Special Issues

Author instructions

Manuscript Submission Overview

Article types

Signa Vitae is an international peer-reviewed open access journal designed to publish papers covering adult, pediatric and neonatal intensive care, as well as anesthesia and emergency medicine. The journal’s intention is to be practice-oriented, and therefore Signa Vitae for publications accepts review articles, original articles, short reports, case reports and letters to the editor. Full texts of all articles, published so far, can be downloaded for free from our website.

The Editor-in-Chief and members of the Journal's Editorial Board and independent experts, will review most manuscripts submitted to SV. However, the Editor-in-Chief and the Editors reserve the right to reject a manuscript without conducting an in-depth review if they feel that the manuscript is "out of scope" or it does not meet the minimal acceptance criteria for publication in SV.

We accept 12 types of article as follows:

Original Research

This is the most common type of journal manuscript. It may be called an Original Article, Research Article, or just Article, depending on the journal. The Original Research format is suitable for many different fields and different types of studies. It includes full Introduction, Methods, Results, and Discussion sections, no less than 5 journal pages (about 5,000 words). Complete research findings where aims/hypotheses are fully addressed.


This is a comprehensive overview of a specific hot topic aligned with addressing the aims and hypothesis through the literature. They are often written by leaders in a particular discipline after invitation from the editors of a journal. Reviews are often widely read (for example, by researchers looking for a full introduction to a field) and highly cited. Reviews commonly cite approximately 100 primary research articles.


Mini-Reviews are summaries of recent insights in specific research areas within the scope of Journal. All Mini-Reviews should be about 5000 words and should not include more than 100 references.

Systematic Review

Systematic reviews are a type of literature review that uses systematic methods to collect secondary data, critically appraise research studies, and synthesize findings qualitatively or quantitatively.

Short Communication

Preliminary research addressing an important area of research. These papers communicate brief reports of data from original research that editors believe will be interesting to many researchers, and that will likely stimulate further research in the field. A short communication may be called a brief communication, brief report.

Case Report

In medicine, a case report is a detailed report of the symptoms, signs, diagnosis, treatment, and follow-up of an individual patient. Case reports may contain a demographic profile of the patient, but usually describe an unusual or novel occurrence. Some case reports also contain a literature review of other reported cases. Case reports are professional narratives that provide feedback on clinical practice guidelines and offer a framework for early signals of effectiveness, adverse events, and cost. They can be shared for medical, scientific, or educational purposes.

Letter to the Editor

We welcome readers to submit formal comments on the content of articles published in Signa Vitae. Such comments should provide constructive scientific remarks. Readers may submit these comments as a Letter to the Editor, which should be concise, no more than 500 words, and we will transmit them to the author(s) of the commented-upon paper for their optional reply.


Commentaries are short articles usually around 1000-1,500 words long that draw attention to or present a criticism of a previously published article, book, or report, explaining why it interested them and how it might be illuminating for readers.

Rapid Report

Short papers falling under 5000 words but not preliminary research.

News and Views

News and Views inform readers of the latest scientific advances in Anaesthesia, Intensive Care and Emergency Medicine, reported in Signa Vitae or elsewhere. Although prospective authors are welcome to make proposals, unsolicited contributions will not usually be considered. News and Views are not peer reviewed but will be properly edited in consultation with the author.


These are usually non-peer-reviewed texts used to announce the launch of a new section, a new Editor-in-Chief, a Special Issue, or an invited editorial, etc. Editorial should not report primary research or secondary analysis of primary research, although must provide a Conflict of Interest statement. Such manuscripts should be assessed by the Editor(s) if the topic is in the area of expertise of the Editor(s); if the topic is not in area of expertise of the Editor(s), such manuscripts should be assessed by at least one independent expert reviewer or Editorial Board Member.

Meeting Report

Meeting report also known as meeting abstract details the significant advances in a particular field presented and discussed at the meeting. Meeting reports aim to deliver more in-depth information about a particular topic given on a meeting.

Organization of the Manuscript

Manuscript typeface format

☆ Times New Roman. Font size 12. Single line spacing. Alignment Justified.

☆ The first line indents 2 characters of a new paragraph.

