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Case Reports

Open Access Special Issue

Particularities of clinical onset and favorable evolution towards functional neurorehabilitation in a very large post-acenocoumarol overdose hematoma (C7-T10) —a case report

  • Aura Spinu1,2,†
  • Cristina Daia1,2,†
  • Cristina Popescu2,†
  • Ioana Andone1,2,†
  • Theodora Ionescu2,†
  • Ana Cristea2,†
  • Mihai Baila2,†
  • Costica Zamfir3,†
  • Gelu Onose1,2,†

1Physical and Rehabilitation Medicine Department, Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania

2The Neuromuscular Rehabilitation Clinic Division, Teaching Emergency Hospital "Bagdasar-Arseni" (TEHBA), 041915 Bucharest, Romania

3The Neurosurgery II Clinic Division, Teaching Emergency Hospital “Bagdasar-Arseni” (TEHBA), 041915 Bucharest, Romania

DOI: 10.22514/sv.2021.112 Vol.17,Issue 5,September 2021 pp.151-157

Submitted: 20 April 2021 Accepted: 18 May 2021

Published: 08 September 2021

(This article belongs to the Special Issue Spinal Cord Injury)

*Corresponding Author(s): Cristina Popescu E-mail:

† These authors contributed equally.


Introduction: The incidence of spontaneous spinal epidural hematoma is relatively rare and it may cause a spinal cord injury possibly associated with related severe disabling conditions: sensory-motor impairments, back pain, neurogenic bladder and bowel. The MRI is the golden standard diagnostic examination in patients suspected of spinal epidural hematoma. Still, such a spontaneous condition can be, not-seldom, asymptomatic.

Materials and methods: This paper presents the case of a 79-year-old male patient with permanent atrial fibrillation, treated with acenocoumarol, who was admitted, first in the General Surgery Clinic Division with rectal tenesmus and acute urinary retention and, subsequently developed a sudden onset of motor deficit, as presented in the body text. The patient was diagnosed with epidural hematoma (C7-T10) resulting in AIS/Frankel C paraplegia, with T10 neurological level. The positive and differential diagnoses concluded that the acenocoumarol overdose was the main etiopathogenic factor.

Results: The patient—being promptly transferred to the Spinal Neurosurgical Clinic Division—received conservative treatment, followed by a neuro-muscular rehabilitation program achieved in our Neuro-Rehabilitation Clinic Division, with mainly favorable outcomes: at discharge he was able to walk independently on short distances.

Conclusions: The clinical outcomes and quality of life of patients suffering from spinal epidural hematoma depend on the fast diagnosis and efficient acute neurosurgical/conservative treatment, followed by an appropriate rehabilitation program, including with medium and long term medical follow-up. This clinical case has received the Teaching Emergency Hospital “Bagdasar-Arseni” Bioethics Committee approval No. 27/1935-25.02.2021.


Spinal epidural hematoma; Neurorehabilitation; Acenocoumarol overdose; Neurologic deficit; Neurogenic bladder

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Aura Spinu,Cristina Daia,Cristina Popescu,Ioana Andone,Theodora Ionescu,Ana Cristea,Mihai Baila,Costica Zamfir,Gelu Onose. Particularities of clinical onset and favorable evolution towards functional neurorehabilitation in a very large post-acenocoumarol overdose hematoma (C7-T10) —a case report. Signa Vitae. 2021. 17(5);151-157.


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