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Special Issue Title:

Spinal Cord Injury

Deadline for manuscript submissions: 30 November 2021

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Special Issue Editor

  • Guest Editor

    Lecturer dr. Constantin Munteanu, PhDE-MailWebsite

    President of the Romanian Association of Balneology. University of Medicine and Pharmacy "Gr. T. Popa", Iași, Romania

    Interests: Bioclimatology, Hydrothermotherapy, Physiology

  • Guest Editor

    Prof. Dr. Gelu OnoseE-MailWebsite

    Department of Physical and Rehabilitation Medicine, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania

    Interests: Physical and Rehabilitation Medicine & balneology, Neuro-Rehabilitation, Gerontology and geriatrics

  • Guest Editor

    Associate Prof. Dr. Mariana Rotariu, PhDE-MailWebsite

    University of Medicine and Pharmacy “ Gr. T. Popa ”, Vice president of the Romanian Association of Balneology, Iași, Romania

    Interests: IKinesiology, Rehabilitation, Psychomotor education

  • Guest Editor

    Assistant Prof. Dr. Gabriela Dogaru, PhDE-MailWebsite

    University of Medicine and Pharmacy “Iuliu Hațieganu”, Cluj-Napoca, Romania

    Interests: Neurological and Cardiovascular rehabilitation, Molecular and cellular medicine

  • Guest Editor

    Associate Prof. Dr. Elena Valentiana IONESCU, PhDE-MailWebsite

    “Ovidius” University of Constanța, Romania

    Interests: Bioclimatology, Hydrothermotherapy, and Medical rehabilitation

  • Guest Editor

    Assistant Prof. Dr. Cristina Daia, PhDE-MailWebsite

    Department of Physical and Rehabilitation Medicine, University of Medicine and Pharmacy ”Carol Davila”, Bucharest, Romania

    Interests: Rehabilitation medicine, Electromyography

Special Issue Information

Spinal cord injury affects more than 2,5 million people worldwide, with more than 130 000 new injuries reported annually. SCI is the result of aggression on the spinal cord, which totally or partially compromises its functions (motor, sensory, vegetative, reflex). SCI ends in 15% of cases with the victim's death before reaching the hospital. Also, mortality of about. 5% is registered at the level of specialized assistance centers capable of providing qualified, multidisciplinary assistance, while in non-specialized centers the mortality can be between 25-40%. As soon as a severe bonny spine lesion – with affecting the inner content represented by the spinal cord – occurs, the spinal cord usually enters a state of diminished/ abolished excitability, status consisting of altered reflex activity or even spinal shock. Transient inhibition of segments located caudally to the lesion is due to the sudden disappearance of the predominantly facilitating or excitatory influence of supraspinal centers, and at the same time to the local occurring damage mechanisms, thus clinically appearing (tetra-/ para-) paresis and/or flaccid paralysis. The duration of the spinal shock varies, a minimal activity – including with pathological patterns – may emerge within 3-4 days or only after 6-8 weeks (or never), with an average duration of 3-4 weeks, after which there are installed sequelae of the medullary lesion, while remaining local neurons below the lesion level become autonomous to the influences of the upper points. The degree of neurological injury and consequent deficit is determined by the extent and severity of the of above briefly mentioned factors’ action. Pain in patients with SCI dresses almost all possible variants: from acute pain, related to tissue trauma, to colic pain, caused by the presence of lithiasis, respectively to various types of headache, and especially neuropathic pain. The comprehensive, balanced, rehabilitation endeavors and related steps, comprises the application, for prophylactic and curative purposes of a variety of interventions, of: rehabilitation nursing, pharmacological and – very important – of physical/ kinesiological (also balneary – in the chronical stage), types.

In this special issue of Signa Vitae, dedicated to Spinal Cord Injury, we intend to underline general, of intimate level pathological and respectively, treatment mechanisms/ paradigms to undergo the current and future approaches in this domain, and particularly clinical and post research translational aspects, prone to improve the management of this lesions category, to better understand its emergency – including in the chronic/ rehabilitation period – requirements and needs for better practices. 


Spinal cord injury (SCI), Damage mechanisms, Primary and secondary medullary lesions, Neurorehabilitation, Neurorestoration

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Signa Viate is an international peer-reviewed open access journal published by MRE Press. As of January 2021, Signa Vitae will change to a bimonthly journal. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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Plan Papers (2 papers)

Polyuria and polydipsia associated with traumatic spinal cord injury: case series

Assist. prof. dr. Cristina Daia

Regenerative biotechnological interventions on Spinal Cord Injury - literature systematic review from the last five years

Prof. Gelu Onose

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