Article Data

  • Views 2159
  • Dowloads 176

Original Research

Open Access Special Issue

The quality and continuity of systemic postoperative analgesia: a single center two-stage follow-up study

  • Jurate Gudaityte1,2,*,
  • Laura Jazokaite3,4
  • Brigita Saduikyte3,5
  • Danguole Ceslava Rugyte1,2

1Department of Anaesthesiology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania

2Department of Anaesthesiology, Hospital of Lithuanian University of Health Sciences Kaunas Clinics, 50161 Kaunas, Lithuania

3Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania

4Department of Intensive Care, Kaunas Hospital of the Lithuanian University of Health Sciences, 45130 Kaunas, Lithuania

5Department of ENT Surgery, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania

DOI: 10.22514/sv.2022.068 Vol.19,Issue 3,May 2023 pp.74-83

Submitted: 11 March 2022 Accepted: 29 April 2022

Published: 08 May 2023

(This article belongs to the Special Issue Opioid Free Analgesia: new concept, new trends)

*Corresponding Author(s): Jurate Gudaityte E-mail: jurate.gudaityte@kaunoklinikos.lt

Abstract

The aim of two prospective 1-month follow-up studies was to assess and compare the quality and continuity of postoperative systemic analgesia in Departments of Anaesthesiology and Surgery I and II, as well as adherence to prescribed plan of analgesia with respect to the effect of postoperative analgesia guidelines adopted in 2018. The studies included 94 (2016) and 80 (2018) patients who were operated under general anaesthesia, transferred to post-anaesthetic care unit (PACU), then to surgical wards and received systemic analgesia postoperatively. Comparison was based on adherence to postoperative analgesia plan during patient transfer. Recommendations for multimodal postoperative analgesia were given by the anaesthesiologist in 35.1% (ketoprofen + opioid) and 40.4% (paracetamol + opioid) in 2016 vs. 91.3% of cases in 2018, p < 0.001. Comparing 2016 to 2018, adherence to planned analgesia in PACU, % of cases was 35.1% vs. 92.5% for paracetamol (p < 0.001), 30.9% vs. 80% for ketoprofen (p < 0.001) and 75.5% vs. 72.5% for pethidine (p = 0.649). Adherence to planned analgesia after transfer to Department of Surgery I, % of cases was 3.3% vs. 80% for paracetamol (p < 0.001), 1.7% vs. 22% for ketoprofen (p < 0.001) and 61.7% vs. 20% for pethidine (p < 0.001). Adherence to planned analgesia after transfer to Department of Surgery II, % of cases was 0% vs. 10% for paracetamol (p = 0.059), 61.8% vs. 73.3% for ketoprofen (p = 0.325) and 29.4% vs. 13.3% for pethidine (p = 0.12), respectively. In conclusion, patients receive recommended systemic analgesia in PACU. Implementation of guidelines in Department of Surgery I resulted in 42% reduction of opioid and 76%increase of paracetamol use. Adherence to recommended analgesia in Department of Surgery II remains low.


Keywords

Postoperative; Analgesia; Surgery; Guidelines; Audit; Follow-up


Cite and Share

Jurate Gudaityte,Laura Jazokaite,Brigita Saduikyte,Danguole Ceslava Rugyte. The quality and continuity of systemic postoperative analgesia: a single center two-stage follow-up study. Signa Vitae. 2023. 19(3);74-83.

References

[1] Mariano ER, Miller B, Salinas FV. The expanding role of multimodal analgesia in acute perioperative pain manage-ment. Advances in Anes-thesia. 2013; 31: 119–136.

[2] Faust AC, Rajan P, Sheperd LA, Alvarez CA, McCorstin P, Doebele RL. Impact of an analgesia-based sedation protocol on mechanically ventilated patients in a medical intensive care unit. Anesthesia & Analgesia. 2016; 123: 903–909.

[3] Capdevila X. Pain management through multimodal analgesia in the ICU. ICU Management & Practice. 2019; 19: VI-VIII.

[4] Payen J, Genty C, Mimoz O, Mantz J, Bosson J, Chanques G. Prescribing nonopioids in mechanically ventilat-ed critically ill patients. Journal of Critical Care. 2013; 28: 534.e7–e12.

[5] Jin F, Chung F. Multimodal analgesia for postoperative pain control. Journal of Clinical Anesthesia. 2001; 13: 524–539.

