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Original Research

Open Access

Predictive value of inflammatory indices in acute cholecystitis: a retrospective study of gallstone detection and outcome assessment

  • Mehmet Göktuğ Efgan1,*,
  • Ejder Saylav Bora1
  • Semih Musa Coşkun1
  • Süleyman Kırık1
  • Ahmet Kayalı1

1Izmir Katip Çelebi University Department of Emergency Medicine, 35100 Izmir, Turkey

DOI: 10.22514/sv.2024.134

Submitted: 11 July 2024 Accepted: 14 August 2024

Online publish date: 12 October 2024

*Corresponding Author(s): Mehmet Göktuğ Efgan E-mail: mehmetgoktug.efgan@ikcu.edu.tr

Abstract

This retrospective observational study investigates the predictive value of inflammatory indices Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR) and Systemic Inflammatory Index (SII) for detecting gallstones and forecasting outcomes in patients with acute cholecystitis (AC). Conducted from 01 September 2022, to 01 September 2023, the research involved patients aged 18 and older diagnosed with AC in an emergency department, excluding those with overlapping pathologies or insufficient data. The study employed hemogram-based indices to explore their correlation with the presence of gallstones and the severity of AC, assessing outcomes such as hospitalization duration and the necessity for surgical intervention. Findings demonstrated that high NLR and SII values significantly correlated with severe outcomes and increased hospitalization rates, while SII exhibited the highest accuracy in predicting mortality. Moreover, the study uniquely identified the Systemic Inflammatory Response Index (SIRI) as a significant marker for gallstone presence. In conclusion, inflammatory indices like NLR, PLR and SII can be practical prognostic tools in managing AC, potentially guiding clinical decisions regarding immediate surgical needs and overall patient management. This suggests a broader application for these indices in emergency and surgical settings, improving diagnostic accuracy and treatment strategies.


Keywords

Acute cholecystitis; Gallstones; Systemic inflammatory index; Systemic inflammatory response index; Neutrophil-lymphocyte ratio; Platelet-lymphocyte ratio


Cite and Share

Mehmet Göktuğ Efgan,Ejder Saylav Bora,Semih Musa Coşkun,Süleyman Kırık,Ahmet Kayalı. Predictive value of inflammatory indices in acute cholecystitis: a retrospective study of gallstone detection and outcome assessment. Signa Vitae. 2024.doi:10.22514/sv.2024.134.

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