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Special Issue Title:

Pathophysiology of Sepsis

Deadline for manuscript submissions: 31 August 2021

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Special Issue Editor

  • Guest Editor

    Dr. Susan F. FitzpatrickE-MailWebsite

    Scientific Researcher at University College Dublin, Belfield, Dublin 4, Ireland

    Interests: Hypoxia and inflammation, Inflammatory bowel disease, Sepsis, Innate immune, Clinical symptomology

Special Issue Information

Sepsis defined as a dysregulated host response to infection leading to organ failure is a global health crisis. Worldwide approximately 49 million incidents of sepsis and 11 million deaths related to sepsis were reported in 2017. Sepsis is not disappearing; in fact, the number of patients with sepsis is increasing worldwide, due to the development of antibiotic resistant bacteria, emergence of novel infectious diseases e.g. COVID-19 and increased longevity these numbers are dramatically increasing each year. Thus, a coordinated global effort is urgently needed to tackle this crisis.

The pathophysiology of sepsis is complex. Previously, it was believed that sepsis was simply an exaggerated, hyperinflammatory response with patients dying from inflammation-induced organ injury. However, data over the last two decades has shown that the manifestation of sepsis can no longer be attributed only to the infectious agent and the immune response it engenders, but is also due to dysregulated coagulation, cellular dysfunction, immunosuppression, altered metabolism and organ dysfunction. Despite these advances in our understanding we still lack a full understanding of the pathogenesis of sepsis, and many questions remain. For instance, what is the mechanism for the initiation, maintenance, and termination of sepsis? What is the underlying mechanism of sepsis causing cellular and subcellular dysfunction? How does cellular dysfunction cause organ failure? What are the mechanisms contributing to dysregulated coagulation and metabolism? Are septic patients hyperinflammatory or immunocompromised?

In this special issue we aim to bring together Original Research, Reviews, Mini-Reviews, Perspective, Protocols, Case Report articles to enhance our knowledge of the pathophysiology of sepsis. In doing so we hope to identify new avenues for healthcare intervention and to accelerate improved diagnosis and treatment for sepsis. 


Sepsis, Hyperinflammatory response, Dysregulated coagulation, Cellular dysfunction, Immunosuppression, Metabolism, Organ dysfunction, Immunocompromise

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Signa Viate is an international peer-reviewed open access journal published by MRE Press. As of January 2021, Signa Vitae will change to a bimonthly journal. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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Published Papers (2 papers)

Open Access Special Issue

Establishment of a Linear Correlation Model of Central Venous Blood Oxygen Saturation and Lactate in Sepsis

Songchang Shi,Xiaobin Pan,Wei Lin,Chao Wu,Mei Ye,Yingfeng Zhuang,Jian Lin,Xincai Wang,Lihui Zhang,Shujuan Zhang,Hangwei Feng,Long Huang,Songjing Shi,Xingsheng Lin

DOI: 10.22514/sv.2020.16.0064

(This article belongs to the Special Issue Pathophysiology of Sepsis)

Abstract ( 1050 ) PDF (2.34 MB) ( 177 ) Full Text

Open Access Special Issue

Use of quick sequential organ failure assessment score-based sepsis clinical decision support system may be helpful to predict sepsis development

Youn-Jung Kim,Jae-Ho Lee,Sang-Wook Lee,Won Young Kim

DOI: 10.22514/sv.2021.082

(This article belongs to the Special Issue Pathophysiology of Sepsis)

Abstract ( 995 ) PDF (412.81 kB) ( 194 ) Full Text

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