☆ Sub-headings and general headings should be presented in lower case letters (not capitals).

☆ Use British English or American English spellings throughout your manuscript, but not both.

☆ Do not use page breaks in your manuscript.

☆ Divide your article into clearly defined and numbered sections. Subsections should be numbered 1.1 (then 1.1.1, 1.1.2, ...), 1.2, etc. (the abstract is not included in section numbering). Use this numbering also for internal cross-referencing: do not just refer to 'the text'. Any subsection may be given a brief heading.

Please note: editable files are required for processing in production. If your manuscript contains any non-editable files (such as PDFs) you will be required to re-submit an editable file when you submit your revised manuscript, or after editorial acceptance in case no revision is necessary.

General considerations

Equations and Symbols

Manuscripts with many mathematical characters and equations should be prepared using MathType version 6.0 or higher or word-processing tools such as Word’s Equation Editor.

Abbreviations and Units

IF abbreviations appear more than once, the definition should be provided once, and then subsequently used throughout the text. Symbols for physical units should be restricted to System International units (SI) should be used without definition. Generic names of drugs and pesticides are preferred; if trade names are used, the generic name should be given at first mention. The doses of the drugs should be given as unit weight/unit body weight, e.g. mmol/kg or mg/kg. Genus and species names should be in italics.

Please use the standard mathematical notation for formulae, symbols, etc.

Always use a leading zero (0) before decimal points: 0.5 NOT .5.

Decimal points should use a full stop/period (.) NOT a comma (,).

A space should be inserted before measurement units: 132 bp NOT 132bp, 5 mm NOT 5mm, 1 h NOT 1h.

Symbols for genes should be italicized (p53), whereas symbols for proteins are not italicized (p53). Gene names that are written out in full are not italicized (tumor protein 53).


Original data: The editors reserve the right to request authors to provide any original, unprocessed data in the submission, review, or publication process, including after publication.

Image manipulation: All images in manuscripts accepted for publication will be production delays or revocation of acceptance which inconsistent with the following guidelines:

Do not enhance, occlude, move, remove or introduce specific features in the image

Do not combination figures using images taken from different parts of the same gel or from different gels.

Do not arise image duplication in submission, including retroflexion. color balance.

File format


For vector graphics, the preferred format is EPS, Vector graphics containing fonts must have the fonts embedded in the files.

TIFF without layers and preferably using Lempel-Ziv-Welch (LZW) compression as it does not reduce image quality.

JPEG (only if originally saved at the highest quality).


Images imported or copy pasted into Word or PowerPoint.

BMP, GIF, PCT, PNG or low quality JPEG files originally saved at low quality.


Image size is measured in centimeters or inches.

Create your figures at the size (width) at which they will be printed:

* 8.00 cm (3.15 in) wide for a single-column figure

* 17.00 cm (6.70 in) maximum for a double-column (full page width) figure

* Maximum height 20.00 cm (7.87 in)

Empty white space surrounding a figure should NOT be included when calculating image size.

Images should, therefore, be cropped (cut) as close to the outside edges of the figure as possible.


Minimum resolution for all figures is 300 dpi. For figures that contain both photographs and line art or text, 600 dpi is highly recommended. Figures containing only black and white elements (line art, no color, and no gray) should be 1,000 dpi. Maximum figure size is 7 in wide x 9 in high (17.5 x 22.8 cm) at the correct resolution.

Note: Resolution settings in many software programs (including vector programs such as Illustrator) default to low resolution (72 dpi) when placing images. Be certain to set resolution prior to beginning your figure layout.

Color mode

Use RGB as this will offer the best reproduction of your data in the final PDF version of your article on screen. CMYK mode is also acceptable. Fluorescence images must be submitted for publication in color. Black and white figures and line art: grey scale mode or RGB mode.

Combination figures with color images and line art: RGB mode.

Figure name

Figures are cited sequentially in the text using Arabic numerals (for example, Fig. 1).

Type appearing within figures (axis labels, for example) is in Arial or a similar typeface and is of sufficient size and contrast to retain clarity if reduced in size. Avoid use of bold type in figure labels.

Figure labels

Labels should be sized in proportion to the image, sharp, and clearly legible.

