Article Data

  • Views 687
  • Dowloads 161

Original Research

Open Access

Cirsilineol reduces inflammation and apoptosis in an in vitro model of acute pancreatitis

  • Wanqiong Zheng1,*,
  • Ye Tian2
  • Yiming Zhang1
  • Binnan Li1

1General Surgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, 325000 Wenzhou, Zhejiang, China

2Department of Oncology, Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, 712000 Xianyang, Shaanxi, China

DOI: 10.22514/sv.2024.111 Vol.20,Issue 9,September 2024 pp.56-62

Submitted: 28 June 2024 Accepted: 14 August 2024

Published: 08 September 2024

*Corresponding Author(s): Wanqiong Zheng E-mail: zwq5171717@163.com

Abstract

Acute pancreatitis (AP) is a severe inflammatory disorder for which effective treatments are currently lacking. Cirsilineol (CSL), a flavonoid derived from Artemisia plants, is recognized for its potent anti-inflammation and antioxidant characteristics. The mechanisms underlying AP and potential therapeutic agents remain unknown. This study investigates the effects of CSL on AP and delves into its underlying mechanism. Our results indicate that CSL significantly improved cell viability in AR42J pancreatic acinar cells and influenced the levels of pro-inflammatory cytokines. Furthermore, CSL markedly decreased apoptosis markers and inhibited the Nuclear Factor kappa-B (NF-κB) activation by reducing phosphorylation of p65 and inhibitor of NF-κB alpha (IκBα). These findings underscore the powerful anti-inflammatory and anti-apoptotic properties of CSL, acting through the NF-κB pathway, indicating its promise as a therapeutic option for AP.


Keywords

Cirsilineol; Acute pancreatitis; Inflammation; Apoptosis; NF-κB signaling


Cite and Share

Wanqiong Zheng,Ye Tian,Yiming Zhang,Binnan Li. Cirsilineol reduces inflammation and apoptosis in an in vitro model of acute pancreatitis. Signa Vitae. 2024. 20(9);56-62.

References

[1] Mederos MA, Reber HA, Girgis MD. Acute pancreatitis: a review. JAMA. 2021; 325: 382–390.

[2] Szatmary P, Grammatikopoulos T, Cai W, Huang W, Mukherjee R, Halloran C, et al. Acute pancreatitis: diagnosis and treatment. Drugs. 2022; 82: 1251–1276.

[3] Lankisch PG, Apte M, Banks PA. Acute pancreatitis. The Lancet. 2015; 386: 85–96.

[4] Lee PJ, Papachristou GI. New insights into acute pancreatitis. Nature Reviews Gastroenterology & Hepatology. 2019; 16: 479–496.

[5] Patel DK. Health benefits, therapeutic applications, and recent advances of cirsilineol in the medicine: potential bioactive natural flavonoids of genus Artemisia. Endocrine, Metabolic & Immune Disorders Drug Targets. 2023; 23: 894–907.

[6] Kim C, Kim GO, Bae JS. Cirsilineol treatment attenuates PM2.5-induced lung injury in mice. International Journal of Molecular Sciences. 2022; 23: 13948.

[7] Wahab S, Alsayari A, Muhsinah AB, Ahmad I, Hussain MS, Mallick J. Cirsilineol inhibits the proliferation of human prostate cancer cells by inducing reactive oxygen species (ROS)-mediated apoptosis. Evidence-Based Complementary and Alternative Medicine. 2022; 2022: 7975664.

[8] Wang C, Zeng R, Li Y, He R. Cirsilineol inhibits RANKL-induced osteoclast activity and ovariectomy-induced bone loss via NF-kb/ERK/p38 signaling pathways. Chinese Medicine. 2024; 19: 69.

[9] Kim GO, Heo JB, Park DH, Song GY, Bae JS. Antiplatelet aggregation properties of cirsilineol: a novel inhibitor of blood coagulation factor Xa. Pharmaceuticals. 2023; 16: 588.

[10] Wang X, Qian J, Meng Y, Wang P, Cheng R, Zhou G, et al. Salidroside ameliorates severe acute pancreatitis-induced cell injury and pyroptosis by inactivating Akt/NF-kB and caspase-3/GSDME pathways. Heliyon. 2023; 9: e13225.

[11] Zhang P, Yin X, Wang X, Wang J, Na G, Ирина Павловна К. Paeonol protects against acute pancreatitis by Nrf2 and NF-kB pathways in mice. Journal of Pharmacy and Pharmacology. 2022; 74: 1618–1628.

[12] Kim GO, Park DH, Bae JS. Protective effects of cirsilineol against lipopolysaccharide-induced inflammation; insights into HO-1, COX-2, and iNOS modulation. International Journal of Molecular Sciences. 2023; 24: 8537.

[13] Liu Y, Cui H, Mei C, Cui M, He Q, Wang Q, et al. Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1a/HO-1 mediated ferroptosis. Cell Death & Disease. 2023; 14: 694.

[14] Nagy-Penzes M, Hajnady Z, Regdon Z, Demény MÁ, Kovács K, El-Hamoly T, et al. Tricetin reduces inflammation and acinar cell injury in cerulein-induced acute pancreatitis: the role of oxidative stress-induced DNA damage signaling. Biomedicines. 2022; 10: 1371.

[15] Guangzhen Zhao JJ. HOMER1A restores sevoflurane-induced cognitive dysfunction by regulating microglia’s activation through activating the AMPK/TXNIP axis. Signa Vitae. 2023; 19: 202–212.

[16] Luan Y, Luan Y, Jiao Y, Liu H, Huang Z, Feng Q, et al. Broadening horizons: exploring mtDAMPs as a mechanism and potential intervention target in cardiovascular diseases. To be published in Aging and Disease. 2023. [Preprint].

[17] Lan WP, Guo W, Zhou X, Li Z. Research trends on traditional Chinese medicine and acute pancreatitis: a bibliometric analysis from 2007 to mid-2023. Heliyon. 2024; 10: e25659.

[18] Li L, Liu Q, Le C, Zhang H, Liu W, Gu Y, et al. Toll-like receptor 2 deficiency alleviates acute pancreatitis by inactivating the NF-kB/NLRP3 pathway. International Immunopharmacology. 2023; 121: 110547.

[19] Pan C, Zhang C, Li Y, Cao J, Liang S, Fang H, et al. Studies related to the involvement of EsA in improving intestinal inflammation in acute pancreatitis via the NF-kB pathway. Mediators of Inflammation. 2024; 2024: 9078794.

[20] Ali BM, Al-Mokaddem AK, Selim H, Alherz FA, Saleh A, Hamdan AME, et al. Pinocembrin’s protective effect against acute pancreatitis in a rat model: the correlation between TLR4/NF-kB/NLRP3 and miR-34a-5p/SIRT1/Nrf2/HO-1 pathways. Biomedicine & Pharmacotherapy. 2024; 176: 116854.


Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.3 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Conferences

Top