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Original Research

Open Access Special Issue

Polydipsia-polyuria syndrome associated with traumatic spinal cord injury

  • Cristina Daia1,2
  • Constantin Munteanu3,4,5
  • Ioana Andone1,2
  • Aura Spinu1,2
  • Cristina Popescu1,2
  • Corneliu Toader6,7
  • Gelu Onose1,2,4

1Department of Medical Rehabilitation, University of Medicine and Pharmacy “Carol Davila”, 4192910 Bucharest, Romania

2Neuromuscular Department, Clinical Emergency Hospital “Bagdasar-Arseni”, 041914 Bucharest, Romania

3Department of Research, Romanian Association of Balneology, 022252 Bucharest, Romania

4Physical and Rehabilitation Medicine & Balneology Research Nucleus, Clinical Emergency Hospital “Bagdasar-Arseni”, 041914 Bucharest, Romania

5Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa”,700454 Iași, Romania

6Department of Neurosurgery, “Carol Davila”, University of Medicine and Pharmacy, 041914 Bucharest, Romania

7Neurosurgery Department, National Institute of Cerebro-Vascular Diseases, 041914 Bucharest, Romania

DOI: 10.22514/sv.2021.104

Submitted: 23 March 2021 Accepted: 19 May 2021

Online publish date: 16 June 2021

*Corresponding Author(s): Constantin Munteanu E-mail:


Introduction: Polydipsia and polyuria associated with traumatic spinal cord injury (SCI) are rare consequences. The hypothetical pathophysiological mechanisms involve mild traumatic brain injury (TBI) and/ or vagus dysfunction associated with spinal cord injury.

Methods: In a retrospective study of 11 patients, we investigated associations between polydipsia-polyuria syndrome and various clinical and therapeutic factors: medullary section syndrome, neurological level, medication, neurosurgical intervention, kinesitherapy program, associated comorbidities, functional level at discharge and patient quality of life (QoL).

Results: The beginning of the kinetic program (Spearman correlation coefficient =0.631) and desmopressin treatment (Spearman correlation coefficient =0.708) had statistically significant effects on resolution of polydipsia-polyuria syndrome (PPS). Patient QoL was statistically significant improved after resolution of PPS (t-test, p =0.001).

Conclusions: Mobilization programs appear to promote resolution of PPS. Desmo-pressin treatment is beneficial and, together, medication and kinesitherapy elevate patients’ QoL. The association between SCI and transient PPS requires additional investigation in additional patients.


Polyuria; Polydipsia; Spinal cord injury

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Cristina Daia,Constantin Munteanu,Ioana Andone,Aura Spinu,Cristina Popescu,Corneliu Toader,Gelu Onose. Polydipsia-polyuria syndrome associated with traumatic spinal cord injury. Signa Vitae. 2021.doi:10.22514/sv.2021.104.


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