Type appearing within figures (axis labels, for example) is in Arial or a similar typeface and is of sufficient size and contrast to retain clarity if reduced in size. Avoid use of bold type in figure labels.

Figures may be divided into separate sections. Each section may be saved as a separate file (clearly indicated in file name) or included together in one file (with parts clearly labeled). Separate parts of a figure should be labeled using just A, B, C, NOT a, b, c, 1A, 1B, 1C. Place A, B, C to the top left of each section of the figure. And each section of the figure should be well-arranged.

The labels should be of the same font and size in all figures. Also, the numbering should be of the same font and size in all figures.

Labels should be evenly spaced and aligned, easy to see (including exponential numbers around figure axes), and NOT faded, broken, or distorted by JPG compression artifact.

If any magnification is used in the photographs, indicate this by using scale bars within the figures themselves.

Avoid gratuitous use of color for decorative effect, boxes around graphs and figures, and small type and symbols on large graphs; avoid pairing red and green in graphs to ensure legibility for color-blind readers. Whenever possible, do not place labels over any part of a color figure. Do not include tabular material within figures.

Do NOT use light grey color lines or labels.

There must be strong contrast between labels and their background (e.g., labels placed over shaded bar graphs should be in a color that stands out against the shading, NOT blend in with it). Whenever possible, labels should be placed in black font on a white background. Consider using a black label with a white stroke applied to create contrast.

The first letter of each phrase, NOT each word, should be capitalized [e.g., ‘Overall survival (months)’ not ‘Overall Survival (Months)’ and not ‘overall survival (months)]’.

Do not include titles or captions within your illustrations.


Please submit tables as editable text and not as images. Tables can be placed either next to the relevant text in the article, or on separate page(s) at the end. The data presented in tables do not duplicate results described elsewhere in the article. Tables with sections (for example, Table 1A, 1B, 1C) are not acceptable. For each table, please supply a table caption (title) explaining the contents of the table. Place any table notes below the table body. If bold or italic font is used within a table to indicate some feature of the data, please give an explanation of its usage in the legend. All abbreviations within a table must be defined in the table legend or footnotes. Footnotes should be listed with superscript lowercase letters, beginning with “a.” Footnotes may not be listed with numbers or symbols.

Manuscript construct

Manuscripts must include the following sections in the order listed

Front matter: Title Page (Title, Full names, email address and affiliations including postal codes of all authors, Corresponding author and corresponding email address, Conflict of interest statement, Acknowledgments)

Body: Abstract (The abstract should be no less than 40 words and no more than 300 words), Keywords, Introduction, Materials and Methods, Results, Discussion, Conclusions

Back matter: Ethics approval and consent to participate, Authors’ Contributions References, Figure Legends, Supplementary materials

Front matter

Title Page

The first page of the manuscript should be a title page with the following:

* Title

The title of the manuscript in sentence case. No abbreviations other than gene names or in common use.

* Full names, email address and affiliations including postal codes of all authors

Authors affiliations should reflect where their primary contribution to the research was made. Affiliations of the authors indicated by numbers (not symbols), Equal contribution indicated by †.

* Corresponding author and corresponding email address

Clearly indicate who will handle correspondence at all stages of refereeing and publication, also post-publication. This responsibility includes answering any future queries about Methodology and Materials. SV allows up to two corresponding authors; when two are listed, no priority is given to either. The submitting author is required a corresponding author. Please provided the corresponding author Name, full postal address, including street number and name, and institutional email address.

* Conflict of interest statement

This section is required for all papers. If there are no interests to declare, please use the following wording: "The authors declare no competing interests." The text in this section should match the text provided in the Declaration of Interests form.

* Acknowledgments

Use this section to acknowledge contributions from non-authors, list funding sources. As this section contains important information and many funding bodies require inclusion of grant numbers here, please check it carefully.


Abstract (300 words maximum)

A concise and factual abstract is required. The abstract should state briefly the purpose of the research, the principal results and major conclusions. No methodological information. This section should no more than 300 words, be continuous and without reference numbers. No abbreviations in Abstract, unless they correspond to a gene name. Abbreviations that appear once only, should be defined in full, unless they correspond to a gene name. If abbreviations appear more than once, the definition should be provided once, and then subsequently used throughout the abstract.


