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Special Issue Title:

Postreperfusion Cardiac Arrest (PRCA) in the Era of Liver Transplantation From Extended Criteria Donor Liver Grafts

Deadline for manuscript submissions: 31 December 2021

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Special Issue Editor

  • Guest Editor

    Dr. Ming TianE-MailWebsite

    Professor of Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, NO. 95 Yong-An Road, Xi-Cheng District, Beijing100050, Beijing, China

    Interests: Postreperfusion syndrome during liver transplantation, Difficult airway management, Anesthesia for gastrointestinal endoscopy, Quality control and assurance in anesthesia

Special Issue Information

Liver transplantation (LT) is generally considered to be the non-cardiac surgery with the highest risk of intraoperative cardiac arrest (ICA). Noteworthily, ICA is most often observed during the reperfusion period and is specifically named as postreperfusion cardiac arrest (PRCA). PRCA is a rare but catastrophic intraoperative cardiovascular complication associated with high perioperative mortality. Indeed, the etiology of PRCA is multifactorial, including recipient, donor, surgical, and anesthesia-related causes. Nonetheless, donor-related factors have captured increasing attention in response to the increased worldwide utilization of expanded criteria donor (ECD) liver grafts, especially donation after circulatory death (DCD) and macrosteatotic liver grafts. Numerous studies have revealed that there is a close relationship between the use of ECD liver grafts and the occurrence of postreperfusion hyperkalemia, postreprfusion syndrome (PRS), and PRCA. However, the exact mechanism of postreperfusion hyperkalemia and PRCA induced by ECD liver grafts has not been fully elucidated. Most importantly, there remains a paucity of effective strategy for the prevention and treatment of PRCA during LT from ECD liver grafts. In the era of ECD, more studies are warranted to clarify the etiologies, preventions, and treatments of postreperfusion hyperkalemia and PRCA.

This special issue is designed to collect and publish research of PRCA in the era of LT from ECD liver grafts, especially focusing on prevention and therapy to reduce the incidence of PRCA induced by ECD liver grafts. We accept original clinical and fundamental research articles, case reports, or comprehensive reviews. The goal of this special issue is to help liver transplant surgeons and anesthesiologists learn new advances of prediction, prevention, treatment of PRCA during LT from ECD liver grafts. 


Intraoperative cardiac arrest (ICA), Postreperfusion cardiac arrest (PRCA), Liver transplantation (LT), Expanded criteria donor (ECD), Marginal donor, Postreperfusion syndrome (PRS), Hyperkalemia

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Signa Viate is an international peer-reviewed open access journal published by MRE Press. As of January 2021, Signa Vitae will change to a bimonthly journal. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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