[6] Jazokaite L, Gudaityte J, Saduikyte B. Continuity of postoperative analgesia for postsurgical pain control, lithuanian university of health sciences kaunas clinics: audit of 2016 vs. 2018. European Journal of Anaesthesiology. 2020; 37: 254.

[7] Brinck ECV, Virtanen T, Mäkelä S, Soini V, Hynninen V-V, Mulo J, et al. S- ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: a randomized, double-blind, placebo-controlled clinical trial. PLoS ONE. 2021; 16: e0252626.

[8] Schiavenato M, Craig KD. Pain assessment as a social transaction. The Clinical Journal of Pain. 2010; 26: 667–676.

[9] van Dijk JFM, van Wijck AJM, Kappen TH, Peelen LM, Kalkman CJ, Schuurmans MJ. Postoperative pain assessment based on numeric ratings is not the same for patients and professionals: a cross-sectional study. International Journal of Nursing Studies. 2012; 49: 65–71.

[10] von Baeyer CL. Children’s self-report of pain intensity: what we know, where we are headed. Pain Research and Management. 2009; 14: 39–45.

[11] Twycross A, Voepel-Lewis T, Vincent C, Franck LS, von Baeyer CL. A debate on the proposition that self-report is the gold standard in assessment of pediatric pain intensity. The Clinical Journal of Pain. 2015; 31: 707–712.

[12] Voepel-Lewis T. How reliable are ‘valid and reliable’ pain scores in the pediatric clinical setting? Pain Management. 2013; 3: 343–350.

[13] Huguet A, Stinson JN, McGrath PJ. Measurement of self-reported pain intensity in children and adolescents. Journal of Psychosomatic Research. 2010; 68: 329–336.

[14] Kozlowski LJ, Kost-Byerly S, Colantuoni E, Thompson CB, Vasquenza KJ, Rothman SK, et al. Pain prevalence, intensity, assessment and management in a hospitalized pediatric population. Pain Management Nursing. 2014; 15: 22–35.

[15] Franck LS, Bruce E. Putting pain assessment into practice: why is it so painful? Pain Research and Management. 2009; 14: 13–20.

[16] Zisk-Rony RY, Lev J, Haviv H. Nurses’ report of in-hospital pediatric pain assessment: examining challenges and perspectives. Pain Management Nursing. 2015; 16: 112–120.

[17] Cravero JP, Agarwal R, Berde C, Birmingham P, Cote CJ, Galinkin J, et al. The society of pediatric anesthesia recommendations for the use of opioids in children during the perioperative period. Pediatric Anesthesia. 2019; 29: 547–571.

[18] Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud PC, et al. Why don’t physicians fol-low clinical practice guidelines? JAMA. 1999; 282: 1458.

[19] Emond YEJJM, Wolff AP, Peters YAS, Bloo GJA, Westert GP, DamenJ, et al. Reducing work pressure and IT problems and facilitating IT integration and audit & feedback help adherence to perioperative safety guide-lines: a survey among 95 perioperative professionals. Implementation Science Communications. 2020; 1: 49.

[20] van Gulik L, Ahlers SJGM, Bruins P, Tibboel D, Knibbe CAJ, van Dijk M. Adherence to all steps of a pain management protocol in intensive care patients after cardiac surgery is hard to achieve. Pain Research and Management. 2017; 2017: 1–7.

[21] Porreca F, Ossipov MH. Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options. Pain Medicine. 2009; 10: 654–662.

[22] Shim H, Gan TJ. Side effect profiles of different opioids in the perioperative setting: are they different and can we reduce them? British Journal of Anaesthesia. 2019; 123: 266–268.

[23] Takkouche B, Montes-Martínez A, Gill SS, Etminan M. Psychotropic medications and the risk of fracture: a meta-analysis. Drug Safety. 2007; 30: 171–184.

[24] Clegg A, Young JB. Which medications to avoid in people at risk of delirium: a systematic review. Age and Ageing. 2011; 40: 23–29.

[25] Solomon DH. The comparative safety of analgesics in older adults with arthritis. Archives of Internal Medicine. 2010; 170: 1968.

[26] Dublin S, Walker RL, Jackson ML, Nelson JC, Weiss NS, Korff M, et al. Use of opioids or benzodiaz-epines and risk of pneumonia in older adults: a population-based case-control Study. Journal of the American Geriatrics Society. 2011; 59: 1899–1907.

