospital mortality: a retrospective cohort study. European Journal of Emergency Medicine. 2024; 31: 39–45.
[28] Senguldur E, Demir MC, Selki K. Is lactate clearance useful in predicting cardiopulmonary resuscitation outcome and 48-hour mortality? Journal of the College of Physicians and Surgeons Pakistan. 2025; 35: 267–273.
Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.
Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.
Scopus: CiteScore 1.3 (2024) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.
Top