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Special Issue Title:

Next-generation Metabolomics in Critical Care Medicine

Deadline for manuscript submissions: 31 December 2021

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Special Issue Editor

  • Guest Editor

    Dr. Kefeng LiE-MailWebsite

    School of Medicine, University of California, San Diego, USA

    Interests: Metabolomics and its application in critical illness

  • Guest Editor

    Dr. Jing WangE-MailWebsite

    Department of Intensive Care Unit, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Shandong, China

    Interests: Critical care medicine, Metabolomics, Sepsis

Special Issue Information

Twenty-first–century medicine is entering into the omics era. Metabolomics aims to measure the small molecules (metabolites) within cells, biofluids, or tissues using various analytical techniques, at the same time reflecting genome, transcriptome, or proteome changes. Next-generation metabolomic approaches globally measure hundreds and thousands of metabolites (such as amino acids, nucleotides, and lipids) in a given time. The metabolomic analysis allows us to identify and quantify the metabolic profile of any cell or tissues dynamically, detailed investigate biological pathways and provide information about the communications between different organ systems. Therefore, metabolomics offers strategic advantages for the elucidation of the new roles of metabolism in disease, the identification of biomarkers, and the development of new therapeutics.

The intensive care unit is an uncharted frontier. Emergency illness often causes significant disruptions in metabolic homeostasis, characterized by organ and system function failure, i.e., pathological changes occur at the system, organ, cellular and subcellular levels. The most prominent metabolic violations are observed in septic patients. Therefore, assessing the metabolome could have major applications in critical care medicine for disease diagnosis, prognosis evaluation, and development of novel therapeutic strategies.

In this special issue of the journal Signa Vitae, we aim to provide our current understanding of emergency medicine using high throughput omics techniques, primarily metabolomics. We welcome submissions covering the following subtopics:

·Metabolomics and lipidomics to understand the pathogenesis of various critical diseases including but not limited to sepsis, acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and organ failure.

·Differential diagnosis of various critical diseases by omics techniques.

·Using metabolomics in predicting the prognosis of critical illness.

·Development of novel therapeutic strategies in emergency medicine using metabolomics.

·The integration of multi-omics approaches with metabolomics as a part is also welcome.

We accept original articles, review articles, short reports, meta-analysis, and letters to the editor. The clinical utility of metabolomics in emergency medicine is just beginning to emerge. We sincerely invite you to submit your valuable work to this special issue, and your contribution will improve the practice of emergency medicine and, ultimately, save lives. We commit to providing rigorous, constructive, efficient, and transparent peer review. The deadline for submission of this special issue will be on 31 August 2021.


Omics, Metabolomics, Lipidomics, Critical Care Medicine, Biomarkers, Prognosis

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Signa Viate is an international peer-reviewed open access journal published by MRE Press. As of January 2021, Signa Vitae will change to a bimonthly journal. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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Published Papers (2 papers)

Open Access Special Issue

Recent application of metabolomics in the diagnosis, pathogenesis, treatment, and prognosis of sepsis

Xiaofei Li,Jing Wang

Online publish date: 16 December 2021

DOI: 10.22514/sv.2021.246

(This article belongs to the Special Issue Next-generation Metabolomics in Critical Care Medicine)

Abstract ( 533 ) PDF (6.61 MB) ( 169 ) Full Text

Open Access Special Issue

The role of metabolomics in myocardial infarction: a recent mini-review

Xuguang Miao,Cui Song,Pu Zhen

Online publish date: 30 December 2021

DOI: 10.22514/sv.2021.252

(This article belongs to the Special Issue Next-generation Metabolomics in Critical Care Medicine)

Abstract ( 443 ) PDF (2.04 MB) ( 150 ) Full Text

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