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Special Issue Title:

Advances in the Diagnosis and Management of Sepsis and Septic Shock

Deadline for manuscript submissions: 01 May 2026

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Special Issue Editor

  • Guest Editor

    Prof. Dr. Ozgur Karcioglu, MDE-MailWebsite

    Emergency Physician, Department of Emergency Medicine, University of Health Sciences, Istanbul Training and Research Hospital, Fatih, Istanbul, Türkiye

    Interests: Emergency Medicine; Resuscitation; Cardiac Care; Acute Disease; Diagnosis; Trauma; Emergency Management

  • Guest Editor

    Assoc. Prof. Dr. Feride Sinem AKGUN, MDE-MailWebsite

    Emergency Physician, Department of Emergency Medicine, Istanbul Maltepe University, Maltepe, Istanbul, Türkiye

    Interests: Emergency Medicine

  • Guest Editor

    Assist. Prof. Dr. Betul AKBUGA OZEL, MDE-MailWebsite

    Emergency Physician, Department of Emergency Medicine, Yıldırım Beyazıt University, Faculty of Medicine, Ankara Bilkent City Hospital, Ankara, Türkiye

    Interests: Emergency Medicine

Special Issue Information

Sepsis is recognized with dysregulated host response to infection triggering life-threatening organ dysfunction, which composes a high risk for grave outcomes. Severe sepsis is suspected in a significant ratio of patients presenting with an infection in the emergency departments (ED). Sepsis is a great burden on society, especially affecting the elderly, neonates and other vulnerable groups. Septic shock is defined by clinical findings of systemic tissue hypoperfusion, including supranormal lactate levels, with or without arterial hypotension. Administration of vasopressors in the management of septic shock is critical to achieve survival.


Recognition of sepsis in children and the elderly in the ED can be difficult due to the high prevalence of mimicking conditions, the lack of specific diagnostic features, and the involved patients’ capacity to compensate until the advanced stages of shock. Scoring systems such as Modified Early Warning Score (MEWS) and National Early Warning Score (NEWS) demonstrated higher predictive values for admission to ICU and death than qSOFA. The QSOFA score may help to achieve faster recognition of sepsis in the ED for timely management. 


Sepsis requires multidisciplinary and multi-faceted management. It is one of the clinical situations in which timing is most critical. Emergency healthcare workers are pioneers in evaluating and intervening with patients for life-threatening conditions, including sepsis, within the context of the modern healthcare system. This special issue “Advances in the diagnosis and management of sepsis and septic shock” is designed to cover up-to-date research topics in the field of diagnosis and treatment of sepsis and septic shock, their complications, outcomes, and relevant management recommendations.

Keywords

Diagnosis; Management; Sepsis; Septic Shock; Lactate Hypotension; Vasopressors

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Signa Viate is an international peer-reviewed open access journal published by MRE Press. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1500. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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