Article Data

  • Views 10360
  • Dowloads 174

Original Research

Open Access

Naringin Attenuated Acute Lung Injury in Rat Model with Acute Pancreatitis in Pregnancy through Inactivation of p38 MAPK Pathway

  • Yaqin Li1
  • Li Zhang2
  • Jun Gong2

1Center of Reproductive Medicine, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, P. R. China

2Obstetric, Jinan Maternity and Child Care Hospital, Jinan City, Shandong Province, P. R. China

DOI: 10.22514/sv.2020.16.0079 Vol.16,Issue 2,October 2020 pp.189-194

Published: 28 October 2020

*Corresponding Author(s): Yaqin Li E-mail: yax_li@163.com

Abstract

Acute pancreatitis in pregnancy can cause fetal lung injury. Naringin exhibits ant-inflammation effect against pulmonary injuries. However, whether naringin can alleviate lung injury associated with acute pancreatitis in pregnancy has not been elucidated. Establishment of acute pancreatitis in pregnancy model by sodium taurocholate showed that sodium taurocholate induced obvious pathological changes in pancreas. Histopathological changes in lungs were also aggravated post sodium taurocholate treatment with enhanced inflammation of neutrophils, thickened alveolar walls and alveolus collapse. Diagnostic blood tests for acute pancreatitis in pregnancy indicated that serum amylase and lipase were increased post sodium taurocholate treatment. Sodium taurocholate-induced rats were intragastrically administered with naringin to investigate the protective effect of naringin on acute lung injury induced by acute pancreatitis in pregnancy. Results revealed that administration of naringin could attenuate pathological changes in pancreas and lungs and decrease amylase and lipase. Moreover, naringin treatment attenuated sodium taurocholate-induced increase in inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-6/1β in lungs. Sodium taurocholate-induced increase in phosphorylation of p38 was also reduced post naringin treatment. In conclusion, naringin could ameliorate acute lung injury and inflammation induced by acute pancreatitis in pregnancy by inhibiting the p38 pathway.

Keywords

Naringin, Acute lung injury, Inflammation, Acute pancreatitis in pregnancy, p38 MAPK

Cite and Share

Yaqin Li,Li Zhang,Jun Gong. Naringin Attenuated Acute Lung Injury in Rat Model with Acute Pancreatitis in Pregnancy through Inactivation of p38 MAPK Pathway. Signa Vitae. 2020. 16(2);189-194.

References

[1] Mali P. Pancreatitis in pregnancy: etiology, diagnosis, treatment, and outcomes. Hepatobiliary Pancreat Dis Int. 2016;15:434-438.

[2] Akcakaya A, Ozkan OV, Okan I, et al. Endoscopic retrograde cholan-giopancreatography during pregnancy without radiation. World journal of gastroenterology. 2009;15:3649-3652.

[3] Hacker FM, Whalen PS, Lee VR, et al. Maternal and fetal outcomes of pancreatitis in pregnancy. American Journal of Obstetrics and Gynecology. 2015;213:568.e561-568.e565.

[4] Zhao L, Zuo T, Shi Q, et al. A preliminary study on fetal lung injury in a rat model of acute pancreatitis in pregnancy. Pathology - Research and Practice. 2017;213:1370-1377.

[5] Qihui C, Xiping Z, Xianfeng D. Clinical study on acute pancreatitis in pregnancy in 26 cases. Gastroenterology research and practice. 2012;2012:271925-271925.

[6] Souza FR, Fornasier F, Souza LMP, et al. Interaction of naringin and naringenin with DPPC monolayer at the air-water interface. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020;584:124024.

[7] Liu Y, Wu H, Nie Y-c, et al. Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway. International Immunopharma-cology. 2011;11:1606-1612.

[8] Foronjy R, D’Armiento J. The Effect of Cigarette Smoke-derived Oxidants on the Inflammatory Response of the Lung. Clinical and applied immunology reviews. 2006;6:53-72.

[9] Kim JK, Park JH, Ku HJ, et al. Naringin protects acrolein-induced pulmonary injuries through modulating apoptotic signaling and in-flammation signaling pathways in mice. The Journal of Nutritional Biochemistry. 2018;59:10-16.

[10] Zhou Y, Xia H, Zhao L, et al. SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy. Inflammopharmacology. 2019;27:99-107.

[11] Zuo T, Yu J, Wang W-X, et al. Mitogen-Activated Protein Kinases Are Activated in Placental Injury in Rat Model of Acute Pancreatitis in Pregnancy. Pancreas. 2016;45:850-857.

[12] Mei F, Zuo T, Zhao L, et al. Differential JNK, p38 and ERK response to renal injury in a rat model of acute pancreatitis in pregnancy. Archives of Gynecology and Obstetrics. 2018;297:933-942.

[13] Cornell TT, Fleszar A, McHugh W, et al. Mitogen-activated protein kinase phosphatase 2, MKP-2, regulates early inflammation in acute lung injury. American journal of physiology Lung cellular and molecular physiology. 2012;303:L251-L258.

[14] Bi C, Jiang Y, Fu T, et al. Naringin inhibits lipopolysaccharide-induced damage in human umbilical vein endothelial cells via attenuation of inflammation, apoptosis and MAPK pathways. Cytotechnology. 2016;68:1473-1487.

[15] Shi Z, Ye W, Zhang J, et al. LipoxinA4 attenuates acute pancreatitis-associated acute lung injury by regulating AQP-5 and MMP-9 expression, anti-apoptosis and PKC/SSeCKS-mediated F-actin activation. Molecular Immunology. 2018;103:78-88.

[16] Zhu GF, Guo HJ, Huang Y, et al. Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity. Exp Ther Med. 2015;10:2259-2266.

[17] Liu X, Zhu Q, Zhang M, et al. Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway. Oxid Med Cell Longev. 2018;2018:7161592.

[18] Ismail OZ, Bhayana V. Lipase or amylase for the diagnosis of acute pancreatitis? Clinical Biochemistry. 2017;50:1275-1280.

[19] Mizuta M, Nakajima H, Mizuta N, et al. Fas Ligand Released by Activated Monocytes Causes Apoptosis of Lung Epithelial Cells in Human Acute Lung Injury Model in Vitro. Biol Pharm Bull. 2008;31:386-390.

[20] Ren X, Shi Y, Zhao D, et al. Naringin protects ultraviolet B-induced skin damage by regulating p38 MAPK signal pathway. J Dermatol Sci. 2016;82:106-114.

[21] Chen J, Mo H, Guo R, et al. Inhibition of the leptin-induced activation of the p38 MAPK pathway contributes to the protective effects of naringin against high glucose-induced injury in H9c2 cardiac cells. Int J Mol Med. 2014;33:605-612.

[22] Twait E, Williard DE, Samuel I. Dominant negative p38 mitogen-activated protein kinase expression inhibits NF-kappaB activation in AR42J cells. Pancreatology. 2010;10:119-128.

[23] Chen P, Zhang Y, Qiao M, et al. Activated protein C, an anticoag-ulant polypeptide, ameliorates severe acute pancreatitis via regulation of mitogen-activated protein kinases. Journal of Gastroenterology. 2007;42:887-896.

[24] Zhou Y, Zhao L, Mei F, et al. Macrophage migration inhibitory fac-tor antagonist (S,R)3‑(4‑hydroxyphenyl)‑4,5‑dihydro‑5‑isoxazole acetic acid methyl ester attenuates inflammation and lung injury in rats with acute pancreatitis in pregnancy. Mol Med Rep. 2018;17:6576-6584.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.0 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Conferences

Top