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Inhalational vs. Intravenous anesthesia: is opposition helpful for clinicians?

  • Chiara Adembri1,*,
  • Alessandro Simonini2
  • Elena Giovanna Bignami3
  • Giovanni Landoni4,5

1Anesthesiology, Critical Care and Pain Therapy, Department of Health Sciences, Careggi University Hospital, University of Florence, 50134 Florence, Italy

2Pediatric Anesthesia and Intensive Care Unit, Salesi Children’s Hospital, 60123 Ancona, Italy

3Anesthesiology, Critical Care and Pain Medicine Division, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy

4Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 20126 Milan, Italy

5School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy

DOI: 10.22514/sv.2026.013 Vol.22,Issue 2,February 2026 pp.41-46

Submitted: 17 November 2025 Accepted: 16 December 2025

Published: 08 February 2026

*Corresponding Author(s): Chiara Adembri E-mail: chiara.adembri@unifi.it

Abstract

An intense debate focusing on the polluting effect of volatile anesthetics has recently called into question their role and importance, even though they have been fundamental to general anesthesia until now. In this brief narrative review, we analyze the advantages and limitations of inhalation anesthesia in comparison with intravenous anesthesia in both adult and pediatric populations. The aim of the review is to assist anesthesiologists in making an informed and objective choice between the 2 techniques, considering that a single aspect—environmental pollution—although important, cannot be the only parameter on which to base the decision of how to perform general anesthesia.


Keywords

Inhalational anesthetics; Sevoflurane; Desflurane; Propofol; Total intravenous anesthesia; Pharmacokinetics of inhalational anesthetics; General anesthesia


Cite and Share

Chiara Adembri,Alessandro Simonini,Elena Giovanna Bignami,Giovanni Landoni. Inhalational vs. Intravenous anesthesia: is opposition helpful for clinicians?. Signa Vitae. 2026. 22(2);41-46.

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