Immediately after the abstract, provide 3-10 keywords, using avoiding general and plural terms and multiple concepts (avoid, for example, 'and', 'of').


State the objectives of the work and provide an adequate background to clarify why the study was undertaken and what hypotheses were tested, avoiding a detailed literature survey or a summary of the results. The information in this section should always be referenced and must discuss the literature.

Materials and Methods

The source of material used and relevant ethical framework for all experiments should be clearly identified (ethics approval and/or written informed consent).


Methods already published should be indicated by a reference: only relevant modifications should be described. This implies that a full description of all the experiments described in Results and presented in the Figures/Tables is expected in this section. For each experiment, all steps need to be mentioned, along with instruments the analyses were performed on, reagents and methods to permit the replication of the work by others. we would encourage authors to submitting a detailed Bio-protocol.


Explain how these were collected, handled and stored, and where they were from.

Bacterial, strains or cells

Provide the name and supplier. Matching between controls and disease patients with regards to the above parameters.

Steps performed with commercialized kits

Provide the full name of the kit, along with the full name and location (city, province or state, and country) of the supplier, and state whether the protocol of the manufacturer was followed or explain any modifications made to the standard protocol.

Bioinformatics analyses

State the software used along with the relevant citation, unless the software is not published, in which case a website link can be provided. For microarray/RNA sequences, data downloaded from GEO or other databases, this needs to be clarified in the text, along with the corresponding accession number of the dataset.

Statistical analyses

When statistical analyses have been performed, the following information should be provided: the name of the statistical test used, the number for each analysis, the comparisons of interest, the alpha level and the actual p-value for each test. It should be clear which statistical test was used to generate every p-value. Error bars on graphs should be clearly labeled, and it should be stated whether the number following the ± sign is a standard deviation or a standard error. The word ‘significant’ should only be used when referring to statistically significant results and should be accompanied by the relevant p-value. Significance indicators should be used on graphs and tables, and should be described in the figure or table legend, clearly indicating which groups are being compared. Describe any statistical software used to perform analyses.


Include a concise summary of the data presented in all display items (figures and tables). Excessive elaboration of data shown in display items should be avoided. Numerical data should be analyzed using appropriate statistical tests described in the Experimental Design and Statistical Analysis section. Authors must provide detailed information for each statistical test applied. If some references are needed to support the results they can be inserted in the Discussion section.


This should explore the significance of the results of the work, not repeat them. A combined Results and Discussion section is often appropriate. Avoid extensive citations and discussion of published literature.


The main conclusions of the study may be presented in a short Conclusions section, which may stand alone or form a subsection of a Discussion or Results and Discussion section.

Back matter

Ethics approval and consent to participate

Manuscripts reporting studies involving human participants, human data or human tissue must: include a statement on ethics approval and consent (even where the need for approval was waived) include the name of the ethics committee that approved the study and the committee’s reference number if appropriate. Studies involving animals must include a statement on ethics approval. More information about editorial policies.

Authors’ Contributions

These should be presented as follows: GF, LH and PG designed the research study. LH performed the research. MM provided help and advice on the ELISA experiments. MH analyzed the data. LL, LC and PG wrote the manuscript. All authors contributed to editorial changes in the manuscript. All authors read and approved the final manuscript.


References list sort numerically. The reference list should be limited to only those citations essential to the presentation. Before submission of the manuscript, authors should verify the accuracy of all references and check that all references have been cited in the text. Please list all authors’ names if the authors less than 6. For the authors more than 6, use “et al”. Please list the abbreviative name of the journal. The reference should include all the pages.

Reference examples:

Use the [number] for the references in the text.

(1) Journal:

① Single Author

[1] Boyden EA. A critique of the international nomenclature on bronchopulmonary segments. Diseases of the chest. 1953;23:266-269.

② Two Authors

[2] McNarry AF, Goldhill DR. Simple bedside assessment of level of consciousness: comparison of two simple assessment scales with the Glasgow Coma scale. Anaesthsia. 2004;59:34–37

③ More than 6 authors

[3] Churpek MM, Yuen TC, Park SY, McNarry AF, Goldhill DR, Boyden EA, et al. Derivation of a cardiac arrest prediction model using ward vital signs. Crit Care Med. 2012;40:2102–2108.

