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Special Issue Title:

Spinal Cord Injury

Deadline for manuscript submissions: 31 March 2022

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Special Issue Editor

  • Guest Editor

    Associate Prof. Dr. Elena Valentiana IONESCU, PhDE-MailWebsite

    “Ovidius” University of Constanța, Romania

    Interests: Bioclimatology, Hydrothermotherapy, and Medical rehabilitation

  • Guest Editor

    Assistant Prof. Dr. Gabriela Dogaru, PhDE-MailWebsite

    University of Medicine and Pharmacy “Iuliu Hațieganu”, Cluj-Napoca, Romania

    Interests: Neurological and Cardiovascular rehabilitation, Molecular and cellular medicine

  • Guest Editor

    Assistant Prof. Dr. Cristina Daia, PhDE-MailWebsite

    Department of Physical and Rehabilitation Medicine, University of Medicine and Pharmacy ”Carol Davila”, Bucharest, Romania

    Interests: Rehabilitation medicine, Electromyography

  • Guest Editor

    Prof. Dr. Gelu OnoseE-MailWebsite

    Department of Physical and Rehabilitation Medicine, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania

    Interests: Physical and Rehabilitation Medicine & balneology, Neuro-Rehabilitation, Gerontology and geriatrics

  • Guest Editor

    Lecturer dr. Constantin Munteanu, PhDE-MailWebsite

    President of the Romanian Association of Balneology. University of Medicine and Pharmacy "Gr. T. Popa", Iași, Romania

    Interests: Bioclimatology, Hydrothermotherapy, Physiology

  • Guest Editor

    Associate Prof. Dr. Mariana Rotariu, PhDE-MailWebsite

    University of Medicine and Pharmacy “ Gr. T. Popa ”, Vice president of the Romanian Association of Balneology, Iași, Romania

    Interests: IKinesiology, Rehabilitation, Psychomotor education

Special Issue Information

Spinal cord injury affects more than 2,5 million people worldwide, with more than 130 000 new injuries reported annually. SCI is the result of aggression on the spinal cord, which totally or partially compromises its functions (motor, sensory, vegetative, reflex). SCI ends in 15% of cases with the victim's death before reaching the hospital. Also, mortality of about. 5% is registered at the level of specialized assistance centers capable of providing qualified, multidisciplinary assistance, while in non-specialized centers the mortality can be between 25-40%. As soon as a severe bonny spine lesion – with affecting the inner content represented by the spinal cord – occurs, the spinal cord usually enters a state of diminished/ abolished excitability, status consisting of altered reflex activity or even spinal shock. Transient inhibition of segments located caudally to the lesion is due to the sudden disappearance of the predominantly facilitating or excitatory influence of supraspinal centers, and at the same time to the local occurring damage mechanisms, thus clinically appearing (tetra-/ para-) paresis and/or flaccid paralysis. The duration of the spinal shock varies, a minimal activity – including with pathological patterns – may emerge within 3-4 days or only after 6-8 weeks (or never), with an average duration of 3-4 weeks, after which there are installed sequelae of the medullary lesion, while remaining local neurons below the lesion level become autonomous to the influences of the upper points. The degree of neurological injury and consequent deficit is determined by the extent and severity of the of above briefly mentioned factors’ action. Pain in patients with SCI dresses almost all possible variants: from acute pain, related to tissue trauma, to colic pain, caused by the presence of lithiasis, respectively to various types of headache, and especially neuropathic pain. The comprehensive, balanced, rehabilitation endeavors and related steps, comprises the application, for prophylactic and curative purposes of a variety of interventions, of: rehabilitation nursing, pharmacological and – very important – of physical/ kinesiological (also balneary – in the chronical stage), types.

In this special issue of Signa Vitae, dedicated to Spinal Cord Injury, we intend to underline general, of intimate level pathological and respectively, treatment mechanisms/ paradigms to undergo the current and future approaches in this domain, and particularly clinical and post research translational aspects, prone to improve the management of this lesions category, to better understand its emergency – including in the chronic/ rehabilitation period – requirements and needs for better practices. 


Spinal cord injury (SCI), Damage mechanisms, Primary and secondary medullary lesions, Neurorehabilitation, Neurorestoration

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. SignaVitae is an international peer-reviewed open access journal published by MRE Press. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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Published Papers (4 papers)

Open Access Special Issue

Particularities of clinical onset and favorable evolution towards functional neurorehabilitation in a very large post-acenocoumarol overdose hematoma (C7-T10) —a case report

Aura Spinu,Cristina Daia,Cristina Popescu,Ioana Andone,Theodora Ionescu,Ana Cristea,Mihai Baila,Costica Zamfir,Gelu Onose

DOI: 10.22514/sv.2021.112

(This article belongs to the Special Issue Spinal Cord Injury)

Abstract ( 2579 ) PDF (554.03 kB) ( 213 )

Open Access Special Issue

Pulmonary Rehabilitation throughout the Weaning from Mechanical Ventilation for Complete Cervical Spinal Cord Injury: A Case Report

Bin Zhang,Hongying Jiang,Chenxi Zhang,Yi Li,Zhanqi Zhao

DOI: 10.22514/sv.2020.16.0058

(This article belongs to the Special Issue Spinal Cord Injury)

Abstract ( 2551 ) PDF (1.12 MB) ( 233 )

Open Access Special Issue

Polydipsia-polyuria syndrome associated with traumatic spinal cord injury

Cristina Daia,Constantin Munteanu,Ioana Andone,Aura Spinu,Cristina Popescu,Corneliu Toader,Gelu Onose

DOI: 10.22514/sv.2021.104

(This article belongs to the Special Issue Spinal Cord Injury)

Abstract ( 3198 ) PDF (345.47 KB) ( 312 )

Open Access Special Issue

Is early surgical intervention effective for traumatic severe cervical spinal cord injury? A retrospective study secondary publication

Koji Yamamoto,Akinori Okuda,Naoki Maegawa,Hironobu Konishi,Keita Miyazaki,Yusuke Tada,Yohei Kogeichi,Keisuke Takano,Hideki Asai,Yasuyuki Kawai,Yasuyuki Urisono,Hideki Shigematsu,Kenji Kawamura,Hidetada Fukushima,Yasuhito Tanaka

DOI: 10.22514/sv.2021.256

(This article belongs to the Special Issue Spinal Cord Injury)

Abstract ( 2745 ) PDF (323.03 kB) ( 232 )

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