[27] O’Neil CK, Hanlon JT, Marcum ZA. Adverse effects of analgesics commonly used by older adults with osteo-arthritis: focus on non-opioid and opioid analgesics. The American Journal of Geriatric Pharmacotherapy. 2012; 10: 331–342.

[28] Kantor TG. Ketoprofen: a review of its pharmacologic and clinical properties. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 1986; 6: 93–102.

[29] Mattia A, Coluzzi F. What anesthesiologists should know about paracetamol (acetaminophen). Minerva Anestesiologica. 2009; 75: 644–653.

[30] The Council of Economic Advisers. The underestimated cost of the opioid crisis. 2016 National Survey on Drug Use and Health, Mortality in the United States. 2016 NCHS Data Brief No 293. CEA Report. December 2017. Available at: https://www.whitehouse.gov/cea (Accessed: 30 April 2020).

[31] Nordquist D, Halaszynski TM. Perioperative multimodal anesthesia using regional techniques in the aging surgical patient. Pain Research and Treatment. 2014; 2014: 1–13.

[33] Brady R, Ventham N, Roberts D, Graham C, Daniel T. Open transversus abdominis plane block and analgesic requirements in patients following right hemicolectomy. The Annals of the Royal College of Surgeons of England. 2012; 94: 327–330.

[34] Koh IJ, Kim MS, Sohn S, Song KY, Choi NY, In Y. Duloxetine reduces pain and improves quality of recovery following total knee arthroplasty in centrally sensitized patients. Journal of Bone and Joint Surgery. 2019; 101: 64–73.

[35] Weibel S, Jokinen J, Pace NL, Schnabel A, Hollmann MW, Hahnenkamp K, et al. Efficacy and safety of intravenous lidocaine for postoperative analgesia and recovery after surgery: a systematic review with trial sequen-tial analysis. British Journal of Anaesthesia. 2016; 116:770–783.

[36] Caumo W, Levandovski R, Hidalgo MPL. Preoperative anxiolytic effect of melatonin and clonidine on post-operative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, random-ized, placebo-controlled study. The Journal of Pain. 2009; 10: 100–108.

[37] Choi S, Rampersaud YR, Chan VWS, Persaud O, Koshkin A, Tumber P, et al. The addition of epidural local anesthetic to systemic multimodal analgesia following lumbar spinal fusion: a randomized controlled trial. Canadian Journal of Anesthesia/Journal Canadien D’AnesthéSie. 2014; 61: 330–339.

[38] Kandarian BS, Elkassabany NM, Tamboli M, Mariano ER. Updates on multimodal analgesia and regional anesthesia for total knee arthroplasty patients. Best Practice & Research Clinical Anaesthesiology. 2019; 33: 111–123.

[39] Parvizi J, Bloomfield MR. Multimodal pain management in orthopedics: implications for joint arthroplasty surgery. Orthopedics. 2013; 36: 7–14.

[40] Jamdade PT, Porwal A, Shinde JV, Erram SS, Kamat VV, Karmarkar PS, et al. Efficacy and tolerability of intramuscular dexketoprofen in postoperative pain management following hernia repair surgery. Anesthesiology Research and Practice. 2011; 2011: 1–4.

[41] Andersen LJ, Poulsen T, Krogh B, Nielsen T. Postoperative analgesia in total hip arthroplasty: a randomized double-blinded, placebo-controlled study on peroperative and postoperative ropivacaine, ketorolac, and adrenaline wound infiltration. Acta Orthopaedica. 2007; 78: 187–192.

[42] Busch CA, Whitehouse MR, Shore BJ, MacDonald SJ, McCalden RW, Bourne RB. The efficacy of periarticu-lar multimodal drug injection in total hip arthroplasty. Clinical Orthopaedics and Related Research. 2010; 468: 2152–2159.

[43] Moore A, Crossley A, Ng B, Phillips L, Sancak Ö, Rainsford KD. Use of multicriteria decision analysis for assessing the benefit and risk of over-the-counter analgesics. Journal of Pharmacy and Pharmacology. 2017; 69: 1364–1373.

[32] Werawatganon T, Charuluxanun S. Patient controlled intravenous opioid analgesia versus continuous epi-dural analgesia for pain after intra-abdominal surgery. Cochrane Database of Systematic Reviews. 2005; CD004088.


Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.0 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Conferences

Top