(2) Book:

[1] Kolacek S, Mestrovic J. Vascular access, including complications. In: Langnas AN, Goulet O, Quigley EMM, Tappenden KA, editors. Intestinal failure, 1st ed. Malden, MA: Blackwell Publishing; 2008. p. 142-150.

[2] Lang TA, Secic M. How to report statistics in medicine. Philadelphia: American College of Physicians; 1997.

(3) Patent:

[1] Anninos, P. A., Tsagas, N. (1995) Electronic apparatus for treating epileptic epileptic individuals. USA patent NO. 5453072.

(4) If there are non-English journals in the reference, please insert the journal language as the ending. For example:

[1] Wiese, L., Kurtzhals, J. A., Penkowa, M. (2006) Neuronal apoptosis metallothionein expression. German Neurology 200, 216-226. (In German)

(5) website:

[1] Ricou B, Bandschap O. Propofol and perioperative inflammation. ClinicalTrials.gov 2010. accessable on: https://clinicaltrials.gov/ct2/show/NCT01115179.

Figure Legends

Legends should be included in the submitted manuscript as a separate section. Each figure legend should have a brief title that describes the entire figure without citing specific panels, followed by a detailed description of each panel. It is not acceptable to give only one or two lines figure legends. In writing the figure title, we encourage you to re-use the subheadings of the Results section to make the relationship clear. For any figures presenting pooled data, the measures should be defined in the figure legends (for example, "Data are represented as mean ± SEM."). Each legend should refer to any supporting items in the Supplemental Information (e.g., "See also Figure S1.").

Supplementary materials

Authors of accepted manuscripts may provide related supplemental data to be posted online along with the published manuscript. This may include figures, tables, or appendices but excludes large datasets. All Supplemental Data information (except videos) should be combined into a single PDF file. Before submission, carefully review all files; if you wish to make changes to supplementary material during any stage of the process, please make sure to provide an updated file. The journal is not responsible for any errors contained in data supplements.

Sharing and promoting your article

Now that your article is published, you can promote it to make a bigger impact with your research.

Sharing research, accomplishments, and ambitions with a wider audience makes you more visible in your field. This helps you get cited more, enabling you to cultivate a stronger reputation, promote your research and move forward in your career.

As your publisher, we are committed to ensuring your research makes an impact by reaching as wide and diverse an audience as possible. Working in partnership with you means we can achieve an even greater impact.

Sharing research is an important part of the research process. This simple guide will help you share your research broadly.

1. Get an electronic version of the link

You can get an electronic version of the link that you can share with all your colleagues or friends who can read your work for free. You can share this electronic link to any platform you like.

Click on the electronic version of the link, the reader can directly open the article published on SV. In this way, every download (and cite) will be recorded, making the impact of your work at a glance.

2. Add to your reading lists

Get your students reading and talking about your article. Add it, or the journal it’s included in, to your course’s essential reading list.

3. Update web pages

Lots of people browsing your institutional and departmental websites? Use this to your advantage by adding a link on your departmental profile page, directing people to your latest article.

4. Use social media

Various social platforms are increasingly popular tools amongst researchers, such as Weibo ResearchGate, Twitter, Facebook or Linkedin. They’re a quick and easy way for researchers to talk about developments in their research field or post about their latest publication. If people start talking about your article, it can increase awareness and readers enormously. It’s also a great way to reach media outlets, with the potential for journalists to pick up on newsworthy research.

5. Update your profile on professional and academic networking sites

If you’re on Linkedin, Academia.edu, ResearchGate, Mendeley, or any other professional or academic networking site, you can include links to your article, building a complete picture of your professional expertise and accomplishments. People looking at your profile are already interested in you, and highly likely to click through and read your research.

6. Post to discussion lists

It’s easy to post a short message to any discussion lists you are a member of, letting people know that the journal’s latest issue, which includes your article, is now available. You can register for the Table of Contents alert for the journal, and forward on the email as soon as it comes through.

7. Tell people on your blog

If you blog, don’t forget to tell your readers about your latest article.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